#=GF ID   Suppressor_P21
#=GF AC   PF11479.13
#=GF DE   RNA silencing suppressor P21 C-terminal domain
#=GF AU   Pollington J;0000-0002-8158-8998
#=GF AU   El-Gebali S;0000-0003-1378-5495
#=GF SE   pdb_2cwo
#=GF GA   26.90 26.90;
#=GF TC   29.00 33.00;
#=GF NC   26.60 24.60;
#=GF BM   hmmbuild HMM.ann SEED.ann
#=GF SM   hmmsearch --cpu 4 -E 1000 -Z 81514348 HMM pfamseq
#=GF TP   Domain
#=GF RN   [1]
#=GF RM   16154094
#=GF RT   RNA silencing suppressor p21 of Beet yellows virus forms an RNA
#=GF RT   binding octameric ring structure. 
#=GF RA   Ye K, Patel DJ; 
#=GF RL   Structure. 2005;13:1375-1384.
#=GF DR   INTERPRO; IPR021575;
#=GF DR   SO; 0000417; polypeptide_domain;
#=GF CC   P21 is produced by Beet yellows virus to suppress the antiviral
#=GF CC   silencing response mounted by the host. P21 acts by binding
#=GF CC   directly to siRNA which is a mediator in the process. P21 has an
#=GF CC   octameric ring structure with a large central cavity [1]. This
#=GF CC   is the C-terminal domain. The N-terminal domain is Pfam:PF11757.
#=GF SQ   8
#=GS P21_BYVU/95-174          AC Q08545.1
#=GS P21_BYVU/95-174          DR PDB; 2CWO B; 95-174;
#=GS P21_BYVU/95-174          DR PDB; 2CWO C; 95-174;
#=GS P21_BYVU/95-174          DR PDB; 2CWO A; 95-174;
#=GS P21_BYVU/95-174          DR PDB; 2CWO D; 95-174;
#=GS A0MBX2_9CLOS/97-174      AC A0MBX2.1
#=GS A0A0K1HRT6_9CLOS/94-173  AC A0A0K1HRT6.1
#=GS Q66244_9CLOS/95-173      AC Q66244.1
#=GS Q49IG5_9CLOS/92-170      AC Q49IG5.1
#=GS V5IV74_9CLOS/94-173      AC V5IV74.1
#=GS Q5G7F9_9CLOS/97-175      AC Q5G7F9.1
#=GS A0A385HW53_9CLOS/94-173  AC A0A385HW53.1
P21_BYVU/95-174                     ......TPMHKETASDTLNAFLEEYCRITGLAREDALREKMRKVKSVVLFHHSELLKFEVTENMFSYTELLKLNLSLRVISSQILG.......
#=GR P21_BYVU/95-174          SS    ......-TT--SSHHHHHHHHHHHHHHHH---HHHHCCSBHHHHHHHHHHHHHHHHTS---GGGSTTHHHHH--SBHHHHHHHTT-.......
A0MBX2_9CLOS/97-174                 dvlgir------SIHDTFHFMINKFSELTNVPLSEVYEMKMKHVSTLVIREMIREHRLDISETCFPGHGILNLKMKT---------gavkhll
A0A0K1HRT6_9CLOS/94-173             ....rd--IIDLSTEDTLRFFVARFMEVTSHTKDESLSYNVRDIVNTVLRRISSERSLDVSTNTFKQCDLLRMQKSLRSVWKHTLG.......
Q66244_9CLOS/95-173                 ......DKLLCTSATDVMGFFVMRYMSSSHTSFESVMRTELRLVVKAVLSDLSRAHKLDFSERAFAAYGIL-LQKGTVSTVCGQFD.......
Q49IG5_9CLOS/92-170                 ...hfc----KDEPKELVAFITRKYVELTGVGIRDVVKMEMRSLTRAVLNKLSLEMAFYVSPRAWKNAEWLELKFSPVKIFRD---lll....
V5IV74_9CLOS/94-173                 ......TPMHAESASATFEAFLREFCKITGLTRENAMLENMRKVKSTVLFHHSDLLGFEITENMFRYSELLKLNLKLRVVSSRILG.......
Q5G7F9_9CLOS/97-175                 ......DQLN-LESKELLAFFVKYFTNITPTSFDHAIEYSVRQLVSAVLLHLSSESGLDISANTFRQNVLLRSNNKVIVEWTRRLG.......
A0A385HW53_9CLOS/94-173             ....hd--LINLDNKDLIKYFVTKYMTITSRTLDTTLAARTKDVSTVVLRNLSTEKGLNISTNTFKQSELLRLKSKLGIVWKYHL-g......
#=GC SS_cons                        ......-TT--SSHHHHHHHHHHHHHHHH---HHHHCCSBHHHHHHHHHHHHHHHHTS---GGGSTTHHHHH--SBHHHHHHHTT-.......
#=GC seq_cons                       ........hhp.oscDslpFFlp+asclTuhoh-cslchchRcVsosVLp+lSpEpuL-lSpNsF+ts-LL+LphplhslhpphLs.......
//