KEGG   ENZYME: 1.14.13.227
Entry
EC 1.14.13.227              Enzyme                                 
Name
propane 2-monooxygenase;
prmABCD (gene names)
Class
Oxidoreductases;
Acting on paired donors, with incorporation or reduction of molecular oxygen;
With NADH or NADPH as one donor, and incorporation of one atom of oxygen into the other donor
Sysname
propane,NADH:oxygen oxidoreductase (2-hydroxylating)
Reaction(IUBMB)
propane + NADH + H+ + O2 = propan-2-ol + NAD+ + H2O [RN:R10702]
Reaction(KEGG)
R10702
Substrate
propane [CPD:C20783];
NADH [CPD:C00004];
H+ [CPD:C00080];
O2 [CPD:C00007]
Product
propan-2-ol [CPD:C01845];
NAD+ [CPD:C00003];
H2O [CPD:C00001]
Comment
The enzyme, characterized from several bacterial strains, is a multicomponent dinuclear iron monooxygenase that includes a hydroxylase, an NADH-dependent reductase, and a coupling protein. The enzyme has several additional activities, including acetone monooxygenase (acetol-forming) and phenol 4-monooxygenase.
History
EC 1.14.13.227 created 2016
Pathway
ec00650  Butanoate metabolism
ec01100  Metabolic pathways
Orthology
K18223  propane 2-monooxygenase large subunit
K18224  propane 2-monooxygenase small subunit
Genes
GAI: IMCC3135_23930(mmoY) IMCC3135_23940(mmoX)
BCAI: K788_0003073 K788_0003075
PHS: C2L64_20505 C2L64_20515
PACP: FAZ97_27890 FAZ97_27900
CABA: SBC2_62630(prmA_2) SBC2_62650(prmC_2)
VEI: Veis_4409 Veis_4411
MPT: Mpe_A0950(prmA) Mpe_A0952(ormC)
METP: C1M51_04490 C1M51_04500
XYK: GT347_05725 GT347_05735
AZO: azo1219 azo1221
AOA: dqs_1334 dqs_1336
AZR: CJ010_07485 CJ010_07495
MAMO: A6B35_24800 A6B35_24810
MESM: EJ066_17145 EJ066_17155
MOH: IHQ72_18715 IHQ72_18725
MMEI: LRP31_28255 LRP31_28265
AAK: AA2016_6220 AA2016_6223
RJG: CCGE525_05445 CCGE525_05455
BJA: blr3677(blr3677) blr3679(blr3679)
BJU: BJ6T_61670 BJ6T_61690
BJP: RN69_29860 RN69_29870
BRA: BRADO4348 BRADO4350
BBT: BBta_3630 BBta_3632
AOL: S58_14660 S58_14680
BIC: LMTR13_17510 LMTR13_17520
BOT: CIT37_20150 CIT37_20160
BSEP: HAP48_0008250 HAP48_0008260
BQB: J4P68_0027300 J4P68_0027310
BBAN: J4G43_042520 J4G43_042530
BGK: IC762_13930 IC762_13940
BPAH: QA639_17710 QA639_17720
BXN: I3J27_35020 I3J27_35030
BOY: LQG66_13790 LQG66_13800
STAR: G3545_26545 G3545_26555
LNE: FZC33_06715 FZC33_06725
BID: Bind_3395 Bind_3397
MSL: Msil_1649 Msil_1651
MTUN: MTUNDRAET4_0144.1(prmC) MTUNDRAET4_0146.1(prmA)
PLEO: OHA_1_03553(mmoY) OHA_1_03555(mmoX)
HDI: HDIA_3874(mmoY) HDIA_3876(mmoX)
JIE: OH818_18920
PGD: Gal_01406 Gal_01408
CBAK: DA792_01180 DA792_01190
MALG: MALG_01260 MALG_01262
PABY: Ga0080574_TMP3298 Ga0080574_TMP3300
AHT: ANTHELSMS3_04149(mmoY) ANTHELSMS3_04151(mmoX)
MALU: KU6B_14980 KU6B_15000
PALX: GQA70_22650 GQA70_22660
RSP: RSP_2792 RSP_2794
RSH: Rsph17029_1506 Rsph17029_1508
RSK: RSKD131_1174 RSKD131_1176
PAMI: JCM7686_pAMI4p208 JCM7686_pAMI4p211
GFU: KM031_18825 KM031_18835
ACR: Acry_1379 Acry_1381
AMV: ACMV_14260(prmC) ACMV_14280(prmA)
AZL: AZL_c02870 AZL_c02890
ALI: AZOLI_p10730(prmC) AZOLI_p10732(prmA)
ATI: AL072_26915 AL072_26925
AZZ: DEW08_25720 DEW08_25730
AOZ: HUE56_03135 HUE56_03145
AZS: E6C72_23970 E6C72_23980
SKT: IGS68_06155 IGS68_06165
SMUC: JL100_021455 JL100_021465 JL100_032495 JL100_032505
SROE: JL101_020155 JL101_020165
BTS: Btus_1550 Btus_1552 Btus_2036
PANC: E2636_01275 E2636_01285
SAY: TPY_3182 TPY_3184
SAP: Sulac_1731 Sulac_1734
MSA: Mycsm_01477 Mycsm_01479
MPSE: MPSD_01250
MSHO: MSHO_12020
MDX: BTO20_38070
MSIM: MSIM_49440 MSIM_49470
MYW: BVC93_11575 BVC93_11585
MSM: MSMEG_1971
MSG: MSMEI_1927 MSMEI_1929
MSB: LJ00_09835 LJ00_09845
MSN: LI99_09835 LI99_09845
MSH: LI98_09835 LI98_09845
MCB: Mycch_5463 Mycch_5465
MLL: B1R94_07255 B1R94_07265
MMAG: MMAD_31800
MTY: MTOK_17290 MTOK_17310
MHEV: MHEL_18730
MGO: AFA91_29110 AFA91_29120
MCRO: MI149_22725
MTER: 4434518_02253(mmoX) 4434518_02255(mmoY)
MHIB: MHIB_39860 MHIB_39880
ASD: AS9A_2157 AS9A_2159
NFR: ERS450000_02058(mmoY) ERS450000_02060(mmoX)
RHA: RHA1_ro00441 RHA1_ro00443
ROA: Pd630_LPD04550 Pd630_LPD04552
RAV: AAT18_26335 AAT18_26345
RHW: BFN03_06840 BFN03_06850
RRZ: CS378_15775 CS378_15785
RHOD: AOT96_22160 AOT96_22170
RCR: NCTC10994_02802(mmoX) NCTC10994_02804(mmoY)
RKO: JWS14_19305 JWS14_19315
ROZ: CBI38_04455 CBI38_04465
RPSK: JWS13_25460 JWS13_25470
RHOU: KZJ41_27790 KZJ41_27800
RHOW: A4U64_24870 A4U64_24880
RHOJ: JVH1_35630 JVH1_35640
RHOS: QWW67_17000 QWW67_17010
RHOQ: QWW98_17000 QWW98_17010
RHOY: QNA09_23295 QNA09_23305
RFA: A3L23_02106(mmoY) A3L23_02108(mmoX)
RHS: A3Q41_01275(mmoX) A3Q41_01277(mmoY)
GBR: Gbro_3551 Gbro_3553
GPO: GPOL_c34280 GPOL_c34300
GOR: KTR9_3575 KTR9_3577
GTA: BCM27_18320 BCM27_18330
GRU: GCWB2_18380(mmoX) GCWB2_18390(mmoY)
GOM: D7316_05134(mmoY) D7316_05136(mmoX)
GAV: C5O27_09755 C5O27_09765
GOD: GKZ92_17365 GKZ92_17375
GAM: GII34_01545 GII34_01555
GJI: H1R19_17090 H1R19_17100
GAMI: IHQ52_21135 IHQ52_21145
GMG: NWF22_02570 NWF22_02580
SSPN: LXH13_39055 LXH13_39065
ARTY: AHiyo4_21320 AHiyo4_21340
NDK: I601_2091(mmoX) I601_2093(mmoY)
NPS: KRR39_09015 KRR39_09025
KQI: F1D05_01950 F1D05_01960
KSL: OG809_21805 OG809_21815 OG809_39430 OG809_39440
FRA: Francci3_2518 Francci3_2520
NAKA: H7F38_07135 H7F38_07145
SACG: FDZ84_37200 FDZ84_37210
AMD: AMED_4324 AMED_4326
AMN: RAM_22015 RAM_22025
AMM: AMES_4272 AMES_4274
AMZ: B737_4272 B737_4274
AMQ: AMETH_2368 AMETH_2370 AMETH_4324 AMETH_4326
AMYB: BKN51_07845 BKN51_07855
AACD: LWP59_05735 LWP59_05745 LWP59_20300 LWP59_20310
APRT: MUY14_15865 MUY14_15875
ARHD: VSH64_06515 VSH64_06525 VSH64_14835 VSH64_14845
AMOG: QRX60_35765 QRX60_35775
ACYN: ORV05_09975 ORV05_09985
ACAB: QRX50_30615 QRX50_30625 QRX50_39915 QRX50_39925
ANW: QP939_36725 QP939_36735 QP939_46575 QP939_46585
PDX: Psed_0629 Psed_0631
PSEA: WY02_19390 WY02_19400
PSEE: FRP1_23450 FRP1_23460
PSEH: XF36_22070 XF36_22080
PSEQ: AD006_02645 AD006_02655
PECQ: AD017_10460 AD017_10470
PHH: AFB00_07920 AFB00_07930
PAUT: Pdca_07470 Pdca_07490
PBRO: HOP40_04720 HOP40_04730
PPEL: H6H00_05165 H6H00_05175
PSDS: K1T35_11030 K1T35_11040
KUT: JJ691_42080 JJ691_42100
ACTY: OG774_23125 OG774_23135
RUB: GBA63_12420 GBA63_12430
BALA: DSM104299_05052(prmC_2) DSM104299_05054(prmA)
PARN: NBH00_09495 NBH00_09500 NBH00_21780 NBH00_21790
 » show all
Reference
1  [PMID:14645271]
  Authors
Kotani T, Yamamoto T, Yurimoto H, Sakai Y, Kato N
  Title
Propane monooxygenase and NAD+-dependent secondary alcohol dehydrogenase in propane metabolism by Gordonia sp. strain TY-5.
  Journal
J Bacteriol 185:7120-8 (2003)
DOI:10.1128/JB.185.24.7120-7128.2003
Reference
2  [PMID:17873074]
  Authors
Sharp JO, Sales CM, LeBlanc JC, Liu J, Wood TK, Eltis LD, Mohn WW, Alvarez-Cohen L
  Title
An inducible propane monooxygenase is responsible for N-nitrosodimethylamine degradation by Rhodococcus sp. strain RHA1.
  Journal
Appl Environ Microbiol 73:6930-8 (2007)
DOI:10.1128/AEM.01697-07
Reference
3  [PMID:21183637]
  Authors
Furuya T, Hirose S, Osanai H, Semba H, Kino K
  Title
Identification of the monooxygenase gene clusters responsible for the regioselective oxidation of phenol to hydroquinone in mycobacteria.
  Journal
Appl Environ Microbiol 77:1214-20 (2011)
DOI:10.1128/AEM.02316-10
Other DBs
ExplorEnz - The Enzyme Database: 1.14.13.227
IUBMB Enzyme Nomenclature: 1.14.13.227
ExPASy - ENZYME nomenclature database: 1.14.13.227
BRENDA, the Enzyme Database: 1.14.13.227
LinkDB

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