ID ACPH_YERPE Reviewed; 193 AA.
AC Q8ZC31; Q0WC90; Q74WU4; Q8D165;
DT 07-MAR-2006, integrated into UniProtKB/Swiss-Prot.
DT 01-MAR-2002, sequence version 1.
DT 27-NOV-2024, entry version 111.
DE RecName: Full=Acyl carrier protein phosphodiesterase {ECO:0000255|HAMAP-Rule:MF_01950};
DE Short=ACP phosphodiesterase {ECO:0000255|HAMAP-Rule:MF_01950};
DE EC=3.1.4.14 {ECO:0000255|HAMAP-Rule:MF_01950};
GN Name=acpH {ECO:0000255|HAMAP-Rule:MF_01950};
GN OrderedLocusNames=YPO3193, y0989, YP_0738;
OS Yersinia pestis.
OC Bacteria; Pseudomonadota; Gammaproteobacteria; Enterobacterales;
OC Yersiniaceae; Yersinia.
OX NCBI_TaxID=632;
RN [1]
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC STRAIN=CO-92 / Biovar Orientalis;
RX PubMed=11586360; DOI=10.1038/35097083;
RA Parkhill J., Wren B.W., Thomson N.R., Titball R.W., Holden M.T.G.,
RA Prentice M.B., Sebaihia M., James K.D., Churcher C.M., Mungall K.L.,
RA Baker S., Basham D., Bentley S.D., Brooks K., Cerdeno-Tarraga A.-M.,
RA Chillingworth T., Cronin A., Davies R.M., Davis P., Dougan G., Feltwell T.,
RA Hamlin N., Holroyd S., Jagels K., Karlyshev A.V., Leather S., Moule S.,
RA Oyston P.C.F., Quail M.A., Rutherford K.M., Simmonds M., Skelton J.,
RA Stevens K., Whitehead S., Barrell B.G.;
RT "Genome sequence of Yersinia pestis, the causative agent of plague.";
RL Nature 413:523-527(2001).
RN [2]
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC STRAIN=KIM10+ / Biovar Mediaevalis;
RX PubMed=12142430; DOI=10.1128/jb.184.16.4601-4611.2002;
RA Deng W., Burland V., Plunkett G. III, Boutin A., Mayhew G.F., Liss P.,
RA Perna N.T., Rose D.J., Mau B., Zhou S., Schwartz D.C., Fetherston J.D.,
RA Lindler L.E., Brubaker R.R., Plano G.V., Straley S.C., McDonough K.A.,
RA Nilles M.L., Matson J.S., Blattner F.R., Perry R.D.;
RT "Genome sequence of Yersinia pestis KIM.";
RL J. Bacteriol. 184:4601-4611(2002).
RN [3]
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC STRAIN=91001 / Biovar Mediaevalis;
RX PubMed=15368893; DOI=10.1093/dnares/11.3.179;
RA Song Y., Tong Z., Wang J., Wang L., Guo Z., Han Y., Zhang J., Pei D.,
RA Zhou D., Qin H., Pang X., Han Y., Zhai J., Li M., Cui B., Qi Z., Jin L.,
RA Dai R., Chen F., Li S., Ye C., Du Z., Lin W., Wang J., Yu J., Yang H.,
RA Wang J., Huang P., Yang R.;
RT "Complete genome sequence of Yersinia pestis strain 91001, an isolate
RT avirulent to humans.";
RL DNA Res. 11:179-197(2004).
CC -!- FUNCTION: Converts holo-ACP to apo-ACP by hydrolytic cleavage of the
CC phosphopantetheine prosthetic group from ACP. {ECO:0000255|HAMAP-
CC Rule:MF_01950}.
CC -!- CATALYTIC ACTIVITY:
CC Reaction=holo-[ACP] + H2O = apo-[ACP] + (R)-4'-phosphopantetheine +
CC H(+); Xref=Rhea:RHEA:20537, Rhea:RHEA-COMP:9685, Rhea:RHEA-COMP:9690,
CC ChEBI:CHEBI:15377, ChEBI:CHEBI:15378, ChEBI:CHEBI:29999,
CC ChEBI:CHEBI:61723, ChEBI:CHEBI:64479; EC=3.1.4.14;
CC Evidence={ECO:0000255|HAMAP-Rule:MF_01950};
CC -!- SIMILARITY: Belongs to the AcpH family. {ECO:0000255|HAMAP-
CC Rule:MF_01950}.
CC -!- SEQUENCE CAUTION:
CC Sequence=AAM84570.1; Type=Erroneous initiation; Evidence={ECO:0000305};
CC Sequence=AAS61003.1; Type=Erroneous initiation; Evidence={ECO:0000305};
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DR EMBL; AL590842; CAL21788.1; -; Genomic_DNA.
DR EMBL; AE009952; AAM84570.1; ALT_INIT; Genomic_DNA.
DR EMBL; AE017042; AAS61003.1; ALT_INIT; Genomic_DNA.
DR PIR; AI0387; AI0387.
DR RefSeq; WP_002216927.1; NZ_WUCM01000079.1.
DR RefSeq; YP_002348098.1; NC_003143.1.
DR AlphaFoldDB; Q8ZC31; -.
DR STRING; 214092.YPO3193; -.
DR PaxDb; 214092-YPO3193; -.
DR DNASU; 1145936; -.
DR EnsemblBacteria; AAS61003; AAS61003; YP_0738.
DR GeneID; 66842646; -.
DR KEGG; ype:YPO3193; -.
DR KEGG; ypj:CH55_1770; -.
DR KEGG; ypk:y0989; -.
DR KEGG; ypl:CH46_1909; -.
DR KEGG; ypm:YP_0738; -.
DR KEGG; ypv:BZ15_336; -.
DR KEGG; ypw:CH59_2867; -.
DR PATRIC; fig|1028802.3.peg.403; -.
DR eggNOG; COG3124; Bacteria.
DR HOGENOM; CLU_099370_1_0_6; -.
DR OrthoDB; 8442777at2; -.
DR Proteomes; UP000000815; Chromosome.
DR Proteomes; UP000001019; Chromosome.
DR Proteomes; UP000002490; Chromosome.
DR GO; GO:0008770; F:[acyl-carrier-protein] phosphodiesterase activity; IBA:GO_Central.
DR GO; GO:0006633; P:fatty acid biosynthetic process; IBA:GO_Central.
DR HAMAP; MF_01950; AcpH; 1.
DR InterPro; IPR007431; ACP_PD.
DR InterPro; IPR023491; ACP_phosphodiesterase_gpbac.
DR PANTHER; PTHR38764; ACYL CARRIER PROTEIN PHOSPHODIESTERASE; 1.
DR PANTHER; PTHR38764:SF1; ACYL CARRIER PROTEIN PHOSPHODIESTERASE; 1.
DR Pfam; PF04336; ACP_PD; 1.
DR PIRSF; PIRSF011489; DUF479; 1.
PE 3: Inferred from homology;
KW Fatty acid biosynthesis; Fatty acid metabolism; Hydrolase;
KW Lipid biosynthesis; Lipid metabolism; Reference proteome.
FT CHAIN 1..193
FT /note="Acyl carrier protein phosphodiesterase"
FT /id="PRO_0000226278"
SQ SEQUENCE 193 AA; 22351 MW; 6921FA82A025990A CRC64;
MNFLAHLHLA ALADSSLLGN LLADFVRGNP QGEYPPEIVA GIMMHRRVDV MTDTLPLVKE
ARTYFSADYR RVSPITLDVL WDHFLARHWD QLVPNCTLPD FLQHAQSQIL PHLPHTPARF
QSLNAYLWSE RWLERYAELP FIADVLQGMA NRRPKLAALA GSFYAIEQHY QPLEDLFLTF
YPTMMRQAQH KQI
//
