KEGG   ORTHOLOGY: K00054
Entry
K00054                      KO                                     
Symbol
mvaA
Name
hydroxymethylglutaryl-CoA reductase [EC:1.1.1.88]
Pathway
map00900  Terpenoid backbone biosynthesis
map01110  Biosynthesis of secondary metabolites
Module
M00849  C5 isoprenoid biosynthesis, mevalonate pathway, archaea
Reaction
R02081  (R)-mevalonate:NAD+ oxidoreductase (CoA-acetylating)
Brite
KEGG Orthology (KO) [BR:ko00001]
 09100 Metabolism
  09109 Metabolism of terpenoids and polyketides
   00900 Terpenoid backbone biosynthesis
    K00054  mvaA; hydroxymethylglutaryl-CoA reductase
Enzymes [BR:ko01000]
 1. Oxidoreductases
  1.1  Acting on the CH-OH group of donors
   1.1.1  With NAD+ or NADP+ as acceptor
    1.1.1.88  hydroxymethylglutaryl-CoA reductase
     K00054  mvaA; hydroxymethylglutaryl-CoA reductase
Other DBs
COG: COG1257
GO: 0042282
Genes
STEK: AXG53_08000
LFX: LU699_17870
RHD: R2APBS1_3947
RTH: LRK53_02345
DYE: EO087_12940
DCS: ISN74_17590
PCQ: PcP3B5_30960(mvaA)
PPF: Pput_3073
PPI: YSA_09663
PBRE: QDY63_12895
PTAE: NCTC10697_02276(mvaA)
PSTT: CH92_10110
MBS: MRBBS_1941(mvaA)
PALI: A3K91_0944
AGU: AS4_30260(mvaA)
ABOU: ACBO_21810
LPN: lpg2052
LPH: LPV_2355(mvaA)
LPO: LPO_2155(mvaA)
LPM: LP6_2032(mvaA)
LPF: lpl2030
LPP: lpp2035
LPC: LPC_1538(mvaA)
LPA: lpa_02994
LPE: lp12_1993
LLO: LLO_2093(mvaA)
LFA: LFA_1198(hmgA) LFA_2262(mvaA)
LHA: LHA_2668(hmgA)
LOK: Loa_02632
LCD: clem_02920(mvaA)
LLG: 44548918_02234(mvaA)
LJR: NCTC11533_02313(mvaA)
LCJ: NCTC11976_02826(mvaA)
LWA: SAMEA4504053_2305(mvaA_1) SAMEA4504053_2440(mvaA_2)
LSS: NCTC12082_01446(mvaA)
LADL: NCTC12735_01483(mvaA)
TMC: LMI_2739(hmgA)
HAM: HALO0597
HAAH: HALA3H3_510030(hmgA)
ALCA: ASALC70_02192(mvaA_2)
ADI: B5T_00170
AXE: P40_00835
APAC: S7S_00595
SALN: SALB1_2160
CGD: CR3_3190(mvaA)
BCJ: BCAM0531(mvaA)
BCEO: I35_4422(mvaA)
BCED: DM42_4560
BSEM: WJ12_22645
BGO: BM43_7175
CABK: NK8_42860
BPT: Bpet3342(mvaA)
AXX: ERS451415_03082(mvaA)
PUT: PT7_1301
AMIM: MIM_c08330(hmgA1)
DAC: Daci_0287
HYB: Q5W_13825
HSE: Hsero_3034(mvaA)
HRB: Hrubri_3051(mvaA)
MESJ: MJ8_11920
SHZ: shn_25545
MAQU: Maq22A_c21635(hmg1)
MIND: mvi_53600
LABT: FIU93_07605(mvaA)
SIL: SPOA0163(mvaA)
SPSE: SULPSESMR1_00707(mvaA)
LALG: LentiSH36_02213(mvaA)
RSU: NHU_01014
PGV: SL003B_3247(mvaA)
TMO: TMO_a0224(mvaA)
MXA: MXAN_5020
CCX: COCOR_02446(mvaA)
SCL: sce3010
BBA: Bd1627
BBAT: Bdt_1616
BBW: BDW_05675
BBAC: EP01_04340
BEX: A11Q_1500
BMX: BMS_1477(mvaA)
HAX: BALOs_1465(mvaA)
OIH: OB0224
AXL: AXY_13140
VPN: A21D_01101(mvaA)
BCK: BCO26_0196(mvaA)
BAG: Bcoa_1063
BCOA: BF29_2664
SAU: SA2333(mvaA)
SAV: SAV2545(mvaA)
SAW: SAHV_2529(mvaA)
SAM: MW2466(mvaA)
SAS: SAS2431
SAR: SAR2625(mvaA)
SAC: SACOL2560
SAE: NWMN_2445(mvaA)
SAD: SAAV_2611
SUK: SAA6008_02583(mvaA)
SUZ: MS7_2550
SUX: SAEMRSA15_24480(mvaA)
SUW: SATW20_26670(mvaA)
SUG: SAPIG2595
SUF: SARLGA251_23200(mvaA)
SAUA: SAAG_00366
SAUE: RSAU_002385(mvaA)
SAUS: SA40_2297(mvaA)
SAUU: SA957_2381(mvaA)
SAUG: SA268_2459(mvaA)
SAUZ: SAZ172_2644(mvaA)
SAUT: SAI1T1_2018940(mvaA)
SAUJ: SAI2T2_1018950(mvaA)
SAUK: SAI3T3_1018940(mvaA)
SAUQ: SAI4T8_1018950(mvaA)
SAUF: X998_2528
SAB: SAB2419c(mvaA)
SUY: SA2981_2481(mvaA)
SAUB: C248_2602(mvaA)
SAUC: CA347_2619
SAUR: SABB_01137(mvaA)
SAUI: AZ30_13340
SAUD: CH52_06275
SAMS: NI36_12725
SER: SERP2121
SEP: SE_2109
SEPP: SEB_02114
SEPS: DP17_1049
SHA: SH0511(mvaA)
SHH: ShL2_00409(mvaA)
SSP: SSP0326
SCA: SCA_1883(mvaA)
SLN: SLUG_04440(mvaA)
SPAS: STP1_1045
SXO: SXYL_00360(mvaA)
SCAP: AYP1020_1714(mvaA)
SARL: SAP2_04480
SPIC: SAMEA4384060_0646(mvaA)
SSH: NCTC13712_02499(mvaA)
SSIM: SAMEA4384339_2347(mvaA)
STAP: AOB58_2189
LMO: lmo0825
LMOE: BN418_0971
LMOB: BN419_0975
LMOD: LMON_0829
LMOW: AX10_12665
LMR: LMR479A_0843(mvaA)
LMOM: IJ09_06205
LMOG: BN389_08550(mvaA)
LMP: MUO_04395
LMOX: AX24_01440
LMQ: LMM7_0856(mvaA)
LMS: LMLG_2491
LMOK: CQ02_04315
LIN: lin0821
LWE: lwe0819(mvaA)
LSG: lse_0725
LIV: LIV_0764
GMO: NCTC11323_00064(mvaA)
GHA: NCTC10459_01687(mvaA)
LLA: L10433(mvaA)
LLK: LLKF_1694(mvaA)
LLT: CVCAS_1478(mvaA)
LLS: lilo_1494(mvaA)
LLX: NCDO2118_1591(mvaA)
LLJ: LG36_1520(mvaA)
LLM: llmg_0931(mvaA)
LLC: LACR_1664
LLR: llh_4680
LLI: uc509_1525(mvaA)
LLW: kw2_1526
LGR: LCGT_1220
LGV: LCGL_1241
LPET: lgb_01251(mvaA)
SPY: SPy_0880(mvaS.1)
SPYA: A20_0727c(mvaS.1)
SPM: spyM18_0941(mvaS1)
SPG: SpyM3_0599(mvaS.1)
SPS: SPs1254
SPF: SpyM51122(mvaA)
STG: MGAS15252_0711(mvaS1)
STX: MGAS1882_0707(mvaS1)
SOZ: Spy49_0694c(mvaS1)
SPYH: L897_03595
SPN: SP_1726
SPD: SPD_1536
SPR: spr1570(mvaA)
SPW: SPCG_1698(mvaA)
SJJ: SPJ_1621
SNV: SPNINV200_15480(mvaA)
SPX: SPG_1631(mvaA)
SNT: SPT_1664
SND: MYY_1645
SPNN: T308_07880
SNE: SPN23F17270(mvaA)
SPV: SPH_1835
SNI: INV104_14710(mvaA)
SPNG: HMPREF1038_01706(mvaA)
SNP: SPAP_1731
SNX: SPNOXC15180(mvaA)
SNU: SPNA45_00517(mvaA)
SPNE: SPN034156_06050(mvaA)
SPNU: SPN034183_15150(mvaA)
SPNM: SPN994038_15040(mvaA)
SPNO: SPN994039_15050(mvaA)
SAG: SAG1317
SAN: gbs1387
SAK: SAK_1348
SGC: A964_1231
SAGM: BSA_13960
SAGI: MSA_14380
SAGR: SAIL_13620
SAGP: V193_05815
SAGC: DN94_05815
SAGE: EN72_07345
SAGG: EN73_06475
SAGN: W903_1330
SMU: SMU_942(mvaA)
SMC: SmuNN2025_1085(mvaA)
SMJ: SMULJ23_1083(mvaA)
SMUA: SMUFR_0820
STC: str0576(mvaA)
STL: stu0576(mvaA)
STE: STER_0620
STN: STND_0576
STU: STH8232_0760(mvaA)
STW: Y1U_C0553
STHE: T303_04035
SSA: SSA_0337(mvaA)
SSB: SSUBM407_1530(mvaA)
SSI: SSU1454(mvaA)
SSS: SSUSC84_1483(mvaA)
SUP: YYK_06950
SST: SSUST3_1488(mvaA)
SSUY: YB51_7335
SSK: SSUD12_1597(mvaA)
SSQ: SSUD9_1651(mvaA)
SRP: SSUST1_1521(mvaA)
SSUT: TL13_1441(mvaA)
SSUI: T15_1655
SGO: SGO_0243
SEZ: Sez_1080(hmgA)
SEQ: SZO_08870
SEQU: Q426_03685
SEU: SEQ_1108
SUB: SUB0769(mvaA)
SDS: SDEG_0842(mvaS1)
SDA: GGS_0809(mvaS1)
SDC: SDSE_0879(mvaA)
SGG: SGGBAA2069_c12510(mvaA)
SGT: SGGB_1254(mvaA)
SMB: smi_1618
SOR: SOR_1536
STK: STP_0604(mvaA)
STB: SGPB_1170(mvaA)
SCF: Spaf_1822(hmg1)
SSR: SALIVB_1511(mvaA)
STJ: SALIVA_0586(mvaA)
SSAH: HSISS4_00495(mvaA)
SMN: SMA_1189(mvaA)
SIF: Sinf_1091
SIE: SCIM_0185(mvaA)
SIB: SIR_0243
SIU: SII_0229
SANG: SAIN_0168
SANC: SANR_0192
SANS: DK43_09280
SCG: SCI_0246
SCON: SCRE_0226
SCOS: SCR2_0226
SIK: K710_1153
SLU: KE3_1153
STRN: SNAG_1501(mvaA)
STRG: SRT_11520(mvaA) SRT_11530(mvaA)
SVB: NCTC12167_00608(mvaA)
SMEN: SAMEA4412692_1229(mvaA)
SFER: NCTC12278_01037(mvaA)
SCAI: NCTC12191_01809(mvaA)
SPSU: NCTC13786_02079(mvaA)
SPOC: NCTC10925_01058(mvaA)
SAUP: NCTC3168_01009(mvaA)
SURN: NCTC13766_00981(mvaA)
SACO: SAME_01482(mvaA)
SVF: NCTC3166_01739(mvaA)
STOY: STYK_15620(mvaA)
SMIE: NCTC11169_00165(mvaA)
SPAM: SP4011_04990(mvaA)
LJO: LJ_1608
LJF: FI9785_1399(mvaA)
LJH: LJP_1347c
LAC: LBA0627(hmdH)
LAD: LA14_0656
LAF: SD55_0651(hmdH)
LDB: Ldb0880(mvaA)
LBU: LBUL_0805
LDL: LBU_0749
LGA: LGAS_1373
LHE: lhv_0662
LHL: LBHH_1490
LHV: lhe_0591
LHH: LBH_0531
LHD: HUO_08890
LCR: LCRIS_00631(mvaA)
LAM: LA2_03245
LKE: WANG_1020
LAE: LBAT_1227
LPW: LpgJCM5343_13710(mvaA)
LXO: KIM322_04590(hmdH)
LCA: LSEI_1786
LCS: LCBD_1982
LCE: LC2W_1961
LCW: BN194_19690(mvaA)
LPAP: LBPC_1702
LCB: LCABL_20040(mvaA)
LRH: LGG_01838(mvaA)
LRG: LRHM_1772
LRL: LC705_01821(mvaA)
LRA: LRHK_1814
LPL: lp_0447(mvaA)
LPJ: JDM1_0375(mvaA)
LPT: zj316_0610(mvaA)
LPS: LPST_C0374(mvaA)
LPZ: Lp16_0401
LRE: Lreu_0206
LRF: LAR_0196
LRT: LRI_1750
LFE: LAF_0181
LFR: LC40_0132
LFF: LBFF_0196
LSN: LSA_03920(hmgA)
LBH: Lbuc_1608
LBN: LBUCD034_1666(mvaA)
LHIL: G8J22_01897(mvaA)
LBR: LVIS_0450
LSL: LSL_0224
LSI: HN6_00218
LRM: LRC_04410
PPE: PEPE_0258
PPEN: T256_01395
PCE: PECL_85
LSA: LCA_1485(mvaA)
OOE: OEOE_1799
LME: LEUM_0335
LMM: MI1_01420
LMK: LMES_0276
LCI: LCK_00238(mvaA)
LKI: LKI_04880
LGS: LEGAS_1641(mvaA)
WKO: WKK_03895
WCE: WS08_0010
WCT: WS74_0009
WSO: WSWS_01541(mvaA)
XAP: XA3_13240
EFA: EF1364
EFL: EF62_1816
EFI: OG1RF_11152(atoB)
EFS: EFS1_1184
EFQ: DR75_438
EFM: M7W_1579
EHR: EHR_13740
ECAS: ECBG_04249
EMU: EMQU_1046
EDU: LIU_06210
ECEC: NCTC12421_01572(atoB)
MPS: MPTP_1924
MPX: MPD5_1720
THL: TEH_20240(mvaE)
VLC: G314FT_11480(mvaA)
CRN: CAR_c19390(mvaA)
CML: BN424_3178(mvaA)
CARC: NY10_1147
JDA: BW727_101330(mvaA)
CCT: CC1_27080
NCD: ACONDI_02292(mvaA)
KME: H0A61_01511(mvaA)
ERH: ERH_0085(mvaA)
ACL: ACL_0223
AOC: Aocu_12430(mvaA)
AHK: NCTC10172_00895(mvaA)
APAL: BN85412030(mvaA)
RER: RER_34980(mvaA)
REY: O5Y_15990
RHS: A3Q41_04793(mvaA)
NAL: B005_5093
SIJ: SCIP_0385
PDO: PSDT_1156
RCA: Rcas_0981
CAU: Caur_0236
CAG: Cagg_1141
HAU: Haur_3539
ATM: ANT_28820(mvaA)
ABAT: CFX1CAM_0206(mvaA)
CAP: CLDAP_37800(mvaA)
PBF: CFX0092_A1660(hmgA)
WCH: wcw_1117(mvaA)
BBU: BB_0685
BBUR: L144_03365
BGA: BG0708(mvaA)
BGB: KK9_0718(mvaA)
BGN: BgCN_0713
BAF: BAPKO_0729(mvaA)
BAFH: BafHLJ01_0755(mvaA)
BAFT: P612_03540
BAFE: BAFK78_694(mvaA)
BCHI: OY14_03430
BTU: BT0685
BHR: BH0685
BDU: BDU_688(mvaA)
BRE: BRE_691(mvaA)
BCW: Q7M_694
BMIY: RJ61_03360
BPAK: X966_03480
BANE: N187_03380
BOQ: BKFM_00684(mvaA)
BFAI: BOFE_01880
LBA: Lebu_0850
SMF: Smon_1290
BLQ: L21SP5_00850(mvaA)
ANF: AQPE_1844
MBAS: ALGA_1993
SGN: SGRA_3436
GFO: GFO_2973(hmgA)
GFL: GRFL_1008
FPS: FP2341(mvaA)
FJO: Fjoh_1418
FJG: BB050_01197(mvaA)
FBR: FBFL15_0427(mvaA)
FIN: KQS_01500(mvaA)
FSN: GS03_00968(mvaA)
FAO: SHINM13_08700(mvaA)
FAN: GENT5_08230(mvaA)
FOK: KK2020170_04050(mvaA)
COC: Coch_1037
ZPR: ZPR_0646
MARM: YQ22_05670
CBAL: M667_02450
CBAT: M666_02445
DOK: MED134_00855(mvaA)
DDO: I597_0094(mvaA)
ZGA: ZOBELLIA_1191(mvaA)
NDO: DDD_2040(hmgA)
NMF: NMS_1434
PHG: KCTC32516_01348(mvaA)
MYR: MYRA21_1563(mvaA)
MPW: MPR_0385
WIN: WPG_1915
TMAR: MARIT_2591(mvaA)
AALG: AREALGSMS7_00744(mvaA)
KOS: KORDIASMS9_00482(mvaA)
KAN: IMCC3317_23820(mvaA)
MARF: CJ739_2286
MESQ: C7H62_0704
MLT: VC82_984
SPON: HME9304_01002(mvaA)
FBA: FIC_02280
FBU: UJ101_00631(mvaA)
RAI: RA0C_1861
RAR: RIA_0620
RAG: B739_0303
RAE: G148_2020
RAT: M949_0745
EAO: BD94_0681
ELB: VO54_01997(mvaA)
CHZ: CHSO_4259
CGLE: NCTC11432_02579(mvaA)
CTAI: NCTC12078_01185(mvaA)
CTAK: 4412677_02320(mvaA)
CSAL: NBC122_01183(mvaA)
CJG: NCTC13459_02490(mvaA)
CANT: NCTC13489_02506(mvaA)
BPOR: BPO_0613(mvaA)
PTAN: CRYO30217_02152(mvaA)
CABY: Cabys_3842
AFU: AF_1736
FPL: Ferp_1542
GAC: GACE_1860
GAH: GAH_00518
MTP: Mthe_0936
MCJ: MCON_2640(mvaA)
MHI: Mhar_2045
MPD: MCP_0218(hmgA-1)
MEZ: Mtc_0274(hmgA-1)
RCI: RCIX376(hmgA)
HALH: HTSR_0034
HHSR: HSR6_0034(hmgA)
HSU: HLASF_0036(mvaA)
HSF: HLASA_0036(mvaA)
HAHS: HSRCO_0078(hmg1)
MELU: MTLP_08900
TAC: Ta0406
TVO: TVG1221182(TVG1221182)
PTO: PTO1143
FAI: FAD_1189
CDIV: CPM_1100
ABI: Aboo_1461
SMR: Smar_0178
DKA: DKAM_0720
TAG: Tagg_0332
IAG: Igag_1535
TPE: Tpen_0927
KCR: Kcr_0563
NMR: Nmar_1560
NID: NPIRD3C_0092(hmgA)
NIN: NADRNF5_0331(hmgA)
NCT: NMSP_0200(hmgA)
NGA: Ngar_c30640(mvaA)
NVN: NVIE_023590(mvaA)
NEV: NTE_03194
TAA: NMY3_00751(mvaA)
NFN: NFRAN_1757(hmgA)
NCV: NCAV_0171(hmgA)
NDV: NDEV_1923(hmgA)
NBV: T478_1287
CCAI: NAS2_1471
BARC: AOA65_0748 AOA65_0762(hmgA)
BARB: AOA66_0364(hmgA)
LOKI: Lokiarch_22660(mvaA)
AG: AAA25837(mvaA)
 » show all
Reference
PMID:2656635
  Authors
Beach MJ, Rodwell VW
  Title
Cloning, sequencing, and overexpression of mvaA, which encodes Pseudomonas mevalonii 3-hydroxy-3-methylglutaryl coenzyme A reductase.
  Journal
J Bacteriol 171:2994-3001 (1989)
DOI:10.1128/jb.171.6.2994-3001.1989
  Sequence
LinkDB

DBGET integrated database retrieval system