ID CDC64_HALSA Reviewed; 410 AA.
AC Q9HHJ7;
DT 19-SEP-2002, integrated into UniProtKB/Swiss-Prot.
DT 01-MAR-2001, sequence version 1.
DT 27-NOV-2024, entry version 118.
DE RecName: Full=ORC1-type DNA replication protein 4 {ECO:0000255|HAMAP-Rule:MF_01407};
GN Name=orc4; OrderedLocusNames=VNG_6363G;
OS Halobacterium salinarum (strain ATCC 700922 / JCM 11081 / NRC-1)
OS (Halobacterium halobium).
OG Plasmid pNRC200.
OC Archaea; Euryarchaeota; Stenosarchaea group; Halobacteria; Halobacteriales;
OC Halobacteriaceae; Halobacterium; Halobacterium salinarum NRC-34001.
OX NCBI_TaxID=64091;
RN [1]
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC STRAIN=ATCC 700922 / JCM 11081 / NRC-1;
RX PubMed=11016950; DOI=10.1073/pnas.190337797;
RA Ng W.V., Kennedy S.P., Mahairas G.G., Berquist B., Pan M., Shukla H.D.,
RA Lasky S.R., Baliga N.S., Thorsson V., Sbrogna J., Swartzell S., Weir D.,
RA Hall J., Dahl T.A., Welti R., Goo Y.A., Leithauser B., Keller K., Cruz R.,
RA Danson M.J., Hough D.W., Maddocks D.G., Jablonski P.E., Krebs M.P.,
RA Angevine C.M., Dale H., Isenbarger T.A., Peck R.F., Pohlschroder M.,
RA Spudich J.L., Jung K.-H., Alam M., Freitas T., Hou S., Daniels C.J.,
RA Dennis P.P., Omer A.D., Ebhardt H., Lowe T.M., Liang P., Riley M., Hood L.,
RA DasSarma S.;
RT "Genome sequence of Halobacterium species NRC-1.";
RL Proc. Natl. Acad. Sci. U.S.A. 97:12176-12181(2000).
RN [2]
RP DISRUPTION PHENOTYPE.
RC STRAIN=ATCC 700922 / JCM 11081 / NRC-1;
RX PubMed=17559652; DOI=10.1186/1471-2156-8-31;
RA Berquist B.R., DasSarma P., DasSarma S.;
RT "Essential and non-essential DNA replication genes in the model halophilic
RT Archaeon, Halobacterium sp. NRC-1.";
RL BMC Genet. 8:31-31(2007).
CC -!- FUNCTION: Involved in regulation of DNA replication.
CC {ECO:0000255|HAMAP-Rule:MF_01407}.
CC -!- DISRUPTION PHENOTYPE: Not essential for normal growth.
CC {ECO:0000269|PubMed:17559652}.
CC -!- SIMILARITY: Belongs to the CDC6/cdc18 family. {ECO:0000255|HAMAP-
CC Rule:MF_01407}.
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DR EMBL; AE004438; AAG20983.1; -; Genomic_DNA.
DR RefSeq; WP_010904194.1; NZ_BK010831.1.
DR AlphaFoldDB; Q9HHJ7; -.
DR SMR; Q9HHJ7; -.
DR GeneID; 1449358; -.
DR KEGG; hal:VNG_6363G; -.
DR PATRIC; fig|64091.14.peg.2322; -.
DR HOGENOM; CLU_025112_2_1_2; -.
DR InParanoid; Q9HHJ7; -.
DR OrthoDB; 195574at2157; -.
DR Proteomes; UP000000554; Plasmid pNRC200.
DR GO; GO:0005524; F:ATP binding; IEA:UniProtKB-UniRule.
DR GO; GO:0016887; F:ATP hydrolysis activity; IEA:InterPro.
DR GO; GO:0006260; P:DNA replication; IEA:UniProtKB-UniRule.
DR CDD; cd08768; Cdc6_C; 1.
DR FunFam; 1.10.10.10:FF:000780; ORC1-type DNA replication protein; 1.
DR FunFam; 1.10.8.60:FF:000073; ORC1-type DNA replication protein; 1.
DR FunFam; 3.40.50.300:FF:000930; ORC1-type DNA replication protein; 1.
DR Gene3D; 1.10.8.60; -; 1.
DR Gene3D; 3.40.50.300; P-loop containing nucleotide triphosphate hydrolases; 1.
DR Gene3D; 1.10.10.10; Winged helix-like DNA-binding domain superfamily/Winged helix DNA-binding domain; 1.
DR HAMAP; MF_01407; ORC1_type_DNA_replic_protein; 1.
DR InterPro; IPR003593; AAA+_ATPase.
DR InterPro; IPR041664; AAA_16.
DR InterPro; IPR015163; Cdc6_C.
DR InterPro; IPR055237; Cdc6_lid.
DR InterPro; IPR050311; ORC1/CDC6.
DR InterPro; IPR014277; Orc1/Cdc6_arc.
DR InterPro; IPR027417; P-loop_NTPase.
DR InterPro; IPR036388; WH-like_DNA-bd_sf.
DR InterPro; IPR036390; WH_DNA-bd_sf.
DR NCBIfam; TIGR02928; orc1/cdc6 family replication initiation protein; 1.
DR PANTHER; PTHR10763; CELL DIVISION CONTROL PROTEIN 6-RELATED; 1.
DR PANTHER; PTHR10763:SF22; ORC1-TYPE DNA REPLICATION PROTEIN 3; 1.
DR Pfam; PF13191; AAA_16; 1.
DR Pfam; PF09079; Cdc6_C; 1.
DR Pfam; PF22703; Cdc6_lid; 1.
DR SMART; SM00382; AAA; 1.
DR SMART; SM01074; Cdc6_C; 1.
DR SUPFAM; SSF52540; P-loop containing nucleoside triphosphate hydrolases; 1.
DR SUPFAM; SSF46785; Winged helix' DNA-binding domain; 1.
PE 3: Inferred from homology;
KW ATP-binding; DNA replication; Nucleotide-binding; Plasmid;
KW Reference proteome.
FT CHAIN 1..410
FT /note="ORC1-type DNA replication protein 4"
FT /id="PRO_0000151001"
FT BINDING 73..77
FT /ligand="ATP"
FT /ligand_id="ChEBI:CHEBI:30616"
FT /evidence="ECO:0000255|HAMAP-Rule:MF_01407"
FT BINDING 220
FT /ligand="ATP"
FT /ligand_id="ChEBI:CHEBI:30616"
FT /evidence="ECO:0000255|HAMAP-Rule:MF_01407"
FT BINDING 232
FT /ligand="ATP"
FT /ligand_id="ChEBI:CHEBI:30616"
FT /evidence="ECO:0000255|HAMAP-Rule:MF_01407"
SQ SEQUENCE 410 AA; 45633 MW; 93792082797E54A9 CRC64;
MTPDSSPSSV DDPLFESGHR IFANKDLLKI GHVPEADRIV GRDEEISKLA KRLNGAVHGY
SPENVMIYGK TGTGKSLVSK HVCQRAQNAA QDGVEIGTAY IDCAEDNTET QAISSLAAKL
NDESSTGISV PHTGLSTSKY YKLLWKTLDA QFDSVIIILD EIDLMNDDSV LMKLSRAEEA
GKIDCSVGVI AISNKIQYVD NVNERVKSSF QHKELFFKPY DANQLREIMF NREDAFQDGV
LSEDVIPLSA AFAAQEHGDA RKAIDILRHA GEVAYEAGAE LVTEEHVRQA QQHAEKDRFR
ELVNGAPTQA KAALLALTEL SVNSNDDAFL TSRVYDQYEH ICNHLDMDIL SVRRFRDILK
EQAFLGVVEI EKINKGSAGG IHLQNRLIED SQVVRETILE DSRMQDWTRE
//
