KEGG ENZYME: 2.4.1.275

ENZYME: 2.4.1.275

Entry

EC 2.4.1.275                Enzyme

Name

neolactotriaosylceramide beta-1,4-galactosyltransferase;
beta4Gal-T4;
UDP-galactose:N-acetyl-beta-D-glucosaminyl-(1->3)-beta-D-galactosyl-(1->4)-beta-D-glucosyl-(1<->1)-ceramide beta-1,4-galactosyltransferase;
lactotriaosylceramide beta-1,4-galactosyltransferase (incorrect)

Class

Transferases;
Glycosyltransferases;
Hexosyltransferases

Sysname

UDP-alpha-D-galactose:N-acetyl-beta-D-glucosaminyl-(1->3)-beta-D-galactosyl-(1->4)-beta-D-glucosyl-(1<->1)-ceramide 4-beta-D-galactosyltransferase

Reaction(IUBMB)

UDP-alpha-D-galactose + N-acetyl-beta-D-glucosaminyl-(1->3)-beta-D-galactosyl-(1->4)-beta-D-glucosyl-(1<->1)-ceramide = UDP + beta-D-galactosyl-(1->4)-N-acetyl-beta-D-glucosaminyl-(1->3)-beta-D-galactosyl-(1->4)-beta-D-glucosyl-(1<->1)-ceramide [RN:R05977 R09755]

Reaction(KEGG)

R05977(G) R09755

Substrate

UDP-alpha-D-galactose [CPD:C00052];
N-acetyl-beta-D-glucosaminyl-(1->3)-beta-D-galactosyl-(1->4)-beta-D-glucosyl-(1<->1)-ceramide [CPD:C04845]

Product

UDP [CPD:C00015];
beta-D-galactosyl-(1->4)-N-acetyl-beta-D-glucosaminyl-(1->3)-beta-D-galactosyl-(1->4)-beta-D-glucosyl-(1<->1)-ceramide [CPD:C04922]

History

EC 2.4.1.275 created 2011, modified 2013

Pathway

ec00601

Glycosphingolipid biosynthesis - lacto and neolacto series

ec01100

Metabolic pathways

Orthology

K07969

beta-1,4-galactosyltransferase 4

Genes

HSA:	8702(B4GALT4)

PTR:	100608173(B4GALT4)

PPS:	100994562(B4GALT4)

GGO:	101146705(B4GALT4)

PON:	100443591(B4GALT4)

PPYG:

129033785(B4GALT4)

NLE:	100600025(B4GALT4)

HMH:	116466914(B4GALT4)

SSYN:

129471285(B4GALT4)

MCC:	711983(B4GALT4)

MCF:	102142820(B4GALT4)

MTHB:

126947755

MNI:	105470345(B4GALT4)

CSAB:

103228234(B4GALT4)

CATY:

105589723(B4GALT4)

PANU:

101019227(B4GALT4)

TGE:	112618410(B4GALT4)

MLEU:

105544630(B4GALT4)

RRO:	104657610(B4GALT4)

RBB:	108531771(B4GALT4)

TFN:	117083477(B4GALT4)

PTEH:

111543736(B4GALT4)

CANG:

105510722(B4GALT4)

CJC:	100402903(B4GALT4)

SBQ:	101029385(B4GALT4)

CIMI:

108296461(B4GALT4)

ANAN:

105725034(B4GALT4)

CSYR:

103257478(B4GALT4)

MMUR:

105879930(B4GALT4)

LCAT:

123630518(B4GALT4)

PCOQ:

105808837(B4GALT4)

OGA:	100965108(B4GALT4)

MMU:	56375(B4galt4)

MCAL:

110311536(B4galt4)

MPAH:

110329539(B4galt4)

RNO:	303923(B4galt4)

MCOC:

116085906(B4galt4)

ANU:	117718186(B4galt4)

MUN:	110555392(B4galt4)

CGE:	100689435(B4galt4)

MAUA:

101840266(B4galt4)

PROB:

127227166(B4galt4)

PLEU:

114701494(B4galt4)

MORG:

121461767(B4galt4)

MFOT:

126505726

AAMP:

119824226(B4galt4)

NGI:	103741937(B4galt4)

HGL:	101723638(B4galt4)

CPOC:

100735550(B4galt4)

CCAN:

109694543(B4galt4)

DORD:

105987926(B4galt4)

DSP:	122097753(B4galt4)

PLOP:

125351722(B4galt4)

NCAR:

124993410

MMMA:

107136294(B4galt4)

OCU:

100357504

OPI:	101535740(B4GALT4)

TUP:	102470291(B4GALT4)

GVR:	103598136(B4GALT4)

CFA:	608143(B4GALT4)

CLUD:

112677857(B4GALT4)

VVP:	112913456(B4GALT4)

VLG:	121471564(B4GALT4)

NPO:	129503953(B4GALT4)

AML:	100481658(B4GALT4)

UMR:	103678795(B4GALT4)

UAH:	113251830(B4GALT4)

UAR:	123784036(B4GALT4)

ELK:

111150160

LLV:

125097716

MPUF:

101682220(B4GALT4)

MNP:	132012207(B4GALT4)

MLK:	131825095(B4GALT4)

NVS:	122908528(B4GALT4)

ORO:	101385802(B4GALT4)

EJU:	114214700(B4GALT4)

ZCA:	113917141(B4GALT4)

MLX:	118007075(B4GALT4)

NSU:	110582414(B4GALT4)

LWW:	102743563(B4GALT4)

FCA:	101100325(B4GALT4)

PYU:	121026811 121026814

PCOO:

112850255(B4GALT4)

PBG:	122491467(B4GALT4)

PVIV:

125175407(B4GALT4)

LRUF:

124526974

PTG:	102966539(B4GALT4)

PPAD:

109266428(B4GALT4)

PUC:

125920984

AJU:

106980243

HHV:	120223122(B4GALT4)

BTA:	511328(B4GALT4)

BOM:	102279871(B4GALT4)

BIU:	109576562(B4GALT4)

BBUB:

102407421(B4GALT4)

BBIS:

104992470(B4GALT4)

CHX:	102190262(B4GALT4)

OAS:	101104949(B4GALT4)

BTAX:

128050393(B4GALT4)

CSUM:

138083242(B4GALT4)

ODA:	120871334(B4GALT4)

CCAD:

122445575(B4GALT4)

MREE:

136173449(B4GALT4)

MBEZ:

129560034(B4GALT4)

CFR:	102522848(B4GALT4)

CBAI:

105081587(B4GALT4)

CDK:	105090333(B4GALT4)

VPC:	102543992(B4GALT4)

BACU:

103005928(B4GALT4)

BMUS:

118885912 118894289(B4GALT4)

LVE:	103084555(B4GALT4)

OOR:	101278923(B4GALT4)

DLE:	111166843(B4GALT4)

PCAD:

102977710(B4GALT4)

PSIU:

116753398(B4GALT4)

NASI:

112414210(B4GALT4)

ECB:	100071082(B4GALT4)

EPZ:	103547412(B4GALT4)

EAI:	106823399(B4GALT4) 106840352

MYB:	102243483(B4GALT4)

MYD:	102775104(B4GALT4)

MMYO:

118677233(B4GALT4)

MLF:	102424615(B4GALT4)

MDT:	132230391(B4GALT4)

PKL:	118723891(B4GALT4)

EFUS:

103290708(B4GALT4)

MNA:	107527210(B4GALT4)

DRO:	112320685(B4GALT4)

SHON:

118986581(B4GALT4)

AJM:	119059204(B4GALT4)

PDIC:

114491006(B4GALT4)

PHAS:

123826745(B4GALT4)

MMF:	118617345(B4GALT4)

PPAM:

129069631(B4GALT4)

HAI:	109386911(B4GALT4)

RFQ:	117012959(B4GALT4)

PALE:

102879802(B4GALT4)

PGIG:

120586651(B4GALT4)

PVP:	105302719(B4GALT4)

RAY:	107508361(B4GALT4)

MJV:	108408457(B4GALT4)

TOD:	119257499(B4GALT4)

SARA:

101538619(B4GALT4)

SETR:

126026217(B4GALT4)

LAV:	100662008(B4GALT4)

TMU:

101352100

ETF:	101662346(B4GALT4)

DNM:	101427468(B4GALT4)

MDO:	100015888(B4GALT4)

GAS:	123239480(B4GALT4)

SHR:	100933479(B4GALT4)

AFZ:

127554104

PCW:	110208058(B4GALT4)

TVP:	118839848(B4GALT4)

PBRV:

138147453(B4GALT4)

OAA:	114817430(B4GALT4)

GGA:	418341(B4GALT4)

PCOC:

116242431(B4GALT4)

MGP:	100547867(B4GALT4)

CJO:	107320407(B4GALT4)

TPAI:

128091583(B4GALT4)

LMUT:

125688131(B4GALT4)

NMEL:

110399397(B4GALT4)

APLA:

101792176(B4GALT4)

ACYG:

106037583(B4GALT4)

CATA:

118245195(B4GALT4)

AFUL:

116496664(B4GALT4)

TGU:	100230291(B4GALT4)

LSR:	110480885(B4GALT4)

SCAN:

103827100(B4GALT4)

PMOA:

120506431(B4GALT4)

OTC:	121339348(B4GALT4)

PRUF:

121351674(B4GALT4)

GFR:	102034782(B4GALT4)

FAB:	101809954(B4GALT4)

OMA:	130248786(B4GALT4)

PHI:	102108146(B4GALT4)

PMAJ:

107205999(B4GALT4)

CCAE:

111939072(B4GALT4)

CCW:	104687053(B4GALT4)

CBRC:

103613891(B4GALT4)

ACOE:

138113000(B4GALT4)

ETL:	114055096(B4GALT4)

ZAB:	102070358(B4GALT4)

ZLE:	135452331(B4GALT4)

ACHL:

103806959(B4GALT4)

SVG:	106861701(B4GALT4)

MMEA:

130582236(B4GALT4)

HRT:	120749274(B4GALT4)

SATI:

136375463(B4GALT4)

FPG:	101915659(B4GALT4)

FCH:	102051115(B4GALT4)

CCRI:

104165245(B4GALT4)

NNT:	104412010(B4GALT4)

SHAB:

115601472(B4GALT4)

ACUN:

113483816(B4GALT4)

TALA:

104365156(B4GALT4)

ACHC:

115343602(B4GALT4)

HALD:

104325247(B4GALT4)

HLE:	104831696(B4GALT4)

AGEN:

126048934

HHAR:

128144750(B4GALT4)

GCL:

127016354

CSTI:

104557932(B4GALT4)

LDI:	104344499(B4GALT4)

MNB:

103777280

DPUB:

104298665(B4GALT4)

PPUS:

135175338(B4GALT4)

AVIT:

104278920(B4GALT4)

BRHI:

104497986(B4GALT4)

EGZ:	104126497(B4GALT4)

NNI:	104008639(B4GALT4)

PCRI:

104027586(B4GALT4)

PCAO:

104053136(B4GALT4)

PADL:

103921433(B4GALT4)

AFOR:

103894987(B4GALT4)

FGA:	104074553(B4GALT4)

GSTE:

104259789(B4GALT4)

CLV:	102093764(B4GALT4)

MUI:	104545693(B4GALT4)

PGUU:

104458150(B4GALT4)

PLET:

104616698(B4GALT4)

EHS:	104515315(B4GALT4)

CMAC:

104485873(B4GALT4)

CUCA:

104055805(B4GALT4)

TEO:	104370239(B4GALT4)

BREG:

104634611(B4GALT4)

OHA:	104328249(B4GALT4)

ACAR:

104528881(B4GALT4)

CPEA:

104389259(B4GALT4)

CVF:	104281854(B4GALT4)

RTD:	128908089(B4GALT4)

AAM:	106490705(B4GALT4)

AROW:

112960462(B4GALT4)

NPD:	112951788(B4GALT4)

TGT:	104566934(B4GALT4)

DNE:	112989408(B4GALT4)

SCAM:

104144280(B4GALT4)

ASN:	102370808(B4GALT4)

AMJ:	102569919(B4GALT4)

CPOO:

109319251(B4GALT4)

GGN:	109304505(B4GALT4)

PSS:	102453780(B4GALT4)

CMY:	102946330(B4GALT4)

CCAY:

125621393(B4GALT4)

DCC:	119852571(B4GALT4)

CPIC:

101953425(B4GALT4)

TST:	117886849(B4GALT4)

CABI:

116825981

MRV:	120400130(B4GALT4)

ACS:	100553568(b4galt4)

ASAO:

132772081(B4GALT4)

PVT:	110074021(B4GALT4)

SUND:

121925377(B4GALT4)

PBI:	103068176(B4GALT4)

PMUR:

107287653(B4GALT4)

CTIG:

120300789(B4GALT4)

TSR:	106549008(B4GALT4)

PGUT:

117662153(B4GALT4)

APRI:

131199571(B4GALT4)

PTEX:

113441668(B4GALT4)

NSS:	113421481(B4GALT4)

VKO:	123029121(B4GALT4)

PMUA:

114595809(B4GALT4)

PRAF:

128412744(B4GALT4)

ZVI:	118085493(B4GALT4)

HCG:	128352179(B4GALT4)

GJA:	107106045(B4GALT4)

STOW:

125430629(B4GALT4)

EMC:	129325976(B4GALT4)

XLA:	108707823(b4galt4.L) 444709(b4galt4.S)

XTR:	100488464(b4galt4)

NPR:	108797173(B4GALT4)

RTEM:

120928030(B4GALT4)

BBUF:

120994392(B4GALT4)

BGAR:

122930604(B4GALT4)

MUO:	115470620(B4GALT4)

GSH:	117359951(B4GALT4)

DRE:	492760(b4galt4)

SRX:	107719754 107752248(b4galt4)

SANH:

107662077 107702948

SGH:	107557767(b4galt4) 107576632

CCAR:

109059855 109105806

CAUA:

113086208 113094244

CGIB:

127958879 127991291

PTET:

122324890(b4galt4)

LROH:

127165952(b4galt4)

OMC:	131540386(b4galt4)

PPRM:

120472161(b4galt4)

RKG:	130082523(b4galt4)

MAMB:

125267779(b4galt4)

CIDE:

127512966

CERY:

137034665(b4galt4)

MASI:

127426252 127435954

TROS:

130550097(b4galt4) 130568376

TDW:	130420135(b4galt4)

MANU:

129441095(b4galt4)

IPU:

108260163

IFU:	128603803(b4galt4)

PHYP:

113531354(b4galt4)

SMEO:

124378852(b4galt4)

TFD:	113650901(b4galt4)

TVC:	132841028(b4galt4)

TRN:	134303162(b4galt4)

CMAO:

118814829(b4galt4)

EEE:	113587379(b4galt4)

CHAR:

105904396(b4galt4)

TRU:	101061200(b4galt4)

TFS:	130537421(b4galt4)

TNG:	GSTEN00019044G001

LCO:	104935626(b4galt4)

NCC:	104965999(b4galt4)

TBEN:

117490772(b4galt4)

CGOB:

115018943

PGEO:

117458582(b4galt4)

GACU:

117536977(b4galt4)

EMAC:

134871943(b4galt4)

ELY:	117271675(b4galt4)

EFO:	125897803(b4galt4)

PLEP:

121953054(b4galt4)

SLUC:

116064910(b4galt4)

ECRA:

117956097(b4galt4)

ESP:	116700058(b4galt4)

PFLV:

114566193(b4galt4)

GAT:	120822075(b4galt4)

PPUG:

119215836(b4galt4)

AFB:	129113568(b4galt4)

CLUM:

117743181(b4galt4)

PSWI:

130191907(b4galt4)

CANA:

137802698(b4galt4)

CVE:	137876318(b4galt4)

MSAM:

119895361(b4galt4)

SCHU:

122887908(b4galt4)

CUD:	121518801(b4galt4)

ALAT:

119031748(b4galt4)

ASTR:

137606079(b4galt4)

MZE:	101466383(b4galt4)

ONL:	100692349(b4galt4)

OAU:	116336153(b4galt4)

OLA:	101164915(b4galt4)

OML:	112142420(b4galt4)

CSAI:

133420660 133440621 133442173 133444882 133456313 133456915 133459586(b4galt4)

XMA:	102221477(b4galt4)

XCO:	114152935(b4galt4)

XHE:	116728667(b4galt4)

PRET:

103475412(b4galt4)

PFOR:

103141626(b4galt4)

PLAI:

106959946(b4galt4)

PMEI:

106911344(b4galt4)

GAF:	122844987(b4galt4)

PPRL:

129368814(b4galt4)

CVG:	107096681(b4galt4)

CTUL:

119778358(b4galt4)

GMU:	124876934(b4galt4)

NFU:	107386424(b4galt4)

KMR:	108237029(b4galt4)

ALIM:

106526137(b4galt4)

NWH:	119420190(b4galt4)

AOCE:

111587187(b4galt4)

EJA:	138196457(b4galt4)

MCEP:

125020865(b4galt4)

CSEM:

103395579

POV:	109628818(b4galt4)

SSEN:

122780202(b4galt4)

HHIP:

117774906(b4galt4)

HSP:	118122401(b4galt4)

PPLT:

128456564(b4galt4)

SMAU:

118301093(b4galt4)

LCF:

108893526

SDU:	111234517(b4galt4)

SLAL:

111666268(b4galt4)

XGL:	120802943(b4galt4)

HCQ:	109517999(b4galt4)

SSCV:

125982003(b4galt4)

SBIA:

133491369 133491770(b4galt4) 133492114 133492193

PEE:	133416413(b4galt4)

PTAO:

133467356(b4galt4)

BPEC:

110158487(b4galt4)

MALB:

109959384(b4galt4)

BSPL:

114869417(b4galt4)

SJO:	128371518(b4galt4)

SASA:

106563608(b4galt4) 106603047

STRU:

115154807 115204411

OTW:	112228922 112231206

OMY:	110510090(b4galt4) 110534104

OGO:	124006477 124007296(b4galt4)

ONE:	115116498 115135528

OKI:	109873181 109874262(b4galt4)

OKE:	118385022(b4galt4) 118390473

SALP:

111950662 111964307(b4galt4)

SNH:	120021475 120057301

CCLU:

121541939(b4galt4) 121579577

ELS:	105010876(b4galt4)

SFM:	108924680(b4galt4)

PKI:	111838050(b4galt4)

AANG:

118235907(b4galt4)

LOC:	102693001(b4galt4)

PSPA:

121302655 121321209

ARUT:

117405908 117972656

PSEX:

120523099(b4galt4)

LCM:	102355454 102358769

CMK:	103185094(b4galt4)

RTP:	109921819(b4galt4)

CPLA:

122555032(b4galt4)

HOC:	132821014(b4galt4)

LERI:

129702618(b4galt4)

PMRN:

116955899

CIN:

100182391

PCLA:

123763735 138365864 138365865

CQD:

128701344

TCF:

131888569

GAE:

121388902

HRF:

124121890

HRJ:	124258766 124269138 124269671

HASI:

137277192

CANU:

128159955 128173497 128180868

MMER:

123562190

RPHI:

132731522

MAEA:

128207659 128208531 128209850 128212043

» show all

Reference

1 [PMID:9792633]

Authors

Schwientek T, Almeida R, Levery SB, Holmes EH, Bennett E, Clausen H

Title

Cloning of a novel member of the UDP-galactose:beta-N-acetylglucosamine beta1,4-galactosyltransferase family, beta4Gal-T4, involved in glycosphingolipid biosynthesis.

Journal

J Biol Chem 273:29331-40 (1998)
DOI:10.1074/jbc.273.45.29331

Sequence

[hsa:8702]

Other DBs

ExplorEnz - The Enzyme Database:

2.4.1.275

IUBMB Enzyme Nomenclature:

2.4.1.275

ExPASy - ENZYME nomenclature database:

2.4.1.275

BRENDA, the Enzyme Database:

2.4.1.275

LinkDB

DBGET integrated database retrieval system