KEGG   DRUG: Doxycycline
Entry
D00307                      Drug                                   
Name
Doxycycline (USP);
Doxycycline hydrate;
Monodox (TN);
Oracea (TN);
Vibramycin (TN)
Product
DOXYCYCLINE MONOHYDRATE (Chartwell RX), ORACEA (Galderma Laboratories), VIBRAMYCIN HYCLATE (Pfizer Laboratories Div Pfizer)
  Generic
DOXYCYCLINE (A-S Medication Solutions), DOXYCYCLINE (A-S Medication Solutions), DOXYCYCLINE (A-S Medication Solutions), DOXYCYCLINE (A-S Medication Solutions), DOXYCYCLINE (A-S Medication Solutions), DOXYCYCLINE (A-S Medication Solutions), DOXYCYCLINE (Alembic Pharmaceuticals Limited), DOXYCYCLINE (Alembic Pharmaceuticals Limited), DOXYCYCLINE (Alembic Pharmaceuticals), DOXYCYCLINE (Alembic Pharmaceuticals), DOXYCYCLINE (American Health Packaging), DOXYCYCLINE (American Health Packaging), DOXYCYCLINE (Apotex Corp.), DOXYCYCLINE (AvPAK), DOXYCYCLINE (Bryant Ranch Prepack), DOXYCYCLINE (Bryant Ranch Prepack), DOXYCYCLINE (Bryant Ranch Prepack), DOXYCYCLINE (Bryant Ranch Prepack), DOXYCYCLINE (Bryant Ranch Prepack), DOXYCYCLINE (Bryant Ranch Prepack), DOXYCYCLINE (Chartwell Governmental & Specialty RX), DOXYCYCLINE (Chartwell RX LLC), DOXYCYCLINE (Chartwell RX), DOXYCYCLINE (Cosette Pharmaceuticals), DOXYCYCLINE (DIRECT RX), DOXYCYCLINE (Denton Pharma), DOXYCYCLINE (Dr.Reddys Laboratories), DOXYCYCLINE (Golden State Medical Supply), DOXYCYCLINE (Golden State Medical Supply), DOXYCYCLINE (Heritage Pharmaceuticals Inc. d/b/a Avet Pharmaceuticals), DOXYCYCLINE (Lake Erie Medical DBA Quality Care Products LLC), DOXYCYCLINE (Lannett Company), DOXYCYCLINE (Lupin Pharmaceuticals), DOXYCYCLINE (Lupin Pharmaceuticals), DOXYCYCLINE (Lupin Pharmaceuticals), DOXYCYCLINE (Lupin Pharmaceuticals), DOXYCYCLINE (Mayne Pharma), DOXYCYCLINE (Medsource Pharmaceuticals), DOXYCYCLINE (Northwind Pharmaceuticals), DOXYCYCLINE (Northwind Pharmaceuticals), DOXYCYCLINE (Novel Laboratories), DOXYCYCLINE (NuCare Pharmaceuticals), DOXYCYCLINE (NuCare Pharmaceuticals), DOXYCYCLINE (PD-Rx Pharmaceuticals), DOXYCYCLINE (PD-Rx Pharmaceuticals), DOXYCYCLINE (PD-Rx Pharmaceuticals), DOXYCYCLINE (PD-Rx Pharmaceuticals), DOXYCYCLINE (PD-Rx Pharmaceuticals), DOXYCYCLINE (Par Pharmaceutical), DOXYCYCLINE (Prasco Laboratories), DOXYCYCLINE (Preferred Pharmaceuticals), DOXYCYCLINE (Proficient Rx LP), DOXYCYCLINE (Proficient Rx LP), DOXYCYCLINE (Proficient Rx LP), DOXYCYCLINE (Proficient Rx LP), DOXYCYCLINE (Proficient Rx LP), DOXYCYCLINE (Proficient Rx LP), DOXYCYCLINE (Proficient Rx LP), DOXYCYCLINE (Proficient Rx LP), DOXYCYCLINE (Quality Care Products), DOXYCYCLINE (Quality Care Products), DOXYCYCLINE (REMEDYREPACK), DOXYCYCLINE (REMEDYREPACK), DOXYCYCLINE (REMEDYREPACK), DOXYCYCLINE (RPK Pharmaceuticals), DOXYCYCLINE (RPK Pharmaceuticals), DOXYCYCLINE (RPK Pharmaceuticals), DOXYCYCLINE (RedPharm Drug), DOXYCYCLINE (RedPharm Drug), DOXYCYCLINE (RedPharm Drug), DOXYCYCLINE (Redpharm Drug), DOXYCYCLINE (Redpharm Drug), DOXYCYCLINE (Redpharm Drug), DOXYCYCLINE (Strides Pharma Science Limited), DOXYCYCLINE (Strides Pharma Science Limited), DOXYCYCLINE (Sun Pharmaceutical Industries), DOXYCYCLINE (Sun Pharmaceutical Industries), DOXYCYCLINE (Zydus Lifesciences Limited), DOXYCYCLINE (Zydus Lifesciences Limited), DOXYCYCLINE (Zydus Pharmaceuticals USA), DOXYCYCLINE (Zydus Pharmaceuticals USA), DOXYCYCLINE HYCLATE (Amneal Pharmaceuticals NY LLC), DOXYCYCLINE MONOHYDRATE (Advanced Rx Pharmacy of Tennessee), DOXYCYCLINE MONOHYDRATE (Aphena Pharma Solutions - Tennessee), DOXYCYCLINE MONOHYDRATE (Direct_Rx)
Formula
C22H24N2O8. H2O
Exact mass
462.1638
Mol weight
462.45
Structure
Simcomp
Class
Antibacterial
 DG01197  Tetracycline antibiotic
Remark
ATC code: A01AB22 J01AA02
Chemical structure group: DG00008
Product (DG00008): D00307<US> D02129<JP/US>
Efficacy
Antibacterial, Protein biosynthesis inhibitor
  Disease
Rocky Mountain spotted fever [DS:H00323]
Typhus fever [DS:H00322]
Q fever [DS:H00310]
Rickettsialpox [DS:H02379]
Lymphogranuloma venereum [DS:H00348]
Psittacosis [DS:H00350]
Trachoma [DS:H00349]
Relapsing fever [DS:H00427]
Chancroid [DS:H00305]
Plague [DS:H00297]
Tularemia [DS:H00312]
Cholera [DS:H00110]
Campylobacter fetus infections [DS:H00321]
Brucellosis [DS:H00325]
Bartonellosis [DS:H00326]
Granuloma inguinale [DS:H01415]
Anthrax [DS:H00328]
Gonorrhea [DS:H00315]
Syphilis [DS:H00354]
Yaws [DS:H01318]
Listeriosis [DS:H00332]
Vincent's infection [DS:H01440]
Actinomycosis [DS:H01325]
Amebiasis [DS:H00360]
Severe acne [DS:H01445]
Target
30S ribosomal subunit
  Pathway
ko03010  Ribosome
Interaction
Structure map
map07019  Tetracyclines
Brite
Anatomical Therapeutic Chemical (ATC) classification [BR:br08303]
 A ALIMENTARY TRACT AND METABOLISM
  A01 STOMATOLOGICAL PREPARATIONS
   A01A STOMATOLOGICAL PREPARATIONS
    A01AB Antiinfectives and antiseptics for local oral treatment
     A01AB22 Doxycycline
      D00307  Doxycycline (USP) <US>
 J ANTIINFECTIVES FOR SYSTEMIC USE
  J01 ANTIBACTERIALS FOR SYSTEMIC USE
   J01A TETRACYCLINES
    J01AA Tetracyclines
     J01AA02 Doxycycline
      D00307  Doxycycline (USP) <US>
USP drug classification [BR:br08302]
 Antibacterials
  Tetracyclines
   Doxycycline
    D00307  Doxycycline (USP)
 Dental and Oral Agents
  Doxycycline
   D00307  Doxycycline (USP)
Drug groups [BR:br08330]
 Antibacterial
  DG01197  Tetracycline antibiotic
   DG00008  Doxycycline
    D00307  Doxycycline
Drug classes [BR:br08332]
 Antibacterial
  DG01197  Tetracycline antibiotic
   D00307  Doxycycline
Antimicrobials [BR:br08307]
 Antibacterials
  Protein biosynthesis inhibitor
   Tetracycline
    D00307  Doxycycline (USP) <US>
Drug groups [BR:br08330]
 Antibacterial
  DG01197  Tetracycline antibiotic
   DG00008  Doxycycline
Antimicrobials abbreviations [BR:br08327]
 Antibacterials
  Protein biosynthesis inhibitor
   Tetracycline
    DG00008  Doxycycline
Other DBs
CAS: 17086-28-1
PubChem: 7847373
ChEBI: 60648
LigandBox: D00307
NIKKAJI: J243.853D
LinkDB
KCF data

ATOM        33
            1   C1y C    21.1216  -16.6614
            2   C1z C    21.1506  -18.0502
            3   C1y C    22.3391  -15.9818
            4   C1y C    19.9277  -15.9523
            5   C2y C    19.8983  -18.7358
            6   C5x C    22.2978  -18.7653
            7   C2y C    23.5269  -16.6969
            8   C1y C    18.7103  -16.6379
            9   C2y C    18.6985  -18.0324
            10  O1a O    19.8924  -20.1364
            11  C2y C    23.5151  -18.0857
            12  O5x O    22.3208  -20.1660
            13  O1a O    24.7564  -16.0173
            14  C1y C    17.5048  -15.9345
            15  C5x C    17.4929  -18.7298
            16  C5a C    24.7149  -18.8068
            17  C8y C    16.2990  -16.6261
            18  C8y C    16.2931  -18.0265
            19  O5x O    17.4929  -20.1245
            20  N1a N    25.9383  -18.1212
            21  O5a O    24.7439  -20.2073
            22  C8x C    15.0755  -15.9286
            23  C8y C    15.0815  -18.7240
            24  C8x C    13.8699  -16.6319
            25  C8x C    13.8699  -18.0324
            26  O1a O    15.0815  -20.1245
            27  C1a C    17.5101  -14.1705
            28  N1c N    22.3622  -13.7280
            29  C1a C    23.5981  -13.0412
            30  C1a C    21.1494  -13.0011
            31  O1a O    19.9173  -14.1846
            32  O1a O    21.0956  -19.4620
            33  O0  O    29.6802  -17.2901
BOND        35
            1     5   9 2
            2     5  10 1
            3     6  11 1
            4     6  12 2
            5     7  13 1
            6     8  14 1
            7     9  15 1
            8    11  16 1
            9    14  17 1
            10   15  18 1
            11   15  19 2
            12   16  20 1
            13   16  21 2
            14   17  22 1
            15   18  23 1
            16   22  24 2
            17   23  25 2
            18   23  26 1
            19    7  11 2
            20    8   9 1
            21   17  18 2
            22   24  25 1
            23   14  27 1 #Down
            24    3  28 1 #Down
            25    1   2 1
            26   28  29 1
            27    1   3 1
            28   28  30 1
            29    1   4 1
            30    2   5 1
            31    2   6 1
            32    4  31 1 #Down
            33    3   7 1
            34    2  32 1 #Down
            35    4   8 1

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