#=GF ID RTX
#=GF AC PF02382.20
#=GF DE N-terminal domain in RTX protein
#=GF AU Mian N;0000-0003-4284-4749
#=GF AU Bateman A;0000-0002-6982-4660
#=GF SE Pfam-B_833 (release 5.2)
#=GF GA 26.80 26.80;
#=GF TC 27.00 26.80;
#=GF NC 26.50 26.70;
#=GF BM hmmbuild HMM.ann SEED.ann
#=GF SM hmmsearch --cpu 4 -Z 81514348 -E 1000 HMM pfamseq
#=GF TP Domain
#=GF RN [1]
#=GF RM 9628576
#=GF RT Complete nucleotide sequences of 93-kb and 3.3-kb plasmids of an
#=GF RT enterohemorrhagic Escherichia coli O157:H7 derived from Sakai
#=GF RT outbreak.
#=GF RA Makino K, Ishii K, Yasunaga T, Hattori M, Yokoyama K, Yutsudo
#=GF RA CH, Kubota Y, Yamaichi Y, Iida T, Yamamoto K, Honda T, Han CG,
#=GF RA Ohtsubo E, Kasamatsu M, Hayashi T, Kuhara S, Shinagawa H;
#=GF RL DNA Res 1998;5:1-9.
#=GF RN [2]
#=GF RM 30405113
#=GF RT Cytotoxic activity of Kingella kingae RtxA toxin depends on
#=GF RT post-translational acylation of lysine residues and cholesterol
#=GF RT binding.
#=GF RA Osickova A, Balashova N, Masin J, Sulc M, Roderova J, Wald T,
#=GF RA Brown AC, Koufos E, Chang EH, Giannakakis A, Lally ET, Osicka R;
#=GF RL Emerg Microbes Infect. 2018;7:178.
#=GF DR INTERPRO; IPR018504;
#=GF DR TC; 1.C.11;
#=GF DR SO; 0000417; polypeptide_domain;
#=GF CC The RTX family of bacterial toxins are a group of cytolysins and
#=GF CC cytotoxins that have RTX (Repeat in ToXin repeats) Pfam:PF00353.
#=GF CC This is a hydrophobic pore-forming domain found at the
#=GF CC N-terminal of these proteins [2].
#=GF SQ 21
#=GS A0A2T1DXM8_9CYAN/14-128 AC A0A2T1DXM8.1
#=GS A0A238HI88_9NEIS/298-604 AC A0A238HI88.1
#=GS A0A5B0DZM7_9HYPH/236-409 AC A0A5B0DZM7.1
#=GS A0A380MT91_9GAMM/421-739 AC A0A380MT91.1
#=GS A0A5B0E4H1_9HYPH/462-668 AC A0A5B0E4H1.1
#=GS E3BKQ9_9VIBR/744-1065 AC E3BKQ9.1
#=GS A0A066UM22_9GAMM/265-571 AC A0A066UM22.1
#=GS A0A517MLK1_9BACT/6-142 AC A0A517MLK1.1
#=GS F5S905_KINKI/287-593 AC F5S905.1
#=GS CYAA_BORPE/588-896 AC P0DKX7.1
#=GS CYAA_BORPE/588-896 DR PDB; 7USL C; 754-896;
#=GS A3N292_ACTP2/288-596 AC A3N292.1
#=GS A0A640VVZ5_9RHOB/566-876 AC A0A640VVZ5.1
#=GS A3N0W6_ACTP2/288-592 AC A3N0W6.1
#=GS Q46716_ECO57/278-586 AC Q46716.2
#=GS A0A5R8KKD4_9BACT/5-149 AC A0A5R8KKD4.1
#=GS A0A011P8N8_9PAST/277-583 AC A0A011P8N8.1
#=GS A0A5B0E0B9_9HYPH/421-622 AC A0A5B0E0B9.1
#=GS A0A925RH87_9CYAN/12-137 AC A0A925RH87.1
#=GS A0A0H2VC10_ECOL6/292-600 AC A0A0H2VC10.1
#=GS A0A5B0DWI5_9HYPH/457-633 AC A0A5B0DWI5.1
#=GS A4ES15_9RHOB/402-709 AC A4ES15.1
A0A2T1DXM8_9CYAN/14-128 ....................................anpdpi---------........----------...----------------------------------------------------TGEPGAHPVGTGVGAAGAGAAGAAVGGAIGGPVGAVVGAVVGAVSGGLAGK------NVAERVN---......-----------------------..--..--------------------------------------..-..--..---.-------------.......------------------------------...---------------------..------.-.-----------.-------------.---------ptveeaywrenyasrpyvepdhdytdyepayrtgyegysshhdqgvtydqa
A0A238HI88_9NEIS/298-604 ..........................................LAQRAAAGL........STTGAVASLI...TASIMLAISPLAFMNAADKFKNASLIDEFAKQFKKFGYDGDSLLAEYQRGAGTIEASLTAINTALGAVSAGVSAAAVGSVVGSPVALLVAGVTGLISGILEASKQAMFESVANRLQSKI......LAWEKENGGKNYFENGYDARHAH..YL..ERNLKLLSELNKELQAERVIAITQQRWDANIGELAGIT..K..LG..DRV.SSGKAYADAFEDG.......KKLDGAS----NVTVDTRTGVVDISNANGK...KTQALHFTSPLLTAGTETRER..VQNGKY.S.YINQLKFNRVK.SWTVKDGEANSRL.DFSKVIQHV...................................................
A0A5B0DZM7_9HYPH/236-409 .........................sanhilssygitsgssa---------........----------...-----------------------------------------------------------------------------------------------------------------------......--EDIARAKAQFWGDGFDSREKG..LR..DGYVAAMRKIADTTEAKRVIAITGQELRSDQATIAGFT..G..LI..PD-.NSNRNYMYVLEGG.......------KNDRLVLTSDK----IDVTSNA--...QSQYVAFLSPVMPISGEERQT..LIDGKQ.T.THGLKRPTKVD.VMHLIDGNSDTTF.DPRNI----atl................................................
A0A380MT91_9GAMM/421-739 ............gldvglksvgtvatsvsvigdsiakilgtt---------........-TILPQIGAA...VSGLALAASPLEIKGLIDENVHVKEVNKLGDETQIFGYEGDKILADLLHEKFVLNTAYTATDIALNITTTAISTAAAASVVGAPVAAVVGVVRGVIGGILAAVKQPSLEVIADRYAQKI......R---DYGDVTAFFNTNKEALLNQ..FYqtDAVRDSFKQLQNFYKVDSVITLDGAASSSTAMELAAHT..K..LI..DQM.NKANNYAQLIRDG.......-EINKDD-SAKYLTMDSLTGVLTI---NTP...KDSLIKFNSPLFTPGAEESTR..KQVGKN.A.YYTDLMINGPD.KHTIIDGDSSN--.---------ifisn..............................................
A0A5B0E4H1_9HYPH/462-668 avisaipianlfsgflqfafngdalghtilkdylgragadgt---------........----------...-----------------------------------------------------------------------------------------------------------------------......----VESAVQDFWNDGFDTREKQ..AQ..QGYIDSMKALAASTEVKRVVAVTGQELRADMAQVAGITggK..IA..QGV.KSGVNYMYV-EDGs.....sAKPSKNGLYGQSLVSD----IIDINS--GA...SSQYFTMLTPLMRVTDESRAS..AVAGKNtR.YGSSLPRAGDK.AMEIVDGASHTTA.DVRN-----fas................................................
E3BKQ9_9VIBR/744-1065 ..........................................LAMGLTVGVltakaaitGTTVSSAVPVlgiVASLASAINPVQWAAFEQSKDHINDVDAKTDESSDAYETSAQYLTELLEDIHGTEVGFYSASTAVGVLGGIGTTAAAATGVGAPVALVIAGITAGLQGMLEGLKQVHLDNVAEDMAEKI......R--AFNEGVAGFFDQSFEHSTDK..AL..SDFVDDAKHFIEK-GYDSVSGLGSVQMTASDLELAGLS..G..VG..GEL.KQTQKHFSGFIEK.......ADLETGEWNREEIKIDASQGVIERTNVNGAatgKDNMLTFVTPMAAAGNENIST..EHVSKN.R.YETTINISNLK.GWTIKDGGDNTTF.DLDNIVTKA...................................................
A0A066UM22_9GAMM/265-571 ..........................................LAQRVAAGL........STTGAVAALI...TSSIMLAISPLAFVNAVDKFNHANALDEFAQQFQKFGYDGDHLLAEYQRGVGTIEASLTTINTALGAVSAGVSAAAVGSAVGAPIALLVAGVTGLISGILEASKQAMFESVANRLQGRI......LEWEKQNGGQNYFDKGYDSRYAA..YL..ANNLQFLSELNKELEAERVIAITQQRWDNNIGELAGIT..K..LG..EKV.ESGKAYVDAFEDG.......KKVEAGV----NITLDAKTGIVDISNSDSK...KTQALHFTSPLLSAGNESRER..ISNGKY.S.YINKLKFERVK.NWQITDGDASSKL.DFSKVIQRI...................................................
A0A517MLK1_9BACT/6-142 ..............................tereetreelrn---------........----------...------------------------------------------------EDAITGEPGSHPVGTGVGTALGGVAAGAAAGAVGGPIGTVAGAVIGGVAGGLAGK------AVAENIDPTVe....aAYWEEQHQSRPYYDDAYEYNHYHpaYQ..AGWEAYDADANEDWAARE--ALARQRWEN---------..-..--..---.-------------.......------------------------------...---------------------..------.-.-----------.-------------.---------egga...............................................
F5S905_KINKI/287-593 ..........................................LAQRAAAGL........STTGAVASLI...TASIMLAISPLAFMNAADKFKNASLIDEFAKQFKKFGYDGDSLLAEYQRGAGTIEASLTAINTALGAVSAGVSAAAVGSVVGSPVALLVAGVTGLISGILEASKQAMFESVANRLQSKI......LAWEKENGGKNYFENGYDARHAH..YL..ERNLKLLSELNKELQAERVIAITQQRWDANIGELAGIT..K..LG..DRI.SSGKAYADAFEDG.......KKLDGAS----NVTVDTRTGVVDISNANGK...KTQALHFTSPLLTAGTETRER..VQNGKY.S.YINQLKFNRVK.SWTVKDGEANSRL.DFSKVIQHV...................................................
CYAA_BORPE/588-896 ..........................................LALAAARGVts....glQVAGASAGAA...AGALAAALSPMEIYGLVQQSHYADQLDKLAQESSAYGYEGDALLAQLYRDKTAAEGAVAGVSAVLSTVGAAVSIAAAASVVGAPVAVVTSLLTGALNGILRGVQQPIIEKLANDYARKI......---DELGGPQAYFEKNLQARHEQ..LAnsDGLRKMLADLQAGWNASSVIGVQTTEISKSALELAAIT..G..NA..DNL.KSVDVFVDRFVQG.......-----ERVAGQPVVLDVAAGGIDIASRKG-...ERPALTFITPLAAPGEEQRRR..TKTGKS.E.FTTFVEIVGKQdRWRIRDGAADTTI.DLAKVVSQL...................................................
#=GR CYAA_BORPE/588-896 SS ..........................................XXXXXXXXXXX....XXXXXXXXXXXX...XXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXX......---XXXXXXXXXXXXXXXXXXXX..XXXX--HHHHHHHHHHHTT-S-B--BEEEE--HHHHHHHHHH..S..--..SS-.-SEEEE---BBTT.......-----B-------EEETTTTEEE----TT-...---EE-BSS-B--SS-EEE--..---TTS.B.S---EEE--S--EEEEE--SS--EE.E--SB--EE...................................................
A3N292_ACTP2/288-596 ..........................................IAQRVAAGL........STTAATGGLI...GSVVALAISPLSFLNVADKFERAKQLEQYSERFKKFGYEGDSLLASFYRETGAIEAALTTINSVLSAASAGVGAAATGSLVGAPVAALVSAITGIISGILDASKQAIFERVATKLANKI......DEWEKKHG-KNYFENGYDARHSA..FL..EDTFELLSQYNKEYSVERVVAITQQRWDVNIGELAGIT..R..KG..ADA.KSGKAYVDFFEEG.......KLLEKDPDRFDKKVFDPLEGKIDLSSINK-...-TTLLKFITPVFTAGEEIRER..KQTGKY.E.YMTELFVKGKE.KWVVTGVQSHNAIyDYTNLIQ--la.................................................
A0A640VVZ5_9RHOB/566-876 ....................maamaaegalaatamlshsaka---------........LSFATKGVPVagaVVTLLSVLDPVSWQRFDAAKDYIDHL-----RETDDGTETNGLLADRLEDTYDKEVAHYAAATAVDAAFGIASIGIAATGVGAPVAVAVALVGAAISTIIRLTEGNTWQREADKLADEMr....sLPNGDQQTIAQFFEKQLDTRWEA..IA..AENEERFDRILDK-NFDSIIGLGSQSFTDADASLAIQS..D..TI..SEMgKTAKHYGTEYLGQ.......-----GNWDHQSVTLDESAAQIDLPNGGAD...KAVYLTFMAPLMLAVEEVYTRpmFNFGKG.G.GTTTT---YVS.GWTITDGTTK---.---------ytess..............................................
A3N0W6_ACTP2/288-592 ..........................................LAQRVASGL........SSTGPVAALI...ASTVALAVSPLSFLNVADKFKQADLIKSYSERFQKLGYDGDRLLADFHRETGTIDASVTTINTALAAISGGVGAASAGSLVGAPVALLVAGVTGLITTILEYSKQAMFEHVANKVHDRI......VEWEKKH-NKNYFEQGYDSRHLA..DL..QDNMKFLINLNKELQAERVVAITQQRWDNQIGDLAAIS..R..RT..DKI.SSGKAYVDAFEEG.......QHQSYDS----SVQLDNKNGIINISNTNR-...KTQSVLFRTPLLTPGEENRER..IQEGKN.S.YITKLHIQRVD.SWTVTDGDASSSV.DFTNVVQRI...................................................
Q46716_ECO57/278-586 ..........................................LAQRMAQGL........STTAASAGLI...TSAVMLAISPLSFLAAADKFERAKQLESYSERFKKLNYEGDALLAAFHKETGAIDAALTTINTVLSSVSAGVSAASSASLIGAPISMLVSALTGTISGILEASKQAMFEHVAEKFAARI......NEWEKEHG-KNYFENGYDARHAA..FL..EDSLSLLADFSRQHAVERAVAITQQHWDEKIGELAGIT..R..NA..DRS.QSGKAYINYLENG.......GLLEAQPKEFTQQVFDPQKGTIDLSTGNV-...-SSVLTFITPTFTPGEEVRER..KQSGKY.E.YMTSLIVNGKD.TWSVKGIKNHKGVyDYSKLIQ--fv.................................................
A0A5R8KKD4_9BACT/5-149 ............................reaelehdqnldpi---------........----------...----------------------------------------------------TGEPSSHPVGTGVGALGGGLTGAAIG-AVGGPVGIVIGAAAGSVAGGLMGKNVAESQDPTDRAVEAIspeseeSHWQQQCGNEAYFDPQYNFADYA..PA..YRLGYETKELQRTSSFEDLEGILKGRWQEA--------..-..--..---.-------------.......------------------------------...---------------------..------.-.-----------.-------------.---------kgds...............................................
A0A011P8N8_9PAST/277-583 ..........................................LAQRVAAGL........STTGPVAALI...ASTVSLAISPLAFAGIADKFNNAKALESYAERFKKLGYEGDSLLAEFQRGTGTIDASVTAINTALAAISGGVSAAAAGSLVGAPIALLVSGITGIISTILQYSKQAMFEHVANKIHNRI......LDWEKKHNGKNYFENGYDSRYLA..DL..QDNMRQLLNLNKELQAERVIAITQQQWDSNIGDLAGIS..R..LG..EKV.MSGKAYADAFEEG.......KHLKADK----FVQLDSASGIIDVSNSGNA...KTQHILFRTPLLTPGVENRQR..VQTGKY.E.YITKLNLNRVD.SWKITDGAASSTF.DLTNVVQRI...................................................
A0A5B0E0B9_9HYPH/421-622 ..................................atpvinlf---------........----------...---------------------------------------------------------------------------------------------SAMFGMLDTSKRSADRILADYGVTDL.....sDSEAVSQAARKFMIDGLDARERA..VQ..ADYIAALKRIAASTETKRIIAVTGQELRADQAAVAALL..G..TAfvKEI.NSSRHYFYDLSDQ.......TRKDNGL-----VATASASNSISI--DSTA...DSQYFLFLTPIMPVTPEERAE..TISGKS.V.KNSLVPLQTLP.GFELMDGAASTVA.DIRK-----fasf...............................................
A0A925RH87_9CYAN/12-137 ...................................danpdpl---------........----------...----------------------------------------------------TGEAGAHPVGTGVGAGAAGAAGAAIGGAIGGPVGAVVGAVVGAVSGGLAGK------SVAERVNPTVe....dAYWRENYASRPYAESGYDYT---..--..--------------------------------------..-..--..---.-------------.......------------------------------...---------------------..------.-.-----------.-------------.---------dyepayrtgyegysshhdqgitydqaeptlrqnyea...............
A0A0H2VC10_ECOL6/292-600 ..........................................IAQRAAQGL........STSAAAAGLI...ASVVTLAISPLSFLSIADKFKRANKIEEYSQRFKKLGYDGDSLLAAFHKETGAIDASLTTISTVLASVSSGISAAATTSLVGAPVSALVGAVTGIISGILEASKQAMFEHVASKMADVI......AEWEKKHG-KNYFENGYDARHAA..FL..EDNFKILSQYNKEYSVERSVLITQQHWDTLIGELAGVT..R..NG..DKT.LSGKSYIDYYEEG.......KRLEKKPDEFQKQVFDPLKGNIDLSDSKS-...-STLLKFVTPLLTPGEEIRER..RQSGKY.E.YITELLVKGVD.KWTVKGVQDKGSVyDYSNLIQHA...................................................
A0A5B0DWI5_9HYPH/457-633 ..............................lileeylpktgs---------........----------...-----------------------------------------------------------------------------------------------------------------------......---SKEKAINLFWSDGFDSREKE..VQ..HEYVMLLRQMSSKVESKRVIAVTGQELRTDMAMVSALL..GgaFA..NGV.NSNRNY---FYDS.......QKLTPNE----NGMIGRGLDGIAINLESSA...TEQYFLFLTPVMVTTDKERYE..TSVGKT.TiYGTKLP-ETPH.RMVITDGASATTA.DVRNFA---ssa................................................
A4ES15_9RHOB/402-709 ..........................................LAVTAGSKA........ATVLGKAVPIigaIGSVIGAINPVKWAEFEQKQDRIDAI-------RDSGTYSSGLLGDLLQESKTAEAAFYGTTTALDVTTGVTAGVLAATGVGAPISAAVGLIGGAISAIVGAFEQVALEAIADRYADKIr....tDAEGNPQTVEAFFKGSFDQKQER..IK..EHYTEFFEEFIAENDVDRVLALGGQGLDATDIELAAIS..K..TS..GELnKTARNYVETFTTNgwqpgshALSPSSGFETNVIQLDKAHG----------...SKSFLTFTTPLFAAGTEDISR..RETGKN.E.YQTTLRIKDLS.GWEIRDHGVNETTfNMSKVVSS-a..................................................
#=GC SS_cons ..........................................XXXXXXXXXXX....XXXXXXXXXXXX...XXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXX......---XXXXXXXXXXXXXXXXXXXX..XXXX--HHHHHHHHHHHTT-S-B--BEEEE--HHHHHHHHHH..S..--..SS-.-SEEEE---BBTT.......-----B-------EEETTTTEEE----TT-...---EE-BSS-B--SS-EEE--..---TTS.B.S---EEE--S--EEEEE--SS--EE.E--SB--EE...................................................
#=GC seq_cons ............................................................s.hs.hs.h...hssl..shsPhth.th.tt...hp.l.......p.....ssthLsth.cthhsh-suhpslsTulussuuusuuAAsuohVGuPluhlVuulsGhluGhLtupcpshhcplAs+hsscI.........pcppuspsaF-sGaDuRctt..hh..pc.hphhpphscphps-RVlAlspQchcss.upLAulo..t..hu..sch.pSu+sYhphhppu.......t..p.s......lhhD..tu.lslss.ss....psphltFhoPlhssupEpRpc..hpsGK..p.Yhopl.hpthc.taplpDGtspsth.Dhpph.......................................................
//
