KEGG   DRUG: Rosmantuzumab
Entry
D11369                      Drug                                   
Name
Rosmantuzumab (USAN)
Formula
C6456H9954N1714O2048S46
Exact mass
145733.4596
Mol weight
145823.44
Sequence
(Heavy chain)
QVQLVQSGAE VKKPGASVKV SCKASGYTFT DYSIHWVRQA PGQGLEWIGY IYPSNGDSGY
NQKFKNRVTM TRDTSTSTAY MELSRLRSED TAVYYCATYF ANNFDYWGQG TTLTVSSAST
KGPSVFPLAP SSKSTSGGTA ALGCLVKDYF PEPVTVSWNS GALTSGVHTF PAVLQSSGLY
SLSSVVTVPS SSLGTQTYIC NVNHKPSNTK VDKRVEPKSC DKTHTCPPCP APELLGGPSV
FLFPPKPKDT LMISRTPEVT CVVVDVSHED PEVKFNWYVD GVEVHNAKTK PREEQYNSTY
RVVSVLTVLH QDWLNGKEYK CKVSNKALPA PIEKTISKAK GQPREPQVYT LPPSREEMTK
NQVSLTCLVK GFYPSDIAVE WESNGQPENN YKTTPPVLDS DGSFFLYSKL TVDKSRWQQG
NVFSCSVMHE ALHNHYTQKS LSLSPGK
(Light chain)
DIQMTQSPSS LSASVGDRVT ITCKASQSVD YDGDSYMNWY QQKPGKAPKL LIYAASNLES
GVPSRFSGSG SGTDFTLTIS PVQAEDFATY YCQQSNEDPL TFGAGTKLEL KRTVAAPSVF
IFPPSDEQLK SGTASVVCLL NNFYPREAKV QWKVDNALQS GNSQESVTEQ DSKDSTYSLS
STLTLSKADY EKHKVYACEV THQGLSSPVT KSFNRGEC
(Disulfide bridge: H22-H96, H144-H200, H220-L218, H226-H'226, H229-H'229, H261-H321, H367-H425, H'22-H'96, H'144-H'200, H'220-L'218, H'261-H'321, H'367-H'425, L23-L92, L138-L198, L'23-L'92, L'138-L'198)
  Type
Peptide
Efficacy
Antineoplastic, Anti-RSPO3 protein antibody
  Type
Monoclonal antibody
Target
RSPO3 [HSA:84870] [KO:K23098]
  Pathway
hsa04310  Wnt signaling pathway
Brite
Target-based classification of drugs [BR:br08310]
 Not elsewhere classified
  Environmental information processing
   Wnt signaling
    RSPO3
     D11369  Rosmantuzumab (USAN)
Other DBs
CAS: 1684393-04-1
PubChem: 384585347
LinkDB

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