ID MED14_NEOFI Reviewed; 1093 AA.
AC A1DG38;
DT 11-SEP-2007, integrated into UniProtKB/Swiss-Prot.
DT 23-JAN-2007, sequence version 1.
DT 27-NOV-2024, entry version 82.
DE RecName: Full=Mediator of RNA polymerase II transcription subunit 14;
DE AltName: Full=Mediator complex subunit 14;
GN Name=rgr1; Synonyms=med14; ORFNames=NFIA_082960;
OS Neosartorya fischeri (strain ATCC 1020 / DSM 3700 / CBS 544.65 / FGSC A1164
OS / JCM 1740 / NRRL 181 / WB 181) (Aspergillus fischerianus).
OC Eukaryota; Fungi; Dikarya; Ascomycota; Pezizomycotina; Eurotiomycetes;
OC Eurotiomycetidae; Eurotiales; Aspergillaceae; Aspergillus;
OC Aspergillus subgen. Fumigati.
OX NCBI_TaxID=331117;
RN [1]
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC STRAIN=ATCC 1020 / DSM 3700 / CBS 544.65 / FGSC A1164 / JCM 1740 / NRRL 181
RC / WB 181;
RX PubMed=18404212; DOI=10.1371/journal.pgen.1000046;
RA Fedorova N.D., Khaldi N., Joardar V.S., Maiti R., Amedeo P., Anderson M.J.,
RA Crabtree J., Silva J.C., Badger J.H., Albarraq A., Angiuoli S., Bussey H.,
RA Bowyer P., Cotty P.J., Dyer P.S., Egan A., Galens K., Fraser-Liggett C.M.,
RA Haas B.J., Inman J.M., Kent R., Lemieux S., Malavazi I., Orvis J.,
RA Roemer T., Ronning C.M., Sundaram J.P., Sutton G., Turner G., Venter J.C.,
RA White O.R., Whitty B.R., Youngman P., Wolfe K.H., Goldman G.H.,
RA Wortman J.R., Jiang B., Denning D.W., Nierman W.C.;
RT "Genomic islands in the pathogenic filamentous fungus Aspergillus
RT fumigatus.";
RL PLoS Genet. 4:E1000046-E1000046(2008).
CC -!- FUNCTION: Component of the Mediator complex, a coactivator involved in
CC the regulated transcription of nearly all RNA polymerase II-dependent
CC genes. Mediator functions as a bridge to convey information from gene-
CC specific regulatory proteins to the basal RNA polymerase II
CC transcription machinery. Mediator is recruited to promoters by direct
CC interactions with regulatory proteins and serves as a scaffold for the
CC assembly of a functional preinitiation complex with RNA polymerase II
CC and the general transcription factors (By similarity). {ECO:0000250}.
CC -!- SUBUNIT: Component of the Mediator complex. {ECO:0000250}.
CC -!- SUBCELLULAR LOCATION: Nucleus {ECO:0000305}.
CC -!- SIMILARITY: Belongs to the Mediator complex subunit 14 family.
CC {ECO:0000305}.
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DR EMBL; DS027696; EAW18345.1; -; Genomic_DNA.
DR RefSeq; XP_001260242.1; XM_001260241.1.
DR AlphaFoldDB; A1DG38; -.
DR STRING; 331117.A1DG38; -.
DR EnsemblFungi; EAW18345; EAW18345; NFIA_082960.
DR GeneID; 4586799; -.
DR KEGG; nfi:NFIA_082960; -.
DR VEuPathDB; FungiDB:NFIA_082960; -.
DR eggNOG; KOG1875; Eukaryota.
DR HOGENOM; CLU_003573_1_1_1; -.
DR OMA; ITQGYIP; -.
DR OrthoDB; 2719576at2759; -.
DR Proteomes; UP000006702; Unassembled WGS sequence.
DR GO; GO:0070847; C:core mediator complex; IEA:TreeGrafter.
DR GO; GO:0016592; C:mediator complex; IEA:InterPro.
DR GO; GO:0003712; F:transcription coregulator activity; IEA:InterPro.
DR GO; GO:0006357; P:regulation of transcription by RNA polymerase II; IEA:InterPro.
DR InterPro; IPR055122; Med14_N.
DR InterPro; IPR013947; Mediator_Med14.
DR PANTHER; PTHR12809; MEDIATOR COMPLEX SUBUNIT; 1.
DR PANTHER; PTHR12809:SF2; MEDIATOR OF RNA POLYMERASE II TRANSCRIPTION SUBUNIT 14; 1.
DR Pfam; PF08638; Med14; 1.
PE 3: Inferred from homology;
KW Activator; Nucleus; Reference proteome; Transcription;
KW Transcription regulation.
FT CHAIN 1..1093
FT /note="Mediator of RNA polymerase II transcription subunit
FT 14"
FT /id="PRO_0000304605"
FT REGION 1..61
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT REGION 1035..1060
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 15..32
FT /note="Polar residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 39..61
FT /note="Basic and acidic residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
SQ SEQUENCE 1093 AA; 120836 MW; EF3E879A3EF3C532 CRC64;
MPGVIMDNAT VGRLGHAPDT QTPSNGDNLR NGSLHINGAA KGDKDHDPDK ESYTGKPKID
GHRALPELPH ITQGFFPFST LVNRYVQQCW NELSDLITEL AAIQVSPHSS MPLLPANGKS
PGNQSPENVQ KKLRILDFAH AKRAEFIKLL VLSQWSRRAH DVSKLIDLQN FIRSRHQAFV
DALQRVGEMK RDLVQAQVAN PDLQTALEIL SKGRLESLAD LGYKSSKLLT ARGALKRLHR
INRIISARLA LHDSIPHPFR TYRVHDGRVT FVVRGEFELD LSVGAESELS QFFFVDIRFL
YSPSSNIPNG RMSNEIDAKI NDKLRDSGLT GCFNFLHGLV LTNKIHILFK QAIELAKGLW
SETLRVELLH RTLVIQYWAL KPGPKSWVEI GVKSGNGDAD SQGVGVPCLG LRWMRDGQEV
DSRDIEFDPE DLSMECLLRS VIALHISYLL SSAYGILSEY SLFSTGTLSS QAILNVTEPG
ECQLSVQLTG SRHLRVSIEP MSGAVTLSAT PGLSERSESD ASLDRSTIDD LVARVSRLRC
IAAIEELESN VRILGFETVS PKGLRNEIRT VFPANVLRFS LFWHPSWERN WVVAATSSIT
GDNWWVVQLR RSSEVATDFS VSDTSVPLCS GHSMSDTFLA TSHQTRSSSF PDLGYCLSGM
VAIYANVSYL SDLQSVEFHP PLCALKVESD LQIPDIFIRY QVSKLPRALQ LVLPAGLKRK
NLLKDTVRLA FHGIDRHKNS AIFVAYGNLV GPWTDLCTLV SKSDSSLVFK RGGSGFALRL
LAPAGRPVIV QLFKSLQTLE CTLSILDFLR QRRLTPQSLS LTHIAFAYGP RRDLSAIIGI
GLSEVPSSAE LDPVRILART DPLLFLTLGI RFKHPNPHRR VQGSLAAILN HASNEAGLDF
VTEILSFTLP LMRALEQITS NASRQESFRL QVIVRNACTF LLHYTYQGFR FQLTTSQHSG
QLTWVLRELS SPGAGPGHDQ LKARLRGTLY HSNGNGWKGL GNGVVADVEG VSNVIWALDG
CFTGAQHNTW LPRETKSDQD YSTQPVPEKQ SQTGAPSQAA MANDTTITAN FVNDKSLQRN
PVASNAADVI TID
//
