ID ACPH_ECOL6 Reviewed; 193 AA.
AC Q8FKC6;
DT 07-MAR-2006, integrated into UniProtKB/Swiss-Prot.
DT 07-MAR-2006, sequence version 2.
DT 27-NOV-2024, entry version 91.
DE RecName: Full=Acyl carrier protein phosphodiesterase {ECO:0000255|HAMAP-Rule:MF_01950};
DE Short=ACP phosphodiesterase {ECO:0000255|HAMAP-Rule:MF_01950};
DE EC=3.1.4.14 {ECO:0000255|HAMAP-Rule:MF_01950};
GN Name=acpH {ECO:0000255|HAMAP-Rule:MF_01950}; OrderedLocusNames=c0514;
OS Escherichia coli O6:H1 (strain CFT073 / ATCC 700928 / UPEC).
OC Bacteria; Pseudomonadota; Gammaproteobacteria; Enterobacterales;
OC Enterobacteriaceae; Escherichia.
OX NCBI_TaxID=199310;
RN [1]
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC STRAIN=CFT073 / ATCC 700928 / UPEC;
RX PubMed=12471157; DOI=10.1073/pnas.252529799;
RA Welch R.A., Burland V., Plunkett G. III, Redford P., Roesch P., Rasko D.,
RA Buckles E.L., Liou S.-R., Boutin A., Hackett J., Stroud D., Mayhew G.F.,
RA Rose D.J., Zhou S., Schwartz D.C., Perna N.T., Mobley H.L.T.,
RA Donnenberg M.S., Blattner F.R.;
RT "Extensive mosaic structure revealed by the complete genome sequence of
RT uropathogenic Escherichia coli.";
RL Proc. Natl. Acad. Sci. U.S.A. 99:17020-17024(2002).
CC -!- FUNCTION: Converts holo-ACP to apo-ACP by hydrolytic cleavage of the
CC phosphopantetheine prosthetic group from ACP. {ECO:0000255|HAMAP-
CC Rule:MF_01950}.
CC -!- CATALYTIC ACTIVITY:
CC Reaction=holo-[ACP] + H2O = apo-[ACP] + (R)-4'-phosphopantetheine +
CC H(+); Xref=Rhea:RHEA:20537, Rhea:RHEA-COMP:9685, Rhea:RHEA-COMP:9690,
CC ChEBI:CHEBI:15377, ChEBI:CHEBI:15378, ChEBI:CHEBI:29999,
CC ChEBI:CHEBI:61723, ChEBI:CHEBI:64479; EC=3.1.4.14;
CC Evidence={ECO:0000255|HAMAP-Rule:MF_01950};
CC -!- SIMILARITY: Belongs to the AcpH family. {ECO:0000255|HAMAP-
CC Rule:MF_01950}.
CC -!- SEQUENCE CAUTION:
CC Sequence=AAN78992.1; Type=Erroneous initiation; Evidence={ECO:0000305};
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DR EMBL; AE014075; AAN78992.1; ALT_INIT; Genomic_DNA.
DR RefSeq; WP_001009873.1; NZ_CP051263.1.
DR AlphaFoldDB; Q8FKC6; -.
DR SMR; Q8FKC6; -.
DR STRING; 199310.c0514; -.
DR KEGG; ecc:c0514; -.
DR eggNOG; COG3124; Bacteria.
DR HOGENOM; CLU_099370_1_0_6; -.
DR Proteomes; UP000001410; Chromosome.
DR GO; GO:0008770; F:[acyl-carrier-protein] phosphodiesterase activity; IEA:UniProtKB-UniRule.
DR GO; GO:0006633; P:fatty acid biosynthetic process; IEA:UniProtKB-UniRule.
DR HAMAP; MF_01950; AcpH; 1.
DR InterPro; IPR007431; ACP_PD.
DR InterPro; IPR023491; ACP_phosphodiesterase_gpbac.
DR PANTHER; PTHR38764; ACYL CARRIER PROTEIN PHOSPHODIESTERASE; 1.
DR PANTHER; PTHR38764:SF1; ACYL CARRIER PROTEIN PHOSPHODIESTERASE; 1.
DR Pfam; PF04336; ACP_PD; 1.
DR PIRSF; PIRSF011489; DUF479; 1.
PE 3: Inferred from homology;
KW Fatty acid biosynthesis; Fatty acid metabolism; Hydrolase;
KW Lipid biosynthesis; Lipid metabolism; Reference proteome.
FT CHAIN 1..193
FT /note="Acyl carrier protein phosphodiesterase"
FT /id="PRO_0000226267"
SQ SEQUENCE 193 AA; 23052 MW; C02716160F51E8B3 CRC64;
MNFLAHLHLA HLAESSLSGN LLADFVRGNP EESFPPDVVA GIHMHRRIDV LTDNLPEVRE
AREWFRNETR RVAPITLDVM WDHFLSRHWS QLSPDFPLQE FTCYAREQVM TILPDSPQRF
INLNNYLWSE QWLVRYRDMD FIQSVLNGMA SRRPRLDALR DSWYDLDAHY DALETRFWQF
YPRMMEQASR KAL
//