KEGG ENZYME: 2.1.1.369

ENZYME: 2.1.1.369

Entry

EC 2.1.1.369                Enzyme

Name

[histone H3]-lysine27 N-methyltransferase;
ATXR5 (gene name)

Class

Transferases;
Transferring one-carbon groups;
Methyltransferases

Sysname

S-adenosyl-L-methionine:[histone H3]-L-lysine27 N6-methyltransferase

Reaction(IUBMB)

S-adenosyl-L-methionine + a [histone H3]-L-lysine27 = S-adenosyl-L-homocysteine + a [histone H3]-N6-methyl-L-lysine27

Reaction(KEGG)

(other) R03875

Substrate

S-adenosyl-L-methionine [CPD:C00019];
[histone H3]-L-lysine27

Product

S-adenosyl-L-homocysteine [CPD:C00021];
[histone H3]-N6-methyl-L-lysine27

Comment

This entry describes enzymes that methylate the L-lysine-27 residue of histone H3 only once, generating a monomethylated form. This modification influences the binding of chromatin-associated proteins. The methylation of lysine-27 leads to transcriptional repression of the affected target genes. cf. EC 2.1.1.371, [histone H3]-lysine27 N-dimethyltransferase, and EC 2.1.1.356, [histone H3]-lysine27 N-trimethyltransferase.

History

EC 2.1.1.369 created 2020

Pathway

ec00310

Lysine degradation

ec01100

Metabolic pathways

Orthology

K24406

[histone H3]-lysine27 N-methyltransferase

Genes

ATH:	AT5G09790(ATXR5) AT5G24330(ATXR6)

ALY:	9309491 9310257

CRB:	17882998 17884103

CSAT:

104706745 104708138 104734978 104736453 104769169 104770824

EUS:	EUTSA_v10004504mg EUTSA_v10013971mg

BRP:	103847232 103874302

BNA:	106352000 106414923 106419068 106440400

BOE:	106305738 106319327

RSZ:	108815044 108852085

THJ:	104803335 104819316

CPAP:

110816170

CIT:	102609159 102609318

CIC:	CICLE_v10020975mg CICLE_v10025879mg

PVY:	116122859 116131807

MINC:

123202344 123212838

TCC:	18605807 18611813

GRA:	105788091 105788702

GHI:	107890788 107913598 107950196 121215518

GAB:	108471168 108481935

HSYR:

120162964 120206897 120207785

DZI:	111290586 111293048

EGR:	104415871 104437619

GMX:	100775247 100785817 100791762

GSJ:	114385475 114395530 114410106

PVU:	137822681 137826637

VRA:	106758877 106779733

VAR:	108328313 108330963

VUN:	114162816 114185055

VUM:

124825370

CCAJ:

109789135 109812431

APRC:

113852974 113870133 113870146

MTR:	11425543 11425658

TPRA:

123902920 123914996 123916291

CAM:	101507618 101514911

PSAT:

127079465 127091922

VVO:	131600405 131655515

LJA:

130734390

ADU:	107470399 107495147

AIP:	107620985 107648474

AHF:	112715892 112755371 112755526 112784661

LANG:

109340713 109343411

PCIN:

129294753 129308276

QSA:	O6P43_014972 O6P43_019961 O6P43_023354 O6P43_030353

FVE:	101303561 101315097

AANS:

126794819 126801855

RCN:	112182755 112189128

PPER:

18787154

PMUM:

103333608

PAVI:

110749561

PDUL:

117618836

MDM:	103407840 103443933 103454199

MSYL:

126603303 126616795 126624750

PXB:	103933959 103943391

ZJU:

107421822

MNT:	21395092 21403617

CSAV:

115716825

CSV:	101205046 101221402

CMO:	103482982 103499650

BHJ:	120067963 120087712

MCHA:

111009360 111013416

CMAX:

111470402 111471537

CMOS:

111430195 111438342 111459438

CPEP:

111777127 111785341 111794611 111809026

RCU:	8259125 8275573

MEAN:

126654064 126654462

JCU:

105645164

HBR:	110648078 110650981 110668037

MESC:

110621573 110627877 110629362

POP:	18099012 7464288 7464531 7485065

PEU:	105124608 105125904 105131195 105139778

PALZ:

118032130 118033714 118040353 118057108

PNZ:	133672322 133676250 133678926 133693121

JRE:	108990487 108994017

CILL:

122303461 122309280

CAVE:

132166547 132167302

AGLU:

133856669 133861986

QSU:	112008849 112038577

QLO:	115960479 115993965

TWL:	119986021 120004550

VVI:	100247284 100250306

VRI:	117913590 117933458

SLY:	101244542 101265411

SPEN:

107003477 107012768

SOT:	102584749 102592920

SSTN:

125844389 125859547

SDUL:

129895301 129900988

CANN:

107851724 107866114

LBB:	132614972 132632114

NTA:	107765939 107770913 107780267 107784926 107788325

NSY:	104228166 104233385

NTO:	104093644 104102104 104109469

NAU:	109214519 109218226

INI:	109146583 109183447 109189223

ITR:	115999973 116014199 116019143

SIND:

105160321 105178107

OEU:	111367804 111393831 111405651

EGT:	105965740 105965750 105971700 105973257

SSPL:

121747474 121750933 121778600 121780604

SMIL:

131008653 131014716

SHIS:

125212412 125213499

APAN:

127248918 127259666 127266475 127266476

HAN:	110903738 110935904

ECAD:

122596492 122605726

LSV:	111888890 111909687

CCAV:

112499883 112525579

DCR:

108225469

CSIN:

114257079 114285345

RVL:	131303803 131319831

AEW:	130759857 130777951 130781629

BVG:	104888202 104895443

SOE:	110783040 110791384

CQI:	110682019 110695182 110725520 110738847

ATRI:

130802239 130821252 130825036

MOF:	131145652 131165799

NNU:	104590330 104594264

MING:

122062406 122074624 122093516

TSS:	122652115 122659036 122670125

PSOM:

113293160

OSA:	107276232 4324466

OBR:	102712144 102713966

OGL:	127762869 127775364

BDI:	100822033 100834709

ATS:	109752345 109778069

TDC:	119270652 119280280 119314458 119326748 119339257 119343748 119343749 119343871 119343872 119366085

TAES:

123057322 123059561 123066908 123075866 123130185 123133523 123140971

TUA:	125513734 125546239 125547326

LPER:

127308655 127346034

LRD:	124662111 124662231 124686076 124689331

SBI:	8055044 8077421 8082070

ZMA:	100857061 103626550

MFLO:

136454094 136459976 136470851 136470971 136480957 136480959 136480963 136483923 136483926

SITA:

101774352 101783142

SVS:	117848888 117854501

PVIR:

120645463 120654492 120673839 120706092 120709343

PHAI:

112880216 112894284 112903504

PAUA:

133909669 133917350 133922790 133929319

PDA:	103695768 103703153 103714298

EGU:	105038322 105052055 105054615

MUS:	103983235 135615400

ZOF:	121971116 121999225 122004165 122011553 122014671 122017884 122029518 122049578

DCT:	110100023 110102586 110107042

PEQ:

110025867

AOF:	109822666 109824136

MSIN:

131234779 131248546

ACAK:

137934579 137948525 137959278

NCOL:

116247550 116248542

ATR:

18447687

CJF:	131038089 131060765 131075799

SMO:	SELMODRAFT_171548

PPP:

112276717

» show all

Reference

1 [PMID:19503079]

Authors

Jacob Y, Feng S, LeBlanc CA, Bernatavichute YV, Stroud H, Cokus S, Johnson LM, Pellegrini M, Jacobsen SE, Michaels SD

Title

ATXR5 and ATXR6 are H3K27 monomethyltransferases required for chromatin structure and gene silencing.

Journal

Nat Struct Mol Biol 16:763-8 (2009)
DOI:10.1038/nsmb.1611

Other DBs

ExplorEnz - The Enzyme Database:

2.1.1.369

IUBMB Enzyme Nomenclature:

2.1.1.369

ExPASy - ENZYME nomenclature database:

2.1.1.369

BRENDA, the Enzyme Database:

2.1.1.369

LinkDB

DBGET integrated database retrieval system