KEGG   NETWORK: N00011
Entry
N00011                      Network                                
Name
Mutation-activated FGFR3 to RAS-ERK signaling pathway
Definition
FGFR3* -> GRB2 -> SOS -> RAS -> RAF -> MEK -> ERK -> MSK1 -> MYC
  Expanded
(2261v1,2261v2) -> 2885 -> (6654,6655) -> (3265,3845,4893) -> (369,673,5894) -> (5604,5605) -> (5594,5595) -> 9252 -> 4609
Class
nt06265 Bladder cancer
nt06210 ERK signaling (cancer)
Type
Variant
Pathway
hsa05219  Bladder cancer
Disease
H00022  Bladder cancer
Gene
2261  FGFR3; fibroblast growth factor receptor 3
2885  GRB2; growth factor receptor bound protein 2
6654  SOS1; SOS Ras/Rac guanine nucleotide exchange factor 1
6655  SOS2; SOS Ras/Rho guanine nucleotide exchange factor 2
3265  HRAS; HRas proto-oncogene, GTPase
3845  KRAS; KRAS proto-oncogene, GTPase
4893  NRAS; NRAS proto-oncogene, GTPase
369  ARAF; A-Raf proto-oncogene, serine/threonine kinase
673  BRAF; B-Raf proto-oncogene, serine/threonine kinase
5894  RAF1; Raf-1 proto-oncogene, serine/threonine kinase
5604  MAP2K1; mitogen-activated protein kinase kinase 1
5605  MAP2K2; mitogen-activated protein kinase kinase 2
5594  MAPK1; mitogen-activated protein kinase 1
5595  MAPK3; mitogen-activated protein kinase 3
9252  RPS6KA5; ribosomal protein S6 kinase A5
4609  MYC; MYC proto-oncogene, bHLH transcription factor
Variant
2261v1 (FGFR3*)  FGFR3 mutation
2261v2 (FGFR3*)  FGFR3 erdafitinib-susceptible variation
Reference
PMID:16110317
  Authors
Wu XR.
  Title
Urothelial tumorigenesis: a tale of divergent pathways.
  Journal
Nat Rev Cancer 5:713-25 (2005)
DOI:10.1038/nrc1697
Reference
PMID:17149381
  Authors
Sugano K, Kakizoe T.
  Title
Genetic alterations in bladder cancer and their clinical applications in molecular tumor staging.
  Journal
Nat Clin Pract Urol 3:642-52 (2006)
DOI:10.1038/ncpuro0649
Reference
PMID:16474624
  Authors
Wolff EM, Liang G, Jones PA.
  Title
Mechanisms of Disease: genetic and epigenetic alterations that drive bladder cancer.
  Journal
Nat Clin Pract Urol 2:502-10 (2005)
DOI:10.1038/ncpuro0318
Reference
PMID:26003532
  Authors
Gallo LH, Nelson KN, Meyer AN, Donoghue DJ
  Title
Functions of Fibroblast Growth Factor Receptors in cancer defined by novel translocations and mutations.
  Journal
Cytokine Growth Factor Rev 26:425-49 (2015)
DOI:10.1016/j.cytogfr.2015.03.003
Reference
PMID:25589496
  Authors
Nakanishi Y, Akiyama N, Tsukaguchi T, Fujii T, Satoh Y, Ishii N, Aoki M
  Title
Mechanism of Oncogenic Signal Activation by the Novel Fusion Kinase FGFR3-BAIAP2L1.
  Journal
Mol Cancer Ther 14:704-12 (2015)
DOI:10.1158/1535-7163.MCT-14-0927-T
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