KEGG   DRUG: Teprotumumab
Entry
D09680                      Drug                                   
Name
Teprotumumab (USAN/INN);
Teprotumumab (genetical recombination) (JAN);
Teprotumumab-trbw;
Tepezza (TN)
Product
TEPEZZA (Horizon Therapeutics USA)
Formula
C6476H10012N1748O2000S40
Exact mass
145548.4297
Mol weight
145637.97
Sequence
(Heavy chain)
QVELVESGGG VVQPGRSQRL SCAASGFTFS SYGMHWVRQA PGKGLEWVAI IWFDGSSTYY
ADSVRGRFTI SRDNSKNTLY LQMNSLRAED TAVYFCAREL GRRYFDLWGR GTLVSVSSAS
TKGPSVFPLA PSSKSTSGGT AALGCLVKDY FPEPVTVSWN SGALTSGVHT FPAVLQSSGL
YSLSSVVTVP SSSLGTQTYI CNVNHKPSNT KVDKKVEPKS CDKTHTCPPC PAPELLGGPS
VFLFPPKPKD TLMISRTPEV TCVVVDVSHE DPEVKFNWYV DGVEVHNAKT KPREEQYNST
YRVVSVLTVL HQDWLNGKEY KCKVSNKALP APIEKTISKA KGQPREPQVY TLPPSRDELT
KNQVSLTCLV KGFYPSDIAV EWESNGQPEN NYKTTPPVLD SDGSFFLYSK LTVDKSRWQQ
GNVFSCSVMH EALHNHYTQK SLSLSPGK
(Light chain)
EIVLTQSPAT LSLSPGERAT LSCRASQSVS SYLAWYQQKP GQAPRLLIYD ASKRATGIPA
RFSGSGSGTD FTLTISSLEP EDFAVYYCQQ RSKWPPWTFG QGTKVESKRT VAAPSVFIFP
PSDEQLKSGT ASVVCLLNNF YPREAKVQWK VDNALQSGNS QESVTEQDSK DSTYSLSSTL
TLSKADYEKH KVYACEVTHQ GLSSPVTKSF NRGEC
(Disulfide bridge: H22-H96, H145-H201, H62-H322, H368-H426, H227-H'230, L23-L88, L135-L195, H221-L215)
  Type
Peptide
Remark
Therapeutic category: 1390
ATC code: L04AG13
Product: D09680<JP/US>
Efficacy
Anti-inflammatory, Insulin-like growth factor 1 receptor antibody
  Disease
Thyroid eye disease [DS:H02402]
  Type
Monoclonal antibody
Comment
Treatment of Graves' disease
Target
IGF1R (CD221) [HSA:3480] [KO:K05087]
Interaction
Brite
Anatomical Therapeutic Chemical (ATC) classification [BR:br08303]
 L ANTINEOPLASTIC AND IMMUNOMODULATING AGENTS
  L04 IMMUNOSUPPRESSANTS
   L04A IMMUNOSUPPRESSANTS
    L04AG Monoclonal antibodies
     L04AG13 Teprotumumab
      D09680  Teprotumumab (USAN/INN) <US>
USP drug classification [BR:br08302]
 Ophthalmic Agents
  Ophthalmic Agents, Other
   Teprotumumab
    D09680  Teprotumumab (USAN/INN)
Therapeutic category of drugs in Japan [BR:br08301]
 1  Agents affecting nervous system and sensory organs
  13  Agents affecting sensory organs
   139  Miscellaneous
    1390  Miscellaneous
     D09680  Teprotumumab (USAN/INN); Teprotumumab (genetical recombination) (JAN)
Target-based classification of drugs [BR:br08310]
 Protein kinases
  Receptor tyrosine kinases (RTK)
   INSR family
    IGF1R (CD221)
     D09680  Teprotumumab (USAN/INN) <JP/US>
New drug approvals in the USA [br08319.html]
 New molecular entities and new therapeutic biological products
  D09680
New drug approvals in Japan [br08318.html]
 Drugs with new active ingredients
  D09680
New drug approvals in the USA, Europe and Japan [br08328.html]
 Approval dates by FDA, EMA and PMDA
  D09680
Other DBs
CAS: 89957-37-9
PubChem: 124490420
LinkDB

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