KEGG   ORTHOLOGY: K12745
Entry
K12745                      KO                                     
Symbol
cefF
Name
deacetoxycephalosporin-C hydroxylase [EC:1.14.11.26]
Pathway
map00311  Penicillin and cephalosporin biosynthesis
map01100  Metabolic pathways
map01110  Biosynthesis of secondary metabolites
Module
M00673  Cephamycin C biosynthesis, aminoadipate + cycteine + valine => cephamycin C
Reaction
R05229  
Brite
KEGG Orthology (KO) [BR:ko00001]
 09100 Metabolism
  09110 Biosynthesis of other secondary metabolites
   00311 Penicillin and cephalosporin biosynthesis
    K12745  cefF; deacetoxycephalosporin-C hydroxylase
 09180 Brite Hierarchies
  09181 Protein families: metabolism
   01008 Polyketide biosynthesis proteins
    K12745  cefF; deacetoxycephalosporin-C hydroxylase
Enzymes [BR:ko01000]
 1. Oxidoreductases
  1.14  Acting on paired donors, with incorporation or reduction of molecular oxygen
   1.14.11  With 2-oxoglutarate as one donor, and incorporation of one atom of oxygen into each donor
    1.14.11.26  deacetoxycephalosporin-C hydroxylase
     K12745  cefF; deacetoxycephalosporin-C hydroxylase
Polyketide biosynthesis proteins [BR:ko01008]
 Nonribosomal peptide tailoring proteins
  Others
   K12745  cefF; deacetoxycephalosporin-C hydroxylase
Other DBs
GO: 0045442
Genes
XRY: QN244_11755
SCLF: BB341_07760
SCT: SCAT_5681(cefF)
SCY: SCATT_56810
AAB: A4R43_03240
AMYY: YIM_39165(cefF)
PSUU: Psuf_059670
AG: AAA26716(cefF) CAA79803(cefF)
Reference
PMID:2002049
  Authors
Baker BJ, Dotzlaf JE, Yeh WK
  Title
Deacetoxycephalosporin C hydroxylase of Streptomyces clavuligerus. Purification, characterization, bifunctionality, and evolutionary implication.
  Journal
J Biol Chem 266:5087-93 (1991)
  Sequence
[ag:AAA26716]
Reference
PMID:8703431
  Authors
Coque JJ, Enguita FJ, Cardoza RE, Martin JF, Liras P
  Title
Characterization of the cefF gene of Nocardia lactamdurans encoding a 3'-methylcephem hydroxylase different from the 7-cephem hydroxylase.
  Journal
Appl Microbiol Biotechnol 44:605-9 (1996)
DOI:10.1007/BF00172492
  Sequence
[ag:CAA79803]
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