KEGG ORTHOLOGY: K01663

ORTHOLOGY: K01663

Entry

K01663                      KO

Symbol

HIS7

Name

imidazole glycerol-phosphate synthase [EC:4.3.2.10]

Pathway

map00340

Histidine metabolism

map01100

Metabolic pathways

map01110

Biosynthesis of secondary metabolites

map01230

Biosynthesis of amino acids

Module

M00026

Histidine biosynthesis, PRPP => histidine

Reaction

R04558

5-[(5-phospho-1-deoxy-D-ribulos-1-ylamino)methylideneamino]-1-(5-phospho-beta-D-ribosyl)imidazole-4-carboxamide D-erythro-1-(imidazol-4-yl)glycerol 3-phosphate-lyase (L-glutamine-hydrolysing; 5-amino-1-(5-phospho-beta-D-ribosyl)imidazole-4-carboxamide-forming)

Brite

KEGG Orthology (KO) [BR:ko00001]
09100 Metabolism
  09105 Amino acid metabolism
   00340 Histidine metabolism
    K01663  HIS7; imidazole glycerol-phosphate synthase
Enzymes [BR:ko01000]
4. Lyases
  4.3  Carbon-nitrogen lyases
   4.3.2  Amidine-lyases
    4.3.2.10  imidazole glycerol-phosphate synthase
     K01663  HIS7; imidazole glycerol-phosphate synthase

Other DBs

COG:	COG0118 COG0107

GO:

0000107

Genes

NVE:

5505657

PDAM:

113668256

SPIS:

111325806

ATH:	AT4G26900(AT-HF)

ALY:

9303608

CRB:

17881013

CSAT:

104717543 104722242 104730701

EUS:	EUTSA_v10024744mg

BRP:	103863841 103866702

BNA:	106426580 106445482 106445959

BOE:	106294789 106337126

RSZ:

THJ:

CPAP:

CIT:

CIC:	CICLE_v10007818mg

PVY:

116143242

MINC:

123193965 123201884 123207492

TCC:

18588725

GRA:

105802444

GHI:	107911782 107924335

GAB:

108473730

HSYR:

120181586 120213122

DZI:	111291758 111316641

EGR:

104448212

GMX:	100500353 100815533 102663789

GSJ:	114394443 114395924 114396937

PVU:

VRA:

VAR:

VUN:

VUM:

CCAJ:

APRC:

MTR:

TPRA:

CAM:

PSAT:

VVO:

LJA:

ADU:

AIP:

AHF:	112701940 112765474

LANG:

109361172

PCIN:

129302921

QSA:	O6P43_021191

FVE:

AANS:

RCN:

PPER:

PMUM:

PAVI:

PDUL:

MDM:	103443259 103448480

MSYL:

PXB:

ZJU:

MNT:

CSAV:

CSV:

CMO:

BHJ:

MCHA:

CMAX:

CMOS:

CPEP:

RCU:

MEAN:

JCU:

HBR:	110657738 110673472

MESC:

110612383

POP:	7463852 7482280

PEU:	105126305 105141760

PALZ:

118027689 118047050

PNZ:	133679395 133698878

JRE:

CILL:

CAVE:

QSU:

QLO:

TWL:

VVI:

VRI:

SLY:

SPEN:

SOT:

SSTN:

SDUL:

CANN:

LBB:

NTA:	107772419 107825612

NSY:

104224117

NTO:

104100130

NAU:

109238818

INI:	109178039 109187869

ITR:

116011084

SIND:

105176677

OEU:	111376508 111397347

EGT:

SSPL:

SHIS:

APAN:

HAN:	110873597 110942082

ECAD:

122611066

LSV:	111877621 111883571

CCAV:

DCR:

CSIN:

RVL:

AEW:	130755936 130762980

BVG:

104897872

SOE:	110786904 110788079

CQI:	110725814 110735762

ATRI:

MOF:

NNU:

MING:

TSS:

PSOM:

OSA:

OBR:

OGL:

BDI:

ATS:

TDC:	119285158 119290949

TAES:

123085324 123092717 123098015

TUA:

125552354

LPER:

127296185

LRD:	124695222 124701950

SBI:

8054317

ZMA:	100501537 103640234

MFLO:

136502671 136540238 136548230

SITA:

SVS:

PVIR:

PHAI:

PDA:

EGU:

MUS:

ZOF:	121989829 121998784 121998787 122007368 122036745

DCT:

PEQ:

AOF:

MSIN:

ACAK:

NCOL:

ATR:

CJF:

SMO:	SELMODRAFT_175228 SELMODRAFT_89407

PPP:

112291012

VCN:	VOLCADRAFT_67859

CSL:	COCSUDRAFT_28990

CVR:	CHLNCDRAFT_55988

APRO:

F751_6318

OLU:	OSTLU_26336

OTA:	OT_ostta11g00080

BPG:	Bathy18g01500

MIS:	MICPUN_87151

MPP:	MICPUCDRAFT_48216

CME:	CYME_CMO097C

CCP:	CHC_T00001287001

SCE:	YBR248C(HIS7)

SEUB:

DI49_1272

SPAO:

SPAR_B03440

AGO:	AGOS_AFL046W

ERC:

Ecym_2250

KLA:	KLLA0_F06578g

KMX:	KLMA_20413(HIS7)

LTH:	KLTH0H05368g

ZRO:	ZYRO0G21978g

CGR:	2886949(GVI51_C01353)

NCS:	NCAS_0H01160(NCAS0H01160)

NDI:	NDAI_0F02140(NDAI0F02140)

TPF:	TPHA_0J02100(TPHA0J02100)

TGB:	HG536_0D01840

TDL:	TDEL_0B03860(TDEL0B03860)

KAF:	KAFR_0G03620(KAFR0G03620)

KNG:	KNAG_0M00520(KNAG0M00520)

ZMK:	HG535_0B01750

SLUD:

SCDLUD_001046

DHA:	DEHA2A04488g

PIC:	PICST_65481(HIS7)

PGU:	PGUG_00207

SPAA:

SPAPADRAFT_63608

LEL:	PVL30_005255(HIS7)

LBG:	92211230(LODBEIA_P60340)

CAL:	CAALFM_C703720CA(HIS7)

CTP:	CTRG_06234

COT:	CORT_0G03330

CDU:	CD36_73390(HIS7)

CTEN:

18245728(HIS7)

CLU:	CLUG_00518

CLUS:

A9F13_15g01232

PPA:	PAS_chr4_0703

PKZ:	C5L36_0C02050

BNN:	FOA43_002005(HIS7)

BBRX:

BRETT_004013(HIS7)

OPA:	HPODL_00324

YLI:	2910043(YALI2_C00124g)

SLB:	AWJ20_329(HIS7)

NCR:	NCU07156(his-6)

NTE:	NEUTE1DRAFT74784(NEUTE1DRAFT_74784)

SMP:	10801927(SMAC4_06935)

PAN:	PODANSg204

PBEL:

QC761_213640(HIS7)

PPSD:

QC762_213640(HIS7)

PPSP:

QC763_213640(HIS7)

PPSA:

QC764_213640(HIS7)

TTT:	THITE_2109223

MTM:	MYCTH_2303002

CTHR:

MGR:

PPEI:

PGRI:

TMN:	UCRPA7_304

SSCK:

SPSK_09025

FGR:	FGSG_09984

FPU:	FPSE_03883

FPOA:

FPOAC1_003062

FVN:	FVRRES_03393

FVR:	FVEG_02795

FOX:	FOXG_05335

NHE:	NECHADRAFT_41455

FFC:	NCS54_00712700

FKR:	NCS57_00752800

FMU:	J7337_005709

TRE:	TRIREDRAFT_81188

TRR:	M419DRAFT_26312

TATV:

25785652(TrAtP1_006819)

TASP:

36610861(TrAFT101_006031)

MAW:	19246905(HIS7_1)

MAJ:

MAA_03044

MBRN:

26241464(hisHF)

PCHM:

VFPPC_09573

CMT:

CCM_04678

AMUS:

LMH87_009154

PLJ:	28890624(PLICBS_005020)

PTKZ:

JDV02_006854(HIS7)

VAL:	VDBG_00410

VDA:	VDAG_00021

CFJ:	CFIO01_04422

CLUP:

CLUP02_10440

CHIG:

CH63R_09199

CDET:

87950389(CDEST_13889)

SAPO:

SAPIO_CDS10677

ELA:	UCREL1_6713

PFY:	PFICI_13103

SSL:	SS1G_05116

BFU:	BCIN_09g02000(Bchis7)

MBE:

MBM_08882

PSCO:

LY89DRAFT_587692

GLZ:	GLAREA_11034

ANI:	ANIA_07430

AFM:	AFUA_2G06230

ACT:	ACLA_068080

NFI:	NFIA_083020

AOR:	AO090001000740

ANG:	An02g14890

AFV:	AFLA_012876

ALUC:

AKAW2_11247S(HIS7)

ACHE:

ACHE_80234S(HIS7)

APUU:

APUU_80620S(HIS7)

PCS:	N7525_007717

PDP:	PDIP_56810

POU:	POX_h09567

TMF:	EYB26_001308

TRG:	TRUGW13939_06083

CIM:	CIMG_07226

CPW:	9695849(HIS7)

URE:	UREG_05681

ABE:

ARB_02630

TVE:

TRV_03046

PBL:	PAAG_00285

PBN:	PADG_07845

AJE:	HCAG_02035

BGH:	BDBG_09497

PNO:	SNOG_15843

PTE:

PTT_13691

PTRR:

6338963(PtrM4_028840)

BZE:	COCCADRAFT_8530

BSC:	COCSADRAFT_85214

BOR:	COCMIDRAFT_83723

AALT:

CC77DRAFT_951205

ARAB:

EKO05_0000363

ZTR:	MYCGRDRAFT_43769

PFJ:	MYCFIDRAFT_76997

FFU:	CLAFUR5_09464

CBET:

CB0940_10454

BCOM:

BAUCODRAFT_123100

NPA:	UCRNP2_7492

TML:	GSTUM_00005498001

SPO:	2541224(his4)

SOM:	SOMG_00138(his4)

CNE:

CNA07220

CNB:

CNBA7020

CNG:	CNAG_00743

CGI:	CGB_A8310C

CDEU:

CNBG_1189

KMG:	30166580(I203_100699)

KNE:	92181534(IAR55_004276)

TMS:	TREMEDRAFT_73645

TASA:

A1Q1_06985

CCAC:

CcaHIS019_0106440(HIS7)

TVS:	TRAVEDRAFT_137683 TRAVEDRAFT_54712 TRAVEDRAFT_62114

DSQ:	DICSQDRAFT_131060

PCO:	PHACADRAFT_168512

SHS:	STEHIDRAFT_88808

HIR:	HETIRDRAFT_306558

PSQ:	PUNSTDRAFT_80273

ADL:	AURDEDRAFT_50749

FME:	FOMMEDRAFT_81639

GTR:	GLOTRDRAFT_52855

RSX:	RhiXN_00351

LBC:	LACBIDRAFT_181495

CCI:	CC1G_10536

ABP:	AGABI1DRAFT66258(AGABI1DRAFT_66258)

ABV:	AGABI2DRAFT215018(AGABI2DRAFT_215018)

PCUB:

JR316_0001065

MPR:	MPER_08139

MRR:	Moror_17186

E1B28_001017

SCM:	SCHCO_02612243(SCHCODRAFT_02612243)

CPUT:

CONPUDRAFT_86721

SLA:	SERLADRAFT_448984

WSE:	WALSEDRAFT_59342

WIC:	J056_001605

UMA:	UMAG_03858

PFP:	PFL1_06439

SGRA:

MGL:

MRT:

MSYM:

PGR:	PGTG_12934 PGTG_12960

PTRC:

PtA15_3A126

PSTR:

Pst134EA_007736

MLR:	MELLADRAFT_76906

RIE:	OCT59_022755

MBR:	MONBRDRAFT_16620

SRE:	PTSG_04501

PTI:	PHATRDRAFT_19324

FCY:	FRACYDRAFT_195266

TPS:	THAPSDRAFT_30478(hisH)

AAF:	AURANDRAFT_34011

PIF:	PITG_05245

PSOJ:

PHYSODRAFT_351517

BLAC:

94353407(CCR75_009697)

SPAR:

SPRG_00441

EHX:	EMIHUDRAFT_426730

GTT:	GUITHDRAFT_159622

ALV:	Alvin_1138

ATEP:

Atep_13830

TVI:	Thivi_3177

TMB:	Thimo_1857

MPUR:

MARPU_10750

TSY:	THSYN_26000

TTP:	E6P07_07595(hisF)

THIP:

N838_09350

CJAP:

GWK36_11175(hisF)

THIM:

KFB96_02470(hisF)

TBOG:

LT988_24050(hisF)

DPS:

DP2167

DSF:

UWK_03250

DAK:	DaAHT2_2087

DPR:	Despr_1027

DEO:	CAY53_11430

DOG:	HP555_13735(hisF)

DTO:	TOL2_C40970(hisHF)

DOV:	DSCO28_19320

DWD:	DSCW_13020

DALK:

DSCA_04360

DML:	Dmul_08250(hisHF)

DAX:	FDQ92_14055(hisF)

TID:	Thein_0970

TMAI:

FVE67_08195(hisF)

» show all

Reference

PMID:8366040

Authors

Kuenzler M, Balmelli T, Egli CM, Paravicini G, Braus GH

Title

Cloning, primary structure, and regulation of the HIS7 gene encoding a bifunctional glutamine amidotransferase: cyclase from Saccharomyces cerevisiae.

Journal

J Bacteriol 175:5548-58 (1993)
DOI:10.1128/JB.175.17.5548-5558.1993

Reference

PMID:12795595

Authors

Chaudhuri BN, Lange SC, Myers RS, Davisson VJ, Smith JL

Title

Toward understanding the mechanism of the complex cyclization reaction catalyzed by imidazole glycerolphosphate synthase: crystal structures of a ternary complex and the free enzyme.

Journal

Biochemistry 42:7003-12 (2003)
DOI:10.1021/bi034320h

Sequence

[sce:YBR248C]

LinkDB

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