KEGG   ORTHOLOGY: K18316
Entry
K18316                      KO                                     
Symbol
cpmA, carA
Name
carbapenam-3-carboxylate synthase [EC:6.3.3.6]
Pathway
map00332  Carbapenem biosynthesis
map01100  Metabolic pathways
map01110  Biosynthesis of secondary metabolites
map02024  Quorum sensing
Module
M00675  Carbapenem-3-carboxylate biosynthesis, pyrroline-5-carboxylate + malonyl-CoA => carbapenem-3-carboxylate
Reaction
R10556  (2S,5S)-5-carboxymethylproline cyclo-ligase (AMP-forming)
Brite
KEGG Orthology (KO) [BR:ko00001]
 09100 Metabolism
  09110 Biosynthesis of other secondary metabolites
   00332 Carbapenem biosynthesis
    K18316  cpmA, carA; carbapenam-3-carboxylate synthase
 09140 Cellular Processes
  09145 Cellular community - prokaryotes
   02024 Quorum sensing
    K18316  cpmA, carA; carbapenam-3-carboxylate synthase
Enzymes [BR:ko01000]
 6. Ligases
  6.3  Forming carbon-nitrogen bonds
   6.3.3  Cyclo-ligases
    6.3.3.6  carbapenam-3-carboxylate synthase
     K18316  cpmA, carA; carbapenam-3-carboxylate synthase
Other DBs
COG: COG0367
Genes
SERA: Ser39006_009920
SERQ: CWC46_09915
PROD: PCO85_15490
PARI: I2D83_01750
PPAV: LOZ86_02760
PCAC: OI450_17095
PACB: M9782_00175
DZE: Dd1591_0213
DAQ: DAQ1742_04174(cpmA)
PAO: Pat9b_5317
PLU: plu0182(cpmA)
PLUM: A4R40_00880
PTT: VY86_09615
PRG: RB151_027380(carA_2)
VSR: Vspart_02935(bls)
VRU: RND59_08420
BGP: BGL_2c27620
BPLA: bpln_2g27660
BURT: BTHE68_05020
AG: AAD38229(carA)
 » show all
Reference
PMID:19371088
  Authors
Raber ML, Arnett SO, Townsend CA
  Title
A conserved tyrosyl-glutamyl catalytic dyad in evolutionarily linked enzymes: carbapenam synthetase and beta-lactam synthetase.
  Journal
Biochemistry 48:4959-71 (2009)
DOI:10.1021/bi900432n
  Sequence
[ag:AAD38229]
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