KEGG   ORTHOLOGY: K18091
Entry
K18091                      KO                                     
Symbol
pntE, penE, ptlE
Name
pentalenolactone D synthase [EC:1.14.13.170 1.14.13.171]
Pathway
map00998  Biosynthesis of various antibiotics
map01100  Metabolic pathways
map01110  Biosynthesis of secondary metabolites
Module
M00819  Pentalenolactone biosynthesis, farnesyl-PP => pentalenolactone
Reaction
R10154  1-deoxy-11-oxopentalenate,NADH:oxygen oxidoreductase (pentalenolactone-D forming)
R10155  1-deoxy-11-oxopentalenate,NADH:oxygen oxidoreductase (neopentalenolactone-D forming)
Brite
KEGG Orthology (KO) [BR:ko00001]
 09100 Metabolism
  09110 Biosynthesis of other secondary metabolites
   00998 Biosynthesis of various antibiotics
    K18091  pntE, penE, ptlE; pentalenolactone D synthase
Enzymes [BR:ko01000]
 1. Oxidoreductases
  1.14  Acting on paired donors, with incorporation or reduction of molecular oxygen
   1.14.13  With NADH or NADPH as one donor, and incorporation of one atom of oxygen into the other donor
    1.14.13.170  pentalenolactone D synthase
     K18091  pntE, penE, ptlE; pentalenolactone D synthase
    1.14.13.171  neopentalenolactone D synthase
     K18091  pntE, penE, ptlE; pentalenolactone D synthase
Other DBs
COG: COG2072
Genes
MHOL: K3U96_25175
MHER: K3U94_10700
SMA: SAVERM_2994(ptlE)
SBH: SBI_09676
SCI: B446_29680
SCW: TU94_27390
SLE: sle_13190(sle_13190)
SSIA: A7J05_09255
SGJ: IAG43_27140
SHK: J2N69_35820
AG: ADO85575(pntE) ADO85591(penE)
 » show all
Reference
PMID:21250661
  Authors
Seo MJ, Zhu D, Endo S, Ikeda H, Cane DE
  Title
Genome mining in Streptomyces. Elucidation of the role of Baeyer-Villiger monooxygenases and non-heme iron-dependent dehydrogenase/oxygenases in the final steps of the biosynthesis of pentalenolactone and neopentalenolactone.
  Journal
Biochemistry 50:1739-54 (2011)
DOI:10.1021/bi1019786
  Sequence
[sma:SAVERM_2994] [ag:ADO85591 ADO85575]
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