KEGG   DRUG: Sunvozertinib
Entry
D12506                      Drug                                   
Name
Sunvozertinib (USAN/INN)
Formula
C29H35ClFN7O3
Exact mass
583.2474
Mol weight
584.08
Structure
Class
Antineoplastic
 DG01918  Tyrosine kinase inhibitor
  DG01917  Receptor tyrosine kinase inhibitor
   DG03162  EGFR inhibitor
Efficacy
Antineoplastic, Receptor tyrosine kinase inhibitor
Comment
Treatment of non-small cell lung cancer
Target
EGFR* [HSA_VAR:1956v2] [HSA:1956] [KO:K04361]
  Pathway
hsa04010  MAPK signaling pathway
hsa04012  ErbB signaling pathway
hsa05200  Pathways in cancer
Interaction
Brite
Drug groups [BR:br08330]
 Antineoplastic
  DG01918  Tyrosine kinase inhibitor
   DG01917  Receptor tyrosine kinase inhibitor
    DG03162  EGFR inhibitor
     D12506  Sunvozertinib
Target-based classification of drugs [BR:br08310]
 Protein kinases
  Receptor tyrosine kinases (RTK)
   EGFR family
    EGFR* [HSA_VAR:1956v2]
     D12506  Sunvozertinib (USAN/INN)
Other DBs
CAS: 2370013-12-8
PubChem: 497620919
LinkDB
KCF data

ATOM        41
            1   C8y C    20.7991  -20.5153
            2   N5x N    20.7991  -21.9157
            3   C8y C    21.9894  -22.6159
            4   N5x N    23.2498  -21.9157
            5   C8x C    23.2498  -20.5153
            6   C8x C    21.9894  -19.8151
            7   N1b N    21.9722  -24.0162
            8   C8y C    23.1889  -24.7389
            9   C8x C    23.1718  -26.1169
            10  C8y C    24.3758  -26.8321
            11  C8y C    25.5972  -26.1471
            12  C8x C    25.6143  -24.7691
            13  C8y C    24.4104  -24.0538
            14  N1b N    19.5834  -19.8200
            15  C8y C    18.3947  -20.5130
            16  C8y C    17.1980  -19.8286
            17  C8x C    15.9880  -20.5337
            18  C8y C    15.9937  -21.9341
            19  C8y C    17.1904  -22.6185
            20  C8x C    18.4003  -21.9134
            21  X   F    14.7728  -22.6459
            22  C1d C    17.1920  -18.4152
            23  O1a O    17.1920  -17.0148
            24  C1a C    15.8616  -18.4152
            25  C1a C    18.6624  -18.4152
            26  X   Cl   17.1959  -24.0158
            27  O2a O    24.4281  -22.6860
            28  C1a C    25.6589  -21.9964
            29  N1b N    24.3585  -28.2175
            30  C5a C    23.1458  -28.8975
            31  O5a O    23.1977  -30.3171
            32  N1y N    26.8117  -26.8690
            33  C1x C    26.9420  -28.2822
            34  C1y C    28.3263  -28.5951
            35  C1x C    29.0516  -27.3751
            36  C1x C    28.1155  -26.3084
            37  N1c N    28.8750  -29.8703
            38  C1a C    30.2453  -30.0322
            39  C1a C    28.0159  -31.0219
            40  C2b C    21.9591  -28.2313
            41  C2a C    20.7834  -28.9292
BOND        44
            1     1   2 2
            2     2   3 1
            3     3   4 2
            4     4   5 1
            5     5   6 2
            6     1   6 1
            7     3   7 1
            8     7   8 1
            9     8   9 2
            10    9  10 1
            11   10  11 2
            12   11  12 1
            13   12  13 2
            14    8  13 1
            15    1  14 1
            16   14  15 1
            17   15  16 2
            18   16  17 1
            19   17  18 2
            20   18  19 1
            21   19  20 2
            22   15  20 1
            23   18  21 1
            24   16  22 1
            25   22  23 1
            26   22  24 1
            27   22  25 1
            28   19  26 1
            29   13  27 1
            30   27  28 1
            31   10  29 1
            32   29  30 1
            33   30  31 2
            34   11  32 1
            35   32  33 1
            36   33  34 1
            37   34  35 1
            38   35  36 1
            39   32  36 1
            40   34  37 1 #Up
            41   37  38 1
            42   37  39 1
            43   30  40 1
            44   40  41 2

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