KEGG   REACTION: R03947
Entry
R03947                      Reaction                               
Name
S-adenosyl-L-methionine:uroporphyrin-III C-methyltransferase
Definition
Precorrin 2 + NAD+ <=> Sirohydrochlorin + NADH + H+
Equation
C02463 + C00003 <=> C05778 + C00004 + C00080
Comment
multifunctional enzyme: siroheme synthase: precorrin-2 dehydrogenase (R03194+R03947+R02864)
following after R03194, subsequently R02864
Reaction class
RC00001  C00003_C00004
RC01034  C02463_C05778
Enzyme
1.3.1.76
Pathway
rn00860  Porphyrin metabolism
rn01100  Metabolic pathways
rn01110  Biosynthesis of secondary metabolites
rn01120  Microbial metabolism in diverse environments
rn01240  Biosynthesis of cofactors
Module
M00846  Siroheme biosynthesis, glutamyl-tRNA => siroheme
M00924  Cobalamin biosynthesis, anaerobic, uroporphyrinogen III => sirohydrochlorin => cobyrinate a,c-diamide
Brite
Enzymatic reactions [BR:br08201]
 1. Oxidoreductase reactions
  1.3  Acting on the CH-CH group of donors
   1.3.1  With NAD+ or NADP+ as acceptor
    1.3.1.76
     R03947  Precorrin 2 + NAD+ <=> Sirohydrochlorin + NADH + H+
Orthology
K02302  uroporphyrin-III C-methyltransferase / precorrin-2 dehydrogenase / sirohydrochlorin ferrochelatase [EC:2.1.1.107 1.3.1.76 4.99.1.4]
K02304  precorrin-2 dehydrogenase / sirohydrochlorin ferrochelatase [EC:1.3.1.76 4.99.1.4]
K24866  precorrin-2 dehydrogenase [EC:1.3.1.76]
Other DBs
RHEA: 15616
LinkDB

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