KEGG   ENZYME: 6.2.1.40
Entry
EC 6.2.1.40                 Enzyme                                 
Name
4-hydroxybutyrate---CoA ligase (AMP-forming);
4-hydroxybutyrate-CoA synthetase (ambiguous);
4-hydroxybutyrate:CoA ligase (ambiguous);
hbs (gene name);
4-hydroxybutyrate---CoA ligase
Class
Ligases;
Forming carbon-sulfur bonds;
Acid-thiol ligases
Sysname
4-hydroxybutanoate:CoA ligase (AMP-forming)
Reaction(IUBMB)
ATP + 4-hydroxybutanoate + CoA = AMP + diphosphate + 4-hydroxybutanoyl-CoA [RN:R09279]
Reaction(KEGG)
R09279
Substrate
ATP [CPD:C00002];
4-hydroxybutanoate [CPD:C00989];
CoA [CPD:C00010]
Product
AMP [CPD:C00020];
diphosphate [CPD:C00013];
4-hydroxybutanoyl-CoA [CPD:C11062]
Comment
Isolated from the archaeon Metallosphaera sedula. Involved in the 3-hydroxypropanoate/4-hydroxybutanoate cycle. cf. EC 6.2.1.56, 4-hydroxybutyrate---CoA ligase (ADP-forming).
History
EC 6.2.1.40 created 2014, modified 2019
Pathway
ec00720  Other carbon fixation pathways
ec01100  Metabolic pathways
ec01120  Microbial metabolism in diverse environments
Orthology
K14466  4-hydroxybutyrate---CoA ligase (AMP-forming)
K14467  4-hydroxybutyrate---CoA ligase (AMP-forming)
K18861  4-hydroxybutyrate---CoA ligase (AMP-forming)
K25774  4-hydroxybutyrate---CoA ligase (AMP-forming)
Genes
DLM: DPPLL_33240
AFU: AF_1287
AFG: AFULGI_00013960
APO: Arcpr_1040
GAC: GACE_0172
IHO: Igni_0475
IIS: EYM_04520
IPC: IPA_02910
PFM: Pyrfu_1031
PABI: PABY_06060
STO: STK_20950
SOH: D1869_11480
SSO: SSO1595(alkK-1)
SOL: Ssol_2425
SSOA: SULA_2450
SSOL: SULB_2451
SSOF: SULC_2448
SSHI: J5U23_01463
SCAS: SACC_13950 SACC_26260
SAI: Saci_2146
SACN: SacN8_05595 SacN8_10445
SACR: SacRon12I_05585 SacRon12I_10700
SACS: SUSAZ_05485 SUSAZ_09795
SIS: LS215_1135
SIA: M1425_0518
SIM: M1627_0847
SID: M164_0543
SIY: YG5714_0492
SII: LD85_0554
SIH: SiH_0833
SIR: SiRe_0517
SIC: SiL_0542
SULA: BFU36_11215
SULE: GFS03_05380
SULO: GFS33_10670
SULL: EWF20_12640
MSE: Msed_0394 Msed_0406 Msed_1422
MEMJ: MJ1HA_0488 MJ1HA_0500 MJ1HA_1635
MCN: Mcup_0813 Mcup_1674 Mcup_1685
MHK: DFR87_04145 DFR87_04415 DFR87_11765
MPRU: DFR88_04555 DFR88_04635 DFR88_11205
MTEN: GWK48_03480 GWK48_07380 GWK48_07475
MJN: MjAS7_1080 MjAS7_1095 MjAS7_2493
AHO: Ahos_0918 Ahos_2275
AMAN: B6F84_02735
ABRI: DFR85_01145 DFR85_14760 DFR85_15495
ASUL: DFR86_02735
AAMB: D1866_06370
ACIH: HS5_10870 HS5_22950
SAZO: D1868_09495
CSTY: KN1_05110 KN1_25190 KN1_28400
STEP: IC006_1474
SMET: RQ359_000462 RQ359_000992
PAI: PAE2474
PIS: Pisl_0250
PCL: Pcal_1386
PYR: P186_0721 P186_1145
POG: Pogu_1296
TNE: Tneu_0420
PYW: PYWP30_00438
TTN: TTX_1100(acsA)
TUZ: TUZN_0914
 » show all
Reference
1  [PMID:21169482]
  Authors
Ramos-Vera WH, Weiss M, Strittmatter E, Kockelkorn D, Fuchs G
  Title
Identification of missing genes and enzymes for autotrophic carbon fixation in crenarchaeota.
  Journal
J Bacteriol 193:1201-11 (2011)
DOI:10.1128/JB.01156-10
  Sequence
[tne:Tneu_0420]
Reference
2  [PMID:23258541]
  Authors
Hawkins AS, Han Y, Bennett RK, Adams MW, Kelly RM
  Title
Role of 4-hydroxybutyrate-CoA synthetase in the CO2 fixation cycle in thermoacidophilic archaea.
  Journal
J Biol Chem 288:4012-22 (2013)
DOI:10.1074/jbc.M112.413195
  Sequence
[mse:Msed_0406]
Other DBs
ExplorEnz - The Enzyme Database: 6.2.1.40
IUBMB Enzyme Nomenclature: 6.2.1.40
ExPASy - ENZYME nomenclature database: 6.2.1.40
BRENDA, the Enzyme Database: 6.2.1.40
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