ID RRP41_THEKO Reviewed; 249 AA.
AC Q5JIR6;
DT 30-AUG-2005, integrated into UniProtKB/Swiss-Prot.
DT 15-FEB-2005, sequence version 1.
DT 27-NOV-2024, entry version 102.
DE RecName: Full=Exosome complex component Rrp41 {ECO:0000255|HAMAP-Rule:MF_00591};
DE EC=3.1.13.- {ECO:0000255|HAMAP-Rule:MF_00591};
GN Name=rrp41 {ECO:0000255|HAMAP-Rule:MF_00591}; OrderedLocusNames=TK1634;
OS Thermococcus kodakarensis (strain ATCC BAA-918 / JCM 12380 / KOD1)
OS (Pyrococcus kodakaraensis (strain KOD1)).
OC Archaea; Euryarchaeota; Thermococci; Thermococcales; Thermococcaceae;
OC Thermococcus.
OX NCBI_TaxID=69014;
RN [1]
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC STRAIN=ATCC BAA-918 / JCM 12380 / KOD1;
RX PubMed=15710748; DOI=10.1101/gr.3003105;
RA Fukui T., Atomi H., Kanai T., Matsumi R., Fujiwara S., Imanaka T.;
RT "Complete genome sequence of the hyperthermophilic archaeon Thermococcus
RT kodakaraensis KOD1 and comparison with Pyrococcus genomes.";
RL Genome Res. 15:352-363(2005).
CC -!- FUNCTION: Catalytic component of the exosome, which is a complex
CC involved in RNA degradation. Has 3'->5' exoribonuclease activity. Can
CC also synthesize heteromeric RNA-tails. {ECO:0000255|HAMAP-
CC Rule:MF_00591}.
CC -!- SUBUNIT: Component of the archaeal exosome complex. Forms a hexameric
CC ring-like arrangement composed of 3 Rrp41-Rrp42 heterodimers. The
CC hexameric ring associates with a trimer of Rrp4 and/or Csl4 subunits.
CC {ECO:0000255|HAMAP-Rule:MF_00591}.
CC -!- SUBCELLULAR LOCATION: Cytoplasm {ECO:0000255|HAMAP-Rule:MF_00591}.
CC -!- SIMILARITY: Belongs to the RNase PH family. Rrp41 subfamily.
CC {ECO:0000255|HAMAP-Rule:MF_00591}.
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DR EMBL; AP006878; BAD85823.1; -; Genomic_DNA.
DR RefSeq; WP_011250585.1; NC_006624.1.
DR AlphaFoldDB; Q5JIR6; -.
DR SMR; Q5JIR6; -.
DR STRING; 69014.TK1634; -.
DR EnsemblBacteria; BAD85823; BAD85823; TK1634.
DR GeneID; 78448162; -.
DR KEGG; tko:TK1634; -.
DR PATRIC; fig|69014.16.peg.1593; -.
DR eggNOG; arCOG01575; Archaea.
DR HOGENOM; CLU_063514_0_0_2; -.
DR InParanoid; Q5JIR6; -.
DR OrthoDB; 24266at2157; -.
DR PhylomeDB; Q5JIR6; -.
DR Proteomes; UP000000536; Chromosome.
DR GO; GO:0000177; C:cytoplasmic exosome (RNase complex); IBA:GO_Central.
DR GO; GO:0000175; F:3'-5'-RNA exonuclease activity; IEA:UniProtKB-UniRule.
DR GO; GO:0003723; F:RNA binding; IBA:GO_Central.
DR GO; GO:0016075; P:rRNA catabolic process; IBA:GO_Central.
DR CDD; cd11366; RNase_PH_archRRP41; 1.
DR FunFam; 3.30.230.70:FF:000004; Exosome complex component Rrp41; 1.
DR Gene3D; 3.30.230.70; GHMP Kinase, N-terminal domain; 1.
DR HAMAP; MF_00591; Exosome_Rrp41; 1.
DR InterPro; IPR001247; ExoRNase_PH_dom1.
DR InterPro; IPR015847; ExoRNase_PH_dom2.
DR InterPro; IPR036345; ExoRNase_PH_dom2_sf.
DR InterPro; IPR027408; PNPase/RNase_PH_dom_sf.
DR InterPro; IPR020568; Ribosomal_Su5_D2-typ_SF.
DR InterPro; IPR050080; RNase_PH.
DR InterPro; IPR011807; Rrp41.
DR NCBIfam; TIGR02065; ECX1; 1.
DR PANTHER; PTHR11953; EXOSOME COMPLEX COMPONENT; 1.
DR PANTHER; PTHR11953:SF2; EXOSOME COMPLEX COMPONENT MTR3; 1.
DR Pfam; PF01138; RNase_PH; 1.
DR Pfam; PF03725; RNase_PH_C; 1.
DR SUPFAM; SSF55666; Ribonuclease PH domain 2-like; 1.
DR SUPFAM; SSF54211; Ribosomal protein S5 domain 2-like; 1.
PE 3: Inferred from homology;
KW Cytoplasm; Exonuclease; Exosome; Hydrolase; Nuclease; Reference proteome.
FT CHAIN 1..249
FT /note="Exosome complex component Rrp41"
FT /id="PRO_0000139989"
SQ SEQUENCE 249 AA; 27628 MW; A745E93C6832E2CF CRC64;
MMGRPEGLKL IDENGKRIDG RKKYELRPIK MEVGVLKNAD GSAYVEWGKN KVLAAVYGPR
EIHPKHLQRP DRAILRVRYN MAPFSVEERK KPGPDRRSVE ISKVIRGALE PALLLHMFPR
TAIDVFIEIL QADAGTRVAG ITAASLALAD AGIPMKDLVA ACAAGKIDGE IVLDLNKEED
NYGEADVPVA IMPLKNDITL LQMDGYLTKD EFLEAVRLAI KGAKAVYQKQ REALKEKYLK
IAQEVEGNE
//
