ID ACPH_ECOHS Reviewed; 193 AA.
AC A7ZX55;
DT 05-FEB-2008, integrated into UniProtKB/Swiss-Prot.
DT 23-OCT-2007, sequence version 1.
DT 27-NOV-2024, entry version 69.
DE RecName: Full=Acyl carrier protein phosphodiesterase {ECO:0000255|HAMAP-Rule:MF_01950};
DE Short=ACP phosphodiesterase {ECO:0000255|HAMAP-Rule:MF_01950};
DE EC=3.1.4.14 {ECO:0000255|HAMAP-Rule:MF_01950};
GN Name=acpH {ECO:0000255|HAMAP-Rule:MF_01950}; OrderedLocusNames=EcHS_A0474;
OS Escherichia coli O9:H4 (strain HS).
OC Bacteria; Pseudomonadota; Gammaproteobacteria; Enterobacterales;
OC Enterobacteriaceae; Escherichia.
OX NCBI_TaxID=331112;
RN [1]
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC STRAIN=HS;
RX PubMed=18676672; DOI=10.1128/jb.00619-08;
RA Rasko D.A., Rosovitz M.J., Myers G.S.A., Mongodin E.F., Fricke W.F.,
RA Gajer P., Crabtree J., Sebaihia M., Thomson N.R., Chaudhuri R.,
RA Henderson I.R., Sperandio V., Ravel J.;
RT "The pangenome structure of Escherichia coli: comparative genomic analysis
RT of E. coli commensal and pathogenic isolates.";
RL J. Bacteriol. 190:6881-6893(2008).
CC -!- FUNCTION: Converts holo-ACP to apo-ACP by hydrolytic cleavage of the
CC phosphopantetheine prosthetic group from ACP. {ECO:0000255|HAMAP-
CC Rule:MF_01950}.
CC -!- CATALYTIC ACTIVITY:
CC Reaction=holo-[ACP] + H2O = apo-[ACP] + (R)-4'-phosphopantetheine +
CC H(+); Xref=Rhea:RHEA:20537, Rhea:RHEA-COMP:9685, Rhea:RHEA-COMP:9690,
CC ChEBI:CHEBI:15377, ChEBI:CHEBI:15378, ChEBI:CHEBI:29999,
CC ChEBI:CHEBI:61723, ChEBI:CHEBI:64479; EC=3.1.4.14;
CC Evidence={ECO:0000255|HAMAP-Rule:MF_01950};
CC -!- SIMILARITY: Belongs to the AcpH family. {ECO:0000255|HAMAP-
CC Rule:MF_01950}.
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DR EMBL; CP000802; ABV04859.1; -; Genomic_DNA.
DR RefSeq; WP_001009884.1; NC_009800.1.
DR AlphaFoldDB; A7ZX55; -.
DR SMR; A7ZX55; -.
DR GeneID; 75202826; -.
DR KEGG; ecx:EcHS_A0474; -.
DR HOGENOM; CLU_099370_1_0_6; -.
DR Proteomes; UP000001123; Chromosome.
DR GO; GO:0008770; F:[acyl-carrier-protein] phosphodiesterase activity; IEA:UniProtKB-UniRule.
DR GO; GO:0006633; P:fatty acid biosynthetic process; IEA:UniProtKB-UniRule.
DR HAMAP; MF_01950; AcpH; 1.
DR InterPro; IPR007431; ACP_PD.
DR InterPro; IPR023491; ACP_phosphodiesterase_gpbac.
DR PANTHER; PTHR38764; ACYL CARRIER PROTEIN PHOSPHODIESTERASE; 1.
DR PANTHER; PTHR38764:SF1; ACYL CARRIER PROTEIN PHOSPHODIESTERASE; 1.
DR Pfam; PF04336; ACP_PD; 1.
DR PIRSF; PIRSF011489; DUF479; 1.
PE 3: Inferred from homology;
KW Fatty acid biosynthesis; Fatty acid metabolism; Hydrolase;
KW Lipid biosynthesis; Lipid metabolism; Reference proteome.
FT CHAIN 1..193
FT /note="Acyl carrier protein phosphodiesterase"
FT /id="PRO_1000070623"
SQ SEQUENCE 193 AA; 22942 MW; 0DE6F0DBE1D6C523 CRC64;
MNFLAHLHLA HLAESSLSGN LLADFVRGNP EESFPPDVVA GIHMHRRIDV LTDNLPEVRE
AREWFRSETR RVAPITLDVM WDHFLSRHWS QLSPDFPLQE FVCYAREQVM TILPDSPPRF
INLNNYLWSE QWLVRYRDMD FIQNVLNGMA SRRPRLDALR DSWYDLDAHY DALETRFWQF
YPRMMAQASH KAL
//