ID DHQS_CENSY Reviewed; 338 AA.
AC A0RU27;
DT 05-MAY-2009, integrated into UniProtKB/Swiss-Prot.
DT 09-JAN-2007, sequence version 1.
DT 27-NOV-2024, entry version 57.
DE RecName: Full=3-dehydroquinate synthase {ECO:0000255|HAMAP-Rule:MF_01244};
DE Short=DHQ synthase {ECO:0000255|HAMAP-Rule:MF_01244};
DE EC=1.4.1.24 {ECO:0000255|HAMAP-Rule:MF_01244};
DE AltName: Full=3-dehydroquinate synthase II {ECO:0000255|HAMAP-Rule:MF_01244};
GN Name=aroB' {ECO:0000255|HAMAP-Rule:MF_01244};
GN OrderedLocusNames=CENSYa_0201;
OS Cenarchaeum symbiosum (strain A).
OC Archaea; Nitrososphaerota; Candidatus Cenarchaeales;
OC Candidatus Cenarchaeaceae; Candidatus Cenarchaeum.
OX NCBI_TaxID=414004;
RN [1]
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC STRAIN=A;
RX PubMed=17114289; DOI=10.1073/pnas.0608549103;
RA Hallam S.J., Konstantinidis K.T., Putnam N., Schleper C., Watanabe Y.,
RA Sugahara J., Preston C., de la Torre J., Richardson P.M., DeLong E.F.;
RT "Genomic analysis of the uncultivated marine crenarchaeote Cenarchaeum
RT symbiosum.";
RL Proc. Natl. Acad. Sci. U.S.A. 103:18296-18301(2006).
CC -!- FUNCTION: Catalyzes the oxidative deamination and cyclization of 2-
CC amino-3,7-dideoxy-D-threo-hept-6-ulosonic acid (ADH) to yield 3-
CC dehydroquinate (DHQ), which is fed into the canonical shikimic pathway
CC of aromatic amino acid biosynthesis. {ECO:0000255|HAMAP-Rule:MF_01244}.
CC -!- CATALYTIC ACTIVITY:
CC Reaction=2-amino-2,3,7-trideoxy-D-lyxo-hept-6-ulosonate + NAD(+) + H2O
CC = 3-dehydroquinate + NH4(+) + NADH + H(+); Xref=Rhea:RHEA:25956,
CC ChEBI:CHEBI:15377, ChEBI:CHEBI:15378, ChEBI:CHEBI:28938,
CC ChEBI:CHEBI:32364, ChEBI:CHEBI:57540, ChEBI:CHEBI:57945,
CC ChEBI:CHEBI:58859; EC=1.4.1.24; Evidence={ECO:0000255|HAMAP-
CC Rule:MF_01244};
CC -!- SIMILARITY: Belongs to the archaeal-type DHQ synthase family.
CC {ECO:0000255|HAMAP-Rule:MF_01244}.
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DR EMBL; DP000238; ABK76844.1; -; Genomic_DNA.
DR AlphaFoldDB; A0RU27; -.
DR STRING; 414004.CENSYa_0201; -.
DR EnsemblBacteria; ABK76844; ABK76844; CENSYa_0201.
DR KEGG; csy:CENSYa_0201; -.
DR PATRIC; fig|414004.10.peg.176; -.
DR HOGENOM; CLU_056379_0_0_2; -.
DR Proteomes; UP000000758; Chromosome.
DR GO; GO:0003856; F:3-dehydroquinate synthase activity; IEA:InterPro.
DR GO; GO:0102042; F:dehydroquinate synthase activity; IEA:UniProtKB-EC.
DR GO; GO:0051287; F:NAD binding; IEA:UniProtKB-UniRule.
DR GO; GO:0008652; P:amino acid biosynthetic process; IEA:UniProtKB-KW.
DR GO; GO:0009073; P:aromatic amino acid family biosynthetic process; IEA:UniProtKB-UniRule.
DR HAMAP; MF_01244; Arch_DHQ_synthase; 1.
DR InterPro; IPR002812; DHQ_synth.
DR PANTHER; PTHR33563; -; 1.
DR PANTHER; PTHR33563:SF1; 3-DEHYDROQUINATE SYNTHASE; 1.
DR Pfam; PF01959; DHQS; 1.
PE 3: Inferred from homology;
KW Amino-acid biosynthesis; Aromatic amino acid biosynthesis; NAD;
KW Oxidoreductase; Reference proteome.
FT CHAIN 1..338
FT /note="3-dehydroquinate synthase"
FT /id="PRO_0000372043"
SQ SEQUENCE 338 AA; 37043 MW; 143FF962D055DCEB CRC64;
MPRAQLQRFL SGISAEGIRT VYLDPKDAAK AKLDAMHSSP SSRYVVLEGR AAKPRGKKVG
RRFKILSNKD IDGVLQEAQK GLDFVITEVQ DWKIIPLENM IAKLHKIHTR LYAVARSPAE
VRKMFSILDV GVDGVIFTAS TVGDVREALV HLGTKSFRLQ PARITEIREV GDGERVCVDT
ASMLERGEGM LVGSRSNFMF LVHNESVGSS FTSPRPFRVN AGAVHSYTLG TDGNTLYLSE
VETGTEVLVL DSHGRARRAA VGRSKIERRP MLMIKAEADG EIGGIIAQDA ETIRFVRPGG
GLVSVTHLKK GDKVLVHSKP AAGRHFGMEV ADEYILEK
//
