Bright light vision requires rapid regeneration of the photosensitive chromophore in cone photoreceptors. This study demonstrates that such...
190か月前

During the vertebrate visual cycle, all-trans-retinal is exported from photoreceptors to the adjacent RPE or Müller glia wherein 11-cis-retinal is...
5か月前

Emixustat, a retinoid-mimetic RPE65 inhibitor, was developed as a therapeutic visual cycle modulator and used for the treatment of retinopathies.
17か月前

The visual phototransduction cascade begins with a cis–trans photoisomerization of a retinylidene chromophore associated with the visual...
51か月前

Download scientific diagram | Visual cycle and A2E formation. A2E is formed from all-trans-retinal when it reacts with phosphatidylethanolamine in the...
13か月前

This study aimed to obtain the chemical profile of PPMO and assess its eye health effects through retinoid metabolic and visual cycle pathways regulation.
4か月前

Pigment regeneration is critical for the function of cone photoreceptors in bright and rapidly-changing light conditions.
90か月前

Retinosomes are intracellular lipid bodies found in the retinal pigment epithelium (RPE). They contain retinyl esters (REs) and are thought...
21か月前

In vertebrate retinal photoreceptors, photoisomerization of opsin-bound visual chromophore 11-cis-retinal to all-trans-retinal triggers...
233か月前

Interphotoreceptor retinoid-binding protein (IRBP), also known as retinol binding protein 3 (RBP3), is a lipophilic glycoprotein specifically secreted by...
5か月前