KEGG   ENZYME: 1.1.1.339
Entry
EC 1.1.1.339                Enzyme                                 
Name
dTDP-6-deoxy-L-talose 4-dehydrogenase (NAD+);
tll (gene name)
Class
Oxidoreductases;
Acting on the CH-OH group of donors;
With NAD+ or NADP+ as acceptor
Sysname
dTDP-6-deoxy-beta-L-talose:NAD+ 4-oxidoreductase
Reaction(IUBMB)
dTDP-6-deoxy-beta-L-talose + NAD+ = dTDP-4-dehydro-beta-L-rhamnose + NADH + H+ [RN:R10190]
Reaction(KEGG)
R10190
Substrate
dTDP-6-deoxy-beta-L-talose [CPD:C03187];
NAD+ [CPD:C00003]
Product
dTDP-4-dehydro-beta-L-rhamnose [CPD:C00688];
NADH [CPD:C00004];
H+ [CPD:C00080]
Comment
The enzyme has been characterized from the bacterium Aggregatibacter actinomycetemcomitans, in which it participates in the biosynthesis of the serotype c-specific polysaccharide antigen. Shows no activity with NADP+.
History
EC 1.1.1.339 created 2012
Pathway
ec00523  Polyketide sugar unit biosynthesis
ec00541  Biosynthesis of various nucleotide sugars
ec01100  Metabolic pathways
ec01110  Biosynthesis of secondary metabolites
Orthology
K19180  dTDP-6-deoxy-L-talose 4-dehydrogenase (NAD+)
Genes
AAT: D11S_1703
Reference
1  [PMID:10702238]
  Authors
Nakano Y, Suzuki N, Yoshida Y, Nezu T, Yamashita Y, Koga T
  Title
Thymidine diphosphate-6-deoxy-L-lyxo-4-hexulose reductase synthesizing dTDP-6-deoxy-L-talose from Actinobacillus actinomycetemcomitans.
  Journal
J Biol Chem 275:6806-12 (2000)
DOI:10.1074/jbc.275.10.6806
  Sequence
[ag:BAA28138]
Other DBs
ExplorEnz - The Enzyme Database: 1.1.1.339
IUBMB Enzyme Nomenclature: 1.1.1.339
ExPASy - ENZYME nomenclature database: 1.1.1.339
BRENDA, the Enzyme Database: 1.1.1.339
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