KEGG ORTHOLOGY: K15941

ORTHOLOGY: K15941

Entry

K15941                      KO

Symbol

snoaB, dnrG, aknX

Name

deoxynogalonate / 12-deoxyaklanonic acid monooxygenase [EC:1.13.12.22 1.13.12.-]

Pathway

map01057

Biosynthesis of type II polyketide products

map01100

Metabolic pathways

map01110

Biosynthesis of secondary metabolites

Module

M00781

Nogalavinone/aklavinone biosynthesis, deoxynogalonate/deoxyaklanonate => nogalavinone/aklavinone

Reaction

R06679

12-deoxyaklanonic-acid:oxygen oxidoreductase

R09327

deoxynogalonate:oxygen oxidoreductase

Brite

KEGG Orthology (KO) [BR:ko00001]
09100 Metabolism
  09109 Metabolism of terpenoids and polyketides
   01057 Biosynthesis of type II polyketide products
    K15941  snoaB, dnrG, aknX; deoxynogalonate / 12-deoxyaklanonic acid monooxygenase
09180 Brite Hierarchies
  09181 Protein families: metabolism
   01008 Polyketide biosynthesis proteins
    K15941  snoaB, dnrG, aknX; deoxynogalonate / 12-deoxyaklanonic acid monooxygenase
Enzymes [BR:ko01000]
1. Oxidoreductases
  1.13  Acting on single donors with incorporation of molecular oxygen (oxygenases)
   1.13.12  With incorporation of one atom of oxygen (internal monooxygenases or internal mixed-function oxidases)
    1.13.12.22  deoxynogalonate monooxygenase
     K15941  snoaB, dnrG, aknX; deoxynogalonate / 12-deoxyaklanonic acid monooxygenase
Polyketide biosynthesis proteins [BR:ko01008]
Polyketide tailoring proteins
  Oxygenase
   K15941  snoaB, dnrG, aknX; deoxynogalonate / 12-deoxyaklanonic acid monooxygenase

Genes

SPRI:

SPRI_0238

SRW:	TUE45_01321

STIR:

SGAL:

SCIN:

STSU:

SCOE:

SLIA:

SPEU:

SXN:	IAG42_36735

SDD:	D9753_08545

SNIG:

HEK616_47560

SJN:	RI060_18285

SHAU:

K9S39_40670

SKG:	KJK29_16080

SINN:

STPB:

TCU:

PMAD:

MAU:	Micau_3995

MIL:

ML5_4426

MFEU:

H1D33_25705

AG:	AAA65205(dnrG) AAF70105(aknX) CAA12015(snoaB)

» show all

Reference

PMID:8668120

Authors

Ylihonko K, Tuikkanen J, Jussila S, Cong L, Mantsala P

Title

A gene cluster involved in nogalamycin biosynthesis from Streptomyces nogalater: sequence analysis and complementation of early-block mutations in the anthracycline pathway.

Journal

Mol Gen Genet 251:113-20 (1996)
DOI:10.1007/BF02172908

Sequence

[ag:CAA12015]

Reference

PMID:20052967

Authors

Grocholski T, Koskiniemi H, Lindqvist Y, Mantsala P, Niemi J, Schneider G

Title

Crystal structure of the cofactor-independent monooxygenase SnoaB from Streptomyces nogalater: implications for the reaction mechanism.

Journal

Biochemistry 49:934-44 (2010)
DOI:10.1021/bi901985b