KEGG   NETWORK: N00284
Entry
N00284                      Network                                
Name
AREG-EGFR-PI3K signaling pathway
Definition
AREG -> EGFR -> PI3K -> PIP3 -> AKT -> MTOR -> S6K
  Expanded
374 -> 1956 -> (5290,5291,5293) -> C05981 -> (207,208,10000) -> 2475 -> (6198,6199)
Class
nt06260 Colorectal cancer
nt06261 Gastric cancer
nt06262 Pancreatic cancer
nt06214 PI3K signaling (cancer)
Type
Reference
Pathway
hsa04151  PI3K-Akt signaling pathway
Gene
374  AREG; amphiregulin
1956  EGFR; epidermal growth factor receptor
5290  PIK3CA; phosphatidylinositol-4,5-bisphosphate 3-kinase catalytic subunit alpha
5291  PIK3CB; phosphatidylinositol-4,5-bisphosphate 3-kinase catalytic subunit beta
5293  PIK3CD; phosphatidylinositol-4,5-bisphosphate 3-kinase catalytic subunit delta
207  AKT1; AKT serine/threonine kinase 1
208  AKT2; AKT serine/threonine kinase 2
10000  AKT3; AKT serine/threonine kinase 3
2475  MTOR; mechanistic target of rapamycin kinase
6198  RPS6KB1; ribosomal protein S6 kinase B1
6199  RPS6KB2; ribosomal protein S6 kinase B2
Metabolite
C05981  Phosphatidylinositol-3,4,5-trisphosphate
Reference
PMID:14967450
  Authors
Marmor MD, Skaria KB, Yarden Y.
  Title
Signal transduction and oncogenesis by ErbB/HER receptors.
  Journal
Int J Radiat Oncol Biol Phys 58:903-13 (2004)
DOI:10.1016/j.ijrobp.2003.06.002
Reference
PMID:17000658
  Authors
Scaltriti M, Baselga J.
  Title
The epidermal growth factor receptor pathway: a model for targeted therapy.
  Journal
Clin Cancer Res 12:5268-72 (2006)
DOI:10.1158/1078-0432.CCR-05-1554
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