KEGG   ORTHOLOGY: K12696
Entry
K12696            Tight     KO                                     
Symbol
CYP71D12
Name
tabersonine 16-hydroxylase [EC:1.14.14.103]
Pathway
map00901  Indole alkaloid biosynthesis
map01100  Metabolic pathways
map01110  Biosynthesis of secondary metabolites
Module
M00965  Vinblastine biosynthesis, geissoschizine => vinblastine
Reaction
R05855  tabersonine,[reduced NADPH---hemoprotein reductase]:oxygen oxidoreductase (16-hydroxylating)
Brite
KEGG Orthology (KO) [BR:ko00001]
 09100 Metabolism
  09110 Biosynthesis of other secondary metabolites
   00901 Indole alkaloid biosynthesis
    K12696  CYP71D12; tabersonine 16-hydroxylase
 09180 Brite Hierarchies
  09181 Protein families: metabolism
   00199 Cytochrome P450
    K12696  CYP71D12; tabersonine 16-hydroxylase
Enzymes [BR:ko01000]
 1. Oxidoreductases
  1.14  Acting on paired donors, with incorporation or reduction of molecular oxygen
   1.14.14  With reduced flavin or flavoprotein as one donor, and incorporation of one atom of oxygen into the other donor
    1.14.14.103  tabersonine 16-hydroxylase
     K12696  CYP71D12; tabersonine 16-hydroxylase
Cytochrome P450 [BR:ko00199]
 Cytochrome P450, plant type
  CYP71 family
   K12696  CYP71D12; tabersonine 16-hydroxylase
Other DBs
GO: 0050594
Genes
AG: CAB56503(CYP71D12)
Reference
PMID:12228585
  Authors
St-Pierre B, De Luca V.
  Title
A Cytochrome P-450 Monooxygenase Catalyzes the First Step in the Conversion of Tabersonine to Vindoline in Catharanthus roseus.
  Journal
Plant Physiol 109:131-139 (1995)
DOI:10.1104/pp.109.1.131
Reference
PMID:10481044
  Authors
Schroder G, Unterbusch E, Kaltenbach M, Schmidt J, Strack D, De Luca V, Schroder J.
  Title
Light-induced cytochrome P450-dependent enzyme in indole alkaloid biosynthesis: tabersonine 16-hydroxylase.
  Journal
FEBS Lett 458:97-102 (1999)
DOI:10.1016/S0014-5793(99)01138-2
  Sequence
[ag:CAB56503]
LinkDB

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