#=GF ID   pNTSase1
#=GF AC   PF20301.3
#=GF DE   Predicted novel nucleotide synthetase
#=GF AU   Aravind L;0000-0003-0771-253X
#=GF AU   Iyer LM;0000-0002-4844-2022
#=GF AU   Chuguransky S;0000-0002-0520-0736
#=GF SE   Aravind L
#=GF GA   25.00 25.00;
#=GF TC   25.10 88.20;
#=GF NC   23.70 23.50;
#=GF BM   hmmbuild HMM.ann SEED.ann
#=GF SM   hmmsearch --cpu 4 -Z 81514348 -E 1000 HMM pfamseq
#=GF TP   Family
#=GF RN   [1]
#=GF RM   32868406
#=GF RT   Identification of Uncharacterized Components of Prokaryotic
#=GF RT   Immune Systems and Their Diverse Eukaryotic Reformulations.
#=GF RA   Burroughs AM, Aravind L;
#=GF RL   J Bacteriol. 2020; [Epub ahead of print]
#=GF DR   INTERPRO; IPR046875;
#=GF DR   SO; 0100021; polypeptide_conserved_region;
#=GF CC   Conserved genome contexts in NAD+-derived nucleotide-activated
#=GF CC   effector systems predict a function as a
#=GF CC   previously-uncharacterised nucleotide synthetase [1].
#=GF SQ   22
#=GS A0A514WJ22_9SPHN/1-161   AC A0A514WJ22.1
#=GS A0A4R1UTB0_9SPHN/1-162   AC A0A4R1UTB0.1
#=GS K9DFD1_SPHYA/1-157       AC K9DFD1.1
#=GS A0A1Y2QL54_9SPHN/28-198  AC A0A1Y2QL54.1
#=GS A0A0F5PG81_9SPHN/3-159   AC A0A0F5PG81.1
#=GS T0J6J6_9SPHN/1-156       AC T0J6J6.1
#=GS A0A9J9H979_RHIWR/3-163   AC A0A9J9H979.1
#=GS A0A0Q8QHF8_9SPHN/3-159   AC A0A0Q8QHF8.1
#=GS A0A931HFE4_9SPHN/1-156   AC A0A931HFE4.1
#=GS A0A5D0WLW4_9SPHN/1-157   AC A0A5D0WLW4.1
#=GS A0A0Q8R8S4_9SPHN/3-163   AC A0A0Q8R8S4.1
#=GS A0A848QS89_9SPHN/1-188   AC A0A848QS89.1
#=GS A0A0N1EEN1_9SPHN/1-156   AC A0A0N1EEN1.1
#=GS A0A1W7MHB7_9SPHN/3-156   AC A0A1W7MHB7.1
#=GS G2IMC4_SPHSK/1-158       AC G2IMC4.1
#=GS A0A1G6IGY7_9SPHN/2-157   AC A0A1G6IGY7.1
#=GS A0A4T3EYH0_9SPHN/1-130   AC A0A4T3EYH0.1
#=GS T0K1Y6_9SPHN/1-156       AC T0K1Y6.1
#=GS A0A0N1B919_9PROT/8-183   AC A0A0N1B919.1
#=GS W1RZ64_9SPHN/3-159       AC W1RZ64.1
#=GS D9QIQ4_BRESC/38-198      AC D9QIQ4.1
#=GS A0A0Q8X910_9SPHN/24-186  AC A0A0Q8X910.1
A0A514WJ22_9SPHN/1-161              .....MSTLDYTQYGLAPWLVtedkTEDWNATAPIVFNVVLGTNGQSVVLEYQLPDY..PDQD---...............YISVTCNSTIQINLV.....S.DQ.LFFSKEFEGITTK-EPLSSFYGGV.EY........CNYDKEFGRYKTVLFKARFNKGGK....LGTCHRFNVNVDLLQYTS.AGEP...TWIGLAIDPDIKNPPP
A0A4R1UTB0_9SPHN/1-162              .....MSTQNYTEFGLSPWLEpdvqAENWGAEAPIYFYVSLKAKHDRIALKYHVKDA..PEDQ--D...............YIAITTNSTVQITLE.....G.EQ.LWFSKAYEGITTK-DPLSSYYGGV.EY........VDYDKRLDRYKSLRFKARYNVGGK....LGTCHGFNLNVDLLQWGD.DGEP...KWISLSIDPDIKNPPP
K9DFD1_SPHYA/1-157                  .....MSTLNYTQYGLAPLIE....VELEDGVAPLQFNVALRGEKGWVSLRYEQPGV..TDHD---...............YIAITENSIVEINLI.....G.DQ.LFFSKNYDAITTE-EPLSSFYGGL.IY........DDYHADQDRYKTVRFQARYNQGGK....YGTRHGFNINIDLLQNPS.ATEP...KWIPLSIDPDIKNPPP
A0A1Y2QL54_9SPHN/28-198             ....i-TGKDGATAPVVQALQ...fVPRYYDDGEDGAGANVGASPEAIQAAISGFIG..RNPPAVEpvd.........gplDFGLVYKCYVVIRLE.....G.EF.WEFARE-DAVTTKQQHANARYYNLrTH........SRHGD--DRISAVSFCARTPLRLWdasgIGVKHGFNLHVDFVERARdGTVI...RRLPVIIDPDVENRGN
A0A0F5PG81_9SPHN/3-159              .....VCRPSYVQQPIAVLPP....-AGVTPAETIRFIVFFGVEEGQVALRYEQEKT..RNQD---...............YIAIARDALVEIVLQ.....G.EQ.LYLSKDMDAVTTK-DALAAFYGGL.EY........DGYDEKLDRYRIARFTARYNRGGK....YDTTHGFNINVDFLQGICpDNGP...KWIALTIDPDIKNPPP
T0J6J6_9SPHN/1-156                  .....MSTLNYTQYGLSPDFD....LGLADDATVVPFRVTLEVVDAAISLHYEVVGK..EKLH---...............YIPITCDSKVEIELV.....G.DQ.LFFSKAWDAITTK-EALSSYYGGL.EY........DKYDKQLDRYKVVRFQARFNRGGK....LGTRHPFNINVDLLQGTR.-CDP...RWVGLTIDPDIKNPPP
A0A9J9H979_RHIWR/3-163              ....t-CRPTYIQQPLGRLAP....-HGIKPARTIRFHVLMGVEDGRIALRYHQEKA..DGHDPVEq.............eYIAIEEDAVVEIHLH.....G.DQ.IFFSKELDAITTK-EELDGFYGAL.EY........DGYDEKLDHYRVARFVAKHNKGGK....YDTTHPFNINVDFLQQHC.GGKP...KWIVLTIDPDIKNPPP
A0A0Q8QHF8_9SPHN/3-159              .....VCRPSYVQHPIAVLAP....-SGVTPAETVRFVVVLGVEDGRIALRYEQDKT..RNQD---...............YIAIARDAVVEIELQ.....G.EQ.LYFSKDADGVTTK-DALGVFYGGL.EY........DGYDEKLDRYRIARFTARYNRGGK....YDTTHGFNINADFLQGYCpEGGP...KWIAITIDPDIKNPPP
A0A931HFE4_9SPHN/1-156              .....MSTLNYTQYGLAPLLD....LGLDEAAEPLVFTVTLGVKDGQIVLDYAQKS-..SGKD---...............YIAITCNSFVEIVLE.....G.DQ.LYFSKEFDAITTK-ETLSSYYGSV.SY........GAYDPKLDRYKTVRFAARYNEGGK....VGTIHRFNINVDLLQPGT.DGEP...RWIGLTIDPDIKNPPP
A0A5D0WLW4_9SPHN/1-157              .....MSTINYKQYGLAPFFD...sLSLEQSARSVVYKVTLAVREGQVVLSCRD-AD..TGKD---...............YIEISEDCFVTIQLD.....G.DQ.LFFSDAYEAITTK-EELSSYYGGL.VY........ADYDKAYGRYKTVQFKARFNAGGK....YGTVHPFNINVDLLQEDE.KGNR...RWTGISIDPDITNPPP
A0A0Q8R8S4_9SPHN/3-163              .....MCRPTYIQQQLGRLAP....-VGIKPAGTIRFHILLGVEDGRVALRFEQERA..REKDRAAy.............dYVAIEEDMVVEVTLH.....G.DQ.LYFSKEMDAVTTK-EELSFFYGGL.EY........DGYEEKLDRYRIARFAARHNSGGK....YDTTHGFNVNVDFLQRHD.EAGP...KWIAMTIDPDIKNPPP
A0A848QS89_9SPHN/1-188              mprgg-----YEQHRINHDRP...tRETPEHSATIKLDFEAEASPGRIIFTSGLTTG..PEKPVTLlakn......ngkvaSINVRKNCVINLVLDhidcdGnEKwWRFSNQYDAITTK-EELRDFYGKL.KYlpdeaithPDNDDIILGYRKVSFVIKHNRDGR....MGSSHGFSINIDLLQSDP.DSNPddwEWLPITIDPEIKNPPG
A0A0N1EEN1_9SPHN/1-156              .....MSTLNYMQYGLANQLD....-LELTGEEPIVFNVILKAEEGRIVLEYDQPAA..PGQD---...............YIAITCDSVVDITLV.....G.DQ.LWFSKEFDAITTK-EPLSSFYGGL.EY........SAYDEKLDRYKAVRFNARFNQGGK....YGTRHRFNINVDLLQDIN.ACEP...RWIGLTIDPDIKNPPP
A0A1W7MHB7_9SPHN/3-156              ....q-CSPAQYALPHDPELR....---TAAGKALTFTISLYARNGAIVLKMDQDGQ..EAQD---...............YIAITEDTMVEIVLK.....G.DQ.LFFSKAFDAITMKDANLGAFYGNL.EY........DGYDEKLDRYKIVRFVARFNKGGK....FGTTHAFNVNIDLLQKSR.-RGP...RWIGMSIDPDIKNPPP
G2IMC4_SPHSK/1-158                  .....MYGPSYVQKQLAPFAP....PEAASTTNKVRFDITLGAKDGAVVLEFEQAGC..PGQD---...............FITITEDCFVEIVLH.....G.DQ.IFFSKDLDGITTK-TELASFYGGL.TY........EQYDRKTGRYRMVSFHARYNNGGQ....AGTIHGFNVNVDLFRGFDdQRQP...KWTALTIDPDIKNPPP
A0A1G6IGY7_9SPHN/2-157              .....MTHRKMAQYPLSLAAP....TGVEPRNAIVNFSVTLTA-DGRDIILVMEDME..TGKD---...............YIAIKEHSDVKIVLR.....G.DQ.IFFSKEHDGITMKDDDLGHLYGGL.EY........GDYDKELDRYRSVKFVACFNKGGK....VGTKHPFNINVDLLQGGS.-KAP...RWIGLTIDPDITNPPP
A0A4T3EYH0_9SPHN/1-130              ....m----------------....------------NVTLCVADGRIALKLVPEPCrvEGQD---...............YVAIEGNSAVVIKLI.....G.EQ.VFFSKQYDAITMK-GDFARYYGDL.AY........SELDEETGRYKCVTFRARFDKEGK....TDSSHPFNINVDLYLP--.GSKP...EWVPITIDPDIKNPPP
T0K1Y6_9SPHN/1-156                  .....MSTLNYQHCGLAPQFP....-LGVADDKPIRFHVTLKAQNDRIVLRFEQPDV..PGRD---...............YIAIKKDSIVEIVLK.....G.DQ.LYFSKDIDGITTK-QPLASFYGGL.EY........DGYDEKLDRYKIARFRARFNKGGK....YGTRHAFNVNVDLLQLSP.SGEP...QWTALSIDPDIKNPPP
A0A0N1B919_9PROT/8-183              ....l-TLPAGSGADPVTALD...wHIVGFTEADRGVGRGTPATDADTTEKLIAEFL..AAPEVARpdadgkppaqadallDFTTFGKQLVVFRLV.....G.GL.WQFAA--PGITTKLPQAGPGYAGLvGY........RLTDCGAEEFADASGCRAVSFEVSeaieAGTT-AINFHVDFVDAGS.K---...RLLPVIIDPDGSNLPK
W1RZ64_9SPHN/3-159                  .....MSTHNYTQYGLEPLFE....VELEDGVAPIQFDVVLKAEDGRIVLRYEQPGV..KDNA---...............YIAIRRNSIVEITLI.....G.DQ.LFFSKDYDAITTK-EPLASFYGGL.TY........DDYDRKLDRYKKVRFQARYNQGGK....YGTRHRFNINVDLLQNPG.AAAP...EWIALSIDPDIKNPPP
D9QIQ4_BRESC/38-198                 ....r-TRPEGERVVPNPGSH...vMHGADIDAFIAARVKGRPLPPADAVYRQAGDD..PAQERPI...............NIFVSEQCWLVIELD.....PsEK.WQFTPGAPGITTSTDHKAANWGLMhVM........SDGTIADGKGPTRDGCRLIYFGVNa.rrTNEHQRFICNIDLS----.GVGL...T--DLLVDPDIPNDGG
A0A0Q8X910_9SPHN/24-186             ....y-IKSAGPANGPTPALT...fHIENTEGGIPGYELKPGERPEDVIAKFVAGSV..PFTRNPTp.............lDFPISKKCYIVLKLE.....G.DF.WEFDAR-DGVTTK-EDLGGQYYRLiPH........SQG----GRIAAVSFCARTPFPDRpaedDRVRHSINLHINFLDRDA.SGNV...RRLPVIIDPDVENRGG
#=GC seq_cons                       .....hsp.sYhQhslushhs.....thhssstsltFpVsLtspcGplsLcapttss..sspD..................YIuIsccshVpIpLp.....G.DQ.laFSKphDuITTK.-sLuuaYGGL.pY........ssYDcchDRY+sVcFpARaNpGGK....hGTpHsFNlNVDLLQtss.sstP...+WluloIDPDIKNPPP
//