Entry Symbol tcmI
Name Pathway map01057 Biosynthesis of type II polyketide products
map01110 Biosynthesis of secondary metabolites
Module M00783 Tetracenomycin C/8-demethyltetracenomycin C biosynthesis, tetracenomycin F2 => tetracenomycin C/8-demethyltetracenomycin C
Reaction R06699 tetracenomycin-F2 hydro-lyase (tetracenomycin-F1-forming)
Brite KEGG Orthology (KO) [BR:ko00001 ]ko01000 ]ko01008 ] BRITE hierarchy Genes Taxonomy UniProt Reference Authors Thompson TB, Katayama K, Watanabe K, Hutchinson CR, Rayment I
Title Structural and functional analysis of tetracenomycin F2 cyclase from Streptomyces glaucescens. A type II polyketide cyclase.
Journal Reference Authors Shen B, Hutchinson CR
Title Tetracenomycin F2 cyclase: intramolecular aldol condensation in the biosynthesis of tetracenomycin C in Streptomyces glaucescens.
Journal Sequence Reference Authors Summers RG, Wendt-Pienkowski E, Motamedi H, Hutchinson CR
Title The tcmVI region of the tetracenomycin C biosynthetic gene cluster of Streptomyces glaucescens encodes the tetracenomycin F1 monooxygenase, tetracenomycin F2 cyclase, and, most likely, a second cyclase.
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