KEGG   REACTION: R07603
Entry
R07603                      Reaction                               
Definition
(S)-3-Methyl-2-oxopentanoic acid + Thiamin diphosphate <=> 2-Methyl-1-hydroxybutyl-ThPP + CO2
Equation
C00671 + C00068 <=> C15978 + C00011
Comment
Oxo-acid dehydrogenase complexes (see R04225), subsequently R07604
Reaction class
RC00027  C00068_C15978
RC02949  C00671_C15978
Enzyme
1.2.4.4
Pathway
rn00280  Valine, leucine and isoleucine degradation
rn00785  Lipoic acid metabolism
Brite
Enzymatic reactions [BR:br08201]
 1. Oxidoreductase reactions
  1.2  Acting on the aldehyde or oxo group of donors
   1.2.4  With a disulfide as acceptor
    1.2.4.4
     R07603  (S)-3-Methyl-2-oxopentanoic acid + Thiamin diphosphate <=> 2-Methyl-1-hydroxybutyl-ThPP + CO2
Orthology
K00166  2-oxoisovalerate dehydrogenase E1 component subunit alpha [EC:1.2.4.4]
K00167  2-oxoisovalerate dehydrogenase E1 component subunit beta [EC:1.2.4.4]
K11381  2-oxoisovalerate dehydrogenase E1 component [EC:1.2.4.4]
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