Entry
Name
succinate-semialdehyde dehydrogenase (NAD+);
succinate semialdehyde dehydrogenase (NAD+);
succinic semialdehyde dehydrogenase (NAD+);
succinyl semialdehyde dehydrogenase (NAD+);
succinate semialdehyde:NAD+ oxidoreductase
Class
Oxidoreductases;
Acting on the aldehyde or oxo group of donors;
With NAD+ or NADP+ as acceptor
BRITE hierarchy
Sysname
succinate-semialdehyde:NAD+ oxidoreductase
Reaction(IUBMB)
succinate semialdehyde + NAD+ + H2O = succinate + NADH + 2 H+ [RN:
R00713 ]
Reaction(KEGG)
Substrate
Product
Comment
This enzyme participates in the degradation of glutamate and 4-aminobutyrate. It is similar to EC
1.2.1.79 [succinate-semialdehyde dehydrogenase (NADP+)], and EC
1.2.1.16 [succinate-semialdehyde dehydrogenase (NAD(P)+)], but is specific for NAD+.
History
EC 1.2.1.24 created 1972, modified 2010
Pathway
ec00250 Alanine, aspartate and glutamate metabolism
ec00760 Nicotinate and nicotinamide metabolism
Orthology
K00139 succinate-semialdehyde dehydrogenase
K08324 succinate-semialdehyde dehydrogenase
K17761 succinate-semialdehyde dehydrogenase, mitochondrial
Genes
CCAN : 109688344 109688360
TVP : 118840069 118848230(ALDH5A1)
XLA : 108719155(aldh5a1.L) 108720127(aldh5a1.S)
SANH : 107700704 107704994
CAUA : 113059472 113059752 113115980
CGIB : 127974982 128030479
PTET : 122335404 122359863
ONL : 100695178 102082621 109204270
PPLT : 128449035(aldh5a1) 128449036
LCF : 108881854(aldh5a1) 108892704
OGO : 123997800(aldh5a1) 124005858
SALP : 111958654 111965042
CCLU : 121570018 123484458
SCLV : 120340859 120345548
SPU : 115919140 115929154 584281 588907
AJC : 117107856 117107857 117124148
DSI : Dsimw501_GD18186(Dsim_GD18186)
MSEX : 115444032 119189806
BTAB : 109039045 109042090 109043493
HVI : 124366992 124368749 124372999 124373370
MQU : 128998201 129002293 129002519 129002931 129002968
BROR : 134541484 134541596
AFRA : 136035561 136040782
PCHN : 125028901 125033497
PMOO : 119574106 119577885
HAME : 121858314 121879299
PCLA : 123765840(Ssadh) 123767979
PTRU : 123517118 123518212
MNZ : 135196914 135196915 135222970
MRJ : 136841665 136847863(Ssadh)
PPOI : 119089621 119091735 119092419
CEL : CELE_F45H10.1(alh-7)
CBR : CBG_20774(Cbr-alh-7)
NAI : NECAME_17234 NECAME_17858
BMY : BM_BM4124(Bma-alh-7)
PVUL : 126827545 126832436
HRF : 124151792 124151795 124151804
HASI : 137296874 137296875
CANU : 128160401 128163782
MCAF : 127716722 127720938 127736662
DPOL : 127831563 127877343
MAEA : 128216160 128216170 128217120
SHX : MS3_00007135(ALDH5A1_1) MS3_00010216(ALDH5A1_2)
LLON : 135488358 135490978 135490979
MCAZ : 138056595 138056602
CSAT : 104703296 104714237 104752380
MINC : 123197851 123225067 123226018
HSYR : 120160253 120219413
GMX : 100793318(ALDH5F1) 100808318(ALDH5F2)
LANG : 109334436 109347982
QSA : O6P43_001263 O6P43_029407
MSYL : 126586614 126624306
PXB : 103932285 103932632 103953316
CSAV : 115705451 115705619
CMAX : 111483779 111499731
CMOS : 111448470 111451231
CPEP : 111776744 111796065
VVI : 100251993 100257122 100262240
VRI : 117909618 117909619 117909620
SSPL : 121742361 121745306
APAN : 127247804 127249620
HAN : 110867957 110890180 110890181 110890182 110893559 110899848
DCR : 108192326 108200251 108205125
PSOM : 113301351 113310391 113321851 113356511
TAES : 123132549 123136622 123144134
MFLO : 136462788 136475815 136475878
PVIR : 120654790 120667033
SMO : SELMODRAFT_230009 SELMODRAFT_94736
TATV : 25782970(TrAtP1_011586) 25784554(TrAtP1_007569)
ECOO : ECRM13514_1865(yneI)
ECOH : ECRM13516_1891(yneI)
EDJ : ECDH1ME8569_1468(sad)
REE : electrica_02476(sad)
RTG : NCTC13098_03546(sad_1)
CLAP : NCTC11466_02308(sad)
KIE : NCTC12125_01278(sad_1)
AHN : NCTC12129_02627(yneI)
PSGC : G163CM_12440(sad_1)
RAQ : Rahaq2_4729 Rahaq2_5060
RVC : J9880_20495 J9880_23315
EPI : Q3V30_09855 Q3V30_19320
PLF : PANA5342_p10326(yneI)
PVA : Pvag_pPag30001(yneI)
TPTY : NCTC11468_03203(sad)
PMUI : G4G71_11765 G4G71_13340
PPRC : PFLCHA0_c38890(yneI)
PRX : HRH33_17890 HRH33_18275
PMUD : NCTC8068_03480(yneI)
PFW : PF1751_v1c37170(yneI)
PDEN : F1C79_04735 F1C79_11185
NWE : SAMEA3174300_0872(sad)
NZO : SAMEA4504057_1849(sad)
NCI : NCTC10296_01983(sad)
NCZ : NCTC10294_00601(sad)
NANI : NCTC12227_01084(sad)
ECOR : SAMEA4412678_0321(sad)
PLG : NCTC10937_02714(sad)
CNA : AB433_00760 AB433_10315
LCK : HN018_02340 HN018_22970
» show all
Taxonomy
Reference
Authors
ALBERS RW, KOVAL GJ.
Title
Succinic semialdehyde dehydrogenase: purification and properties of the enzyme from monkey brain.
Journal
Reference
Authors
Ryzlak MT, Pietruszko R
Title
Human brain "high Km" aldehyde dehydrogenase: purification, characterization, and identification as NAD+ -dependent succinic semialdehyde dehydrogenase.
Journal
Reference
Authors
Busch KB, Fromm H
Title
Plant succinic semialdehyde dehydrogenase. Cloning, purification, localization in mitochondria, and regulation by adenine nucleotides.
Journal
Sequence
Other DBs
ExplorEnz - The Enzyme Database: 1.2.1.24
ExPASy - ENZYME nomenclature database: 1.2.1.24
LinkDB
All DBs