#=GF ID DCB
#=GF AC PF16213.11
#=GF DE Mon2/Sec7/BIG1-like, dimerisation and cyclophilin-binding domain
#=GF AU Coggill P;0000-0001-5731-1588
#=GF SE Pfam-B_11423 (release 27.0)
#=GF GA 25.60 25.60;
#=GF TC 25.60 25.60;
#=GF NC 25.50 25.50;
#=GF BM hmmbuild HMM.ann SEED.ann
#=GF SM hmmsearch -Z 81514348 -E 1000 --cpu 4 HMM pfamseq
#=GF TP Repeat
#=GF CL CL0020
#=GF RN [1]
#=GF RM 16219684
#=GF RT Yeast Mon2p is a highly conserved protein that functions in the
#=GF RT cytoplasm-to-vacuole transport pathway and is required for Golgi
#=GF RT homeostasis.
#=GF RA Efe JA, Plattner F, Hulo N, Kressler D, Emr SD, Deloche O;
#=GF RL J Cell Sci. 2005;118:4751-4764.
#=GF RN [2]
#=GF RM 16301316
#=GF RT Mon2, a relative of large Arf exchange factors, recruits Dop1 to
#=GF RT the Golgi apparatus.
#=GF RA Gillingham AK, Whyte JR, Panic B, Munro S;
#=GF RL J Biol Chem. 2006;281:2273-2280.
#=GF RN [3]
#=GF RM 27373159
#=GF RT Structural Insights into Arl1-Mediated Targeting of the Arf-GEF
#=GF RT BIG1 to the trans-Golgi.
#=GF RA Galindo A, Soler N, McLaughlin SH, Yu M, Williams RL, Munro S;
#=GF RL Cell Rep. 2016;16:839-850.
#=GF RN [4]
#=GF RM 26765562
#=GF RT The Sec7 N-terminal regulatory domains facilitate
#=GF RT membrane-proximal activation of the Arf1 GTPase.
#=GF RA Richardson BC, Halaby SL, Gustafson MA, Fromme JC;
#=GF RL Elife. 2016; [Epub ahead of print]
#=GF DR INTERPRO; IPR032629;
#=GF DR SO; 0001068; polypeptide_repeat;
#=GF CC DCB domain is found at the N-terminal of Mon2 and BIG1-like
#=GF CC proteins from metazoa, and in fungal homologues like Sec7 and
#=GF CC Gea1/2 [3,4]. Mon2 and BIG1 like proteins play an important role
#=GF CC in the cytoplasm-to-vacuole transport pathway and are required
#=GF CC for Golgi homeostasis [1,2]. This domain is sufficient for
#=GF CC targeting BIG1 to the Golgi.
#=GF SQ 8657
#=GS A0A8C8DDZ6_ONCTS/3-199 AC A0A8C8DDZ6.1
#=GS A0A0D2UG65_CAPO3/2-215 AC A0A0D2UG65.1
#=GS A0A8H8RZK5_9HELO/2-185 AC A0A8H8RZK5.1
#=GS A0A851REG9_TYCCO/8-184 AC A0A851REG9.1
#=GS A0A803KPK7_CHEQI/1-154 AC A0A803KPK7.1
#=GS A0A914L586_MELIC/24-205 AC A0A914L586.1
#=GS A0A2Y9IUB5_ENHLU/4-200 AC A0A2Y9IUB5.1
#=GS H2LWJ4_ORYLA/28-213 AC H2LWJ4.2
#=GS A0A2V5HK19_ASPV1/2-175 AC A0A2V5HK19.1
#=GS A0A6P6VXG0_COFAR/5-223 AC A0A6P6VXG0.1
#=GS A0A6A4KVL6_9ERIC/405-487 AC A0A6A4KVL6.1
#=GS A0A914IBJ8_GLORO/13-192 AC A0A914IBJ8.1
#=GS A0A7J8W9S5_9ROSI/1-203 AC A0A7J8W9S5.1
#=GS A0A671QHQ6_9TELE/7-208 AC A0A671QHQ6.1
#=GS A0A166GRU1_DAUCS/1-173 AC A0A166GRU1.1
#=GS A0A1D8PFK4_CANAL/1-174 AC A0A1D8PFK4.1
#=GS A0A2A9P526_OPHUN/2-190 AC A0A2A9P526.1
#=GS A0A1U7RSC8_ALLSI/1-112 AC A0A1U7RSC8.1
#=GS A0A7J6JAC0_COLFN/2-175 AC A0A7J6JAC0.1
#=GS B8LWF1_TALSN/2-175 AC B8LWF1.1
#=GS A0A8C0G4Q5_CHEAB/2-132 AC A0A8C0G4Q5.1
#=GS A0A8D0G5G6_SPHPU/7-212 AC A0A8D0G5G6.1
#=GS A0A022RL92_ERYGU/11-209 AC A0A022RL92.1
#=GS A0A673L8A4_9TELE/11-151 AC A0A673L8A4.1
#=GS A0A5B8MEM3_9CHLO/31-196 AC A0A5B8MEM3.1
#=GS A0A1S3NHS3_SALSA/28-212 AC A0A1S3NHS3.1
#=GS A0A0C3AYI9_9AGAM/106-302 AC A0A0C3AYI9.1
#=GS A0A1U8AFC7_NELNU/14-205 AC A0A1U8AFC7.1
#=GS A0A8T1PGH8_CARIL/88-249 AC A0A8T1PGH8.1
#=GS A0A445HEE4_GLYSO/25-247 AC A0A445HEE4.1
#=GS A0A1S2XNY0_CICAR/11-208 AC A0A1S2XNY0.1
#=GS R7QQH4_CHOCR/59-239 AC R7QQH4.1
#=GS A0A9B0WJP0_CHRAS/28-213 AC A0A9B0WJP0.1
#=GS A0A7L4DAY9_9AVES/1-172 AC A0A7L4DAY9.1
#=GS A0A804NCR1_MAIZE/1-173 AC A0A804NCR1.1
#=GS A0A2K0WMQ2_GIBNY/1-187 AC A0A2K0WMQ2.1
#=GS A0A8C3JAL4_9CHAR/6-207 AC A0A8C3JAL4.1
#=GS A0A2I2YQA5_GORGO/8-184 AC A0A2I2YQA5.1
#=GS A0A851N4X5_9DEND/2-200 AC A0A851N4X5.1
#=GS A0A8C4VGW9_9SAUR/28-213 AC A0A8C4VGW9.1
#=GS A0A7K5IRX4_TOXRE/2-200 AC A0A7K5IRX4.1
#=GS A0A061GKQ1_THECC/96-252 AC A0A061GKQ1.1
#=GS A0A814ST56_9BILA/15-214 AC A0A814ST56.1
#=GS A0A8C4SPR7_ERPCA/1-168 AC A0A8C4SPR7.1
#=GS A0A178Z593_9EURO/2-174 AC A0A178Z593.1
#=GS A0A2Y9QJB2_TRIMA/28-213 AC A0A2Y9QJB2.1
#=GS A0A8M3ANJ3_DANRE/28-213 AC A0A8M3ANJ3.1
#=GS G7YAP5_CLOSI/1-70 AC G7YAP5.1
#=GS A0A6J1HP01_CUCMA/61-224 AC A0A6J1HP01.1
#=GS A0A8S1W4H8_9CILI/6-191 AC A0A8S1W4H8.1
#=GS A0A016WA43_9BILA/1-167 AC A0A016WA43.1
#=GS A0A7N5JGW6_AILME/8-184 AC A0A7N5JGW6.1
#=GS A0A4W5QCW1_9TELE/6-198 AC A0A4W5QCW1.1
#=GS A0A212EJV0_DANPL/11-187 AC A0A212EJV0.1
#=GS G5B9N3_HETGA/27-218 AC G5B9N3.1
#=GS A0A3N0Z4R6_ANAGA/19-216 AC A0A3N0Z4R6.1
#=GS A0A369GIS2_9HYPO/2-188 AC A0A369GIS2.1
#=GS A0A8H6L617_9LECA/58-235 AC A0A8H6L617.1
#=GS A0A2K5LVS5_CERAT/28-213 AC A0A2K5LVS5.1
#=GS A0A9J7LQT6_BRAFL/1-176 AC A0A9J7LQT6.1
#=GS A0A7K5YGY3_9AVES/3-151 AC A0A7K5YGY3.1
#=GS A0A7N8XWG7_9TELE/28-214 AC A0A7N8XWG7.1
#=GS A0A0D2GWX5_9EURO/169-351 AC A0A0D2GWX5.1
#=GS A0A6J1Z517_ACIJB/1-170 AC A0A6J1Z517.1
#=GS W5JZD6_ASTMX/7-183 AC W5JZD6.2
#=GS A0A0D2E9R1_9EURO/2-174 AC A0A0D2E9R1.1
#=GS A0A8B8YEN1_BALMU/8-184 AC A0A8B8YEN1.1
#=GS W5M5G1_LEPOC/3-166 AC W5M5G1.1
#=GS A0A851TVY7_9PASS/6-207 AC A0A851TVY7.1
#=GS A0A8J8W641_9EURO/163-347 AC A0A8J8W641.1
#=GS A0A0E0Q0A4_ORYRU/8-212 AC A0A0E0Q0A4.1
#=GS A0A8E0QXE9_9EURO/43-117 AC A0A8E0QXE9.1
#=GS M2MIX1_BAUPA/48-238 AC M2MIX1.1
#=GS A0A1L9SIK0_9EURO/166-354 AC A0A1L9SIK0.1
#=GS F4SB14_MELLP/1-145 AC F4SB14.1
#=GS G3WLX2_SARHA/8-184 AC G3WLX2.2
#=GS A0A059LD93_9CHLO/23-142 AC A0A059LD93.1
#=GS A0A5F8HFK3_MONDO/8-71 AC A0A5F8HFK3.1
#=GS A0A7E6F1C9_OCTVU/6-209 AC A0A7E6F1C9.1
#=GS A0A6A5DZ81_PERFL/1-173 AC A0A6A5DZ81.1
#=GS A0A2K6CAX9_MACNE/8-184 AC A0A2K6CAX9.1
#=GS A0A0F0I2B0_ASPPU/171-358 AC A0A0F0I2B0.1
#=GS A0A8J1JCK7_XENTR/1-75 AC A0A8J1JCK7.1
#=GS A0A179GBN0_PURLI/1-186 AC A0A179GBN0.1
#=GS A0A5N6NNB1_9ASTR/86-256 AC A0A5N6NNB1.1
#=GS A0A8C8SXN7_9SAUR/1-166 AC A0A8C8SXN7.1
#=GS A0A8C5ASH3_GADMO/17-215 AC A0A8C5ASH3.1
#=GS A0A830C1P9_9LAMI/1-150 AC A0A830C1P9.1
#=GS A0A1J9RBY4_9PEZI/2-175 AC A0A1J9RBY4.1
#=GS A0A0V0TIQ8_9BILA/84-280 AC A0A0V0TIQ8.1
#=GS A0A671X634_SPAAU/1-151 AC A0A671X634.1
#=GS A0A667YIJ9_9TELE/7-183 AC A0A667YIJ9.1
#=GS A0A6Q2YMY3_ESOLU/3-197 AC A0A6Q2YMY3.1
#=GS A0A6J1QDQ9_9HYME/9-94 AC A0A6J1QDQ9.1
#=GS A0A8T2J5A3_9PIPI/11-189 AC A0A8T2J5A3.1
#=GS A0A341AQZ0_NEOAA/8-184 AC A0A341AQZ0.1
#=GS A0A7K5XWU0_9CHAR/3-151 AC A0A7K5XWU0.1
#=GS A0A9D3VX53_9ROSI/11-202 AC A0A9D3VX53.1
#=GS A0A1W0A409_9STRA/13-199 AC A0A1W0A409.1
#=GS A0A665WHY8_ECHNA/28-213 AC A0A665WHY8.1
#=GS A0A319F7Z9_ASPSB/2-175 AC A0A319F7Z9.1
#=GS A0A850TDC2_GRUAM/3-151 AC A0A850TDC2.1
#=GS A0A0D0VD20_9TREE/191-380 AC A0A0D0VD20.1
#=GS A0A6P9AJF6_PANGU/8-184 AC A0A6P9AJF6.1
#=GS A0A8C9U599_SERCA/1-165 AC A0A8C9U599.1
#=GS A0A5F9CXU5_RABIT/28-188 AC A0A5F9CXU5.1
#=GS A0A1R2BMX5_9CILI/1-160 AC A0A1R2BMX5.1
#=GS A0A7K4K9D0_9AVES/28-213 AC A0A7K4K9D0.1
#=GS A0A158PQ46_BRUPA/13-203 AC A0A158PQ46.1
#=GS A0A8C5WI18_9ANUR/8-185 AC A0A8C5WI18.1
#=GS A0A2B7ZFQ3_9EURO/2-176 AC A0A2B7ZFQ3.1
#=GS A0A6Q2XB37_ESOLU/11-187 AC A0A6Q2XB37.1
#=GS A0A8X8XG77_SALSN/230-421 AC A0A8X8XG77.1
#=GS A0A8C2TJZ7_COTJA/28-213 AC A0A8C2TJZ7.1
#=GS A0A397J037_9GLOM/1-176 AC A0A397J037.1
#=GS A0A093HIS0_STRCA/2-161 AC A0A093HIS0.1
#=GS A0A8H5TG97_FUSHE/2-175 AC A0A8H5TG97.1
#=GS A0A151IVS5_9HYME/7-203 AC A0A151IVS5.1
#=GS A0A8S0T1L9_OLEEU/1-71 AC A0A8S0T1L9.1
#=GS A0A667GG98_LYNCA/8-58 AC A0A667GG98.1
#=GS A0A8H6QPT1_9EURO/168-357 AC A0A8H6QPT1.1
#=GS A0A8C4V0U6_FALTI/1-172 AC A0A8C4V0U6.1
#=GS A0A1E3QQQ2_9ASCO/177-368 AC A0A1E3QQQ2.1
#=GS A0A6J3LMF6_9HYME/3-169 AC A0A6J3LMF6.1
#=GS A0A7J7QPU5_9CHLO/4-195 AC A0A7J7QPU5.1
#=GS A0A8H4VVW6_9AGAR/1-175 AC A0A8H4VVW6.1
#=GS W5NK40_LEPOC/7-183 AC W5NK40.1
#=GS A0A914UHJ8_9BILA/60-254 AC A0A914UHJ8.1
#=GS A0A8J5FNP1_ZINOF/89-257 AC A0A8J5FNP1.1
#=GS A0A6I9LLL2_PERMB/1-172 AC A0A6I9LLL2.1
#=GS A0A1Y2DRE5_9PEZI/2-175 AC A0A1Y2DRE5.1
#=GS R8BX10_PHAM7/2-182 AC R8BX10.1
#=GS A0A094CCI7_9PEZI/1-175 AC A0A094CCI7.1
#=GS A0A3M2RZ06_9HYPO/1-187 AC A0A3M2RZ06.1
#=GS A0A7M5XLX2_9CNID/4-182 AC A0A7M5XLX2.1
#=GS A0A835W395_9CHLO/2-193 AC A0A835W395.1
#=GS A0A6A3BY40_HIBSY/5-214 AC A0A6A3BY40.1
#=GS A0A8B9N8R2_9AVES/28-109 AC A0A8B9N8R2.1
#=GS A0A8C4DGP6_DICLA/6-202 AC A0A8C4DGP6.2
#=GS A0A0V0V293_9BILA/84-280 AC A0A0V0V293.1
#=GS A0A068V1E2_COFCA/17-213 AC A0A068V1E2.1
#=GS A0A6P8FC69_CLUHA/7-183 AC A0A6P8FC69.1
#=GS A0A7J6EFE2_CANSA/1-173 AC A0A7J6EFE2.1
#=GS A0A443SSC9_9ACAR/23-222 AC A0A443SSC9.1
#=GS D7MD11_ARALL/12-201 AC D7MD11.1
#=GS A0A7K8WVB3_9FURN/1-172 AC A0A7K8WVB3.1
#=GS A0A672PKW7_SINGR/34-226 AC A0A672PKW7.1
#=GS A0A8C3G459_CYCLU/4-203 AC A0A8C3G459.1
#=GS A1CDQ5_ASPCL/168-356 AC A1CDQ5.1
#=GS A0A0V0Y8M8_TRIPS/14-210 AC A0A0V0Y8M8.1
#=GS A0A8D2GZC3_UROPR/1-172 AC A0A8D2GZC3.1
#=GS A0A0D3BWJ0_BRAOL/5-208 AC A0A0D3BWJ0.1
#=GS A0A5C3DRY0_9BASI/1-180 AC A0A5C3DRY0.1
#=GS A0A813RCM6_9BILA/11-186 AC A0A813RCM6.1
#=GS A0A9J6BYH3_POLVA/12-185 AC A0A9J6BYH3.1
#=GS A0A5N5NGT6_PANHP/8-184 AC A0A5N5NGT6.1
#=GS A0A8D0CBI2_SALMN/8-184 AC A0A8D0CBI2.1
#=GS A0A673LZS2_9TELE/3-193 AC A0A673LZS2.1
#=GS A0A8C5ACH8_GADMO/11-187 AC A0A8C5ACH8.1
#=GS A0A8D2P129_ZOSLA/1-138 AC A0A8D2P129.1
#=GS A0A1V1SZZ3_9PEZI/2-175 AC A0A1V1SZZ3.1
#=GS A0A0P0VVF6_ORYSJ/1-200 AC A0A0P0VVF6.1
#=GS A0A673LFC8_9TELE/11-151 AC A0A673LFC8.1
#=GS A0A484L3J3_9ASTE/1-172 AC A0A484L3J3.1
#=GS A0A0V1HU22_9BILA/10-189 AC A0A0V1HU22.1
#=GS M4EXL8_BRACM/11-200 AC M4EXL8.1
#=GS A0A8C8A5W6_9STRI/1-174 AC A0A8C8A5W6.1
#=GS A0A2Y9L538_ENHLU/8-184 AC A0A2Y9L538.1
#=GS A0A8J5YE86_9ROSI/104-266 AC A0A8J5YE86.1
#=GS A0A251L830_MANES/58-248 AC A0A251L830.1
#=GS A0A7J6U1N3_PEROL/1-86 AC A0A7J6U1N3.1
#=GS A0A0D2NCF4_HYPSF/1-175 AC A0A0D2NCF4.1
#=GS A0A067EDQ3_CITSI/1-173 AC A0A067EDQ3.1
#=GS A0A4Q4V7S6_9PEZI/4-187 AC A0A4Q4V7S6.1
#=GS A0A8C7J7H3_ONCKI/17-215 AC A0A8C7J7H3.1
#=GS A0A6J0SGV5_9SAUR/1-175 AC A0A6J0SGV5.1
#=GS G3AZT7_CANTC/2-175 AC G3AZT7.1
#=GS A0A0M9VX24_9HYPO/2-175 AC A0A0M9VX24.1
#=GS A0A673BW58_9TELE/6-201 AC A0A673BW58.1
#=GS A0A8X8XTN4_SALSN/1-174 AC A0A8X8XTN4.1
#=GS A0A9R1SNT3_CYPCA/8-209 AC A0A9R1SNT3.1
#=GS A0A669BMF2_ORENI/18-217 AC A0A669BMF2.1
#=GS A0A1S2YWA8_CICAR/5-215 AC A0A1S2YWA8.1
#=GS A0A8D0BDN7_SALMN/9-207 AC A0A8D0BDN7.1
#=GS A0A0R3WIJ5_HYDTA/40-242 AC A0A0R3WIJ5.2
#=GS A0A8H5GNP6_9AGAR/1-191 AC A0A8H5GNP6.1
#=GS C1EDJ4_MICCC/39-201 AC C1EDJ4.1
#=GS A0A2N1JAT6_9BASI/175-362 AC A0A2N1JAT6.1
#=GS A0A7J9D8J6_9ROSI/96-254 AC A0A7J9D8J6.1
#=GS A0A6P6MA34_CARAU/28-211 AC A0A6P6MA34.1
#=GS A0A7L2EM42_ANTMN/2-200 AC A0A7L2EM42.1
#=GS A0A8B6C7G7_MYTGA/9-207 AC A0A8B6C7G7.1
#=GS A0A674F2G9_SALTR/27-212 AC A0A674F2G9.1
#=GS A0A8C0KV41_CANLU/3-93 AC A0A8C0KV41.1
#=GS A0A670JRF3_PODMU/8-184 AC A0A670JRF3.1
#=GS A0A8C2ZSL9_CYCLU/8-207 AC A0A8C2ZSL9.1
#=GS A0A074XSS0_AURPU/108-295 AC A0A074XSS0.1
#=GS A0A6P5BTA6_BOSIN/8-184 AC A0A6P5BTA6.1
#=GS A0A0V1HWH6_9BILA/363-542 AC A0A0V1HWH6.1
#=GS A0A9J7X369_CYPCA/28-213 AC A0A9J7X369.1
#=GS A0A0W8DK42_PHYNI/137-242 AC A0A0W8DK42.1
#=GS A0A395HLB5_ASPHC/166-354 AC A0A395HLB5.1
#=GS A0A5J9VGV5_9POAL/1-173 AC A0A5J9VGV5.1
#=GS A0A6A5FF80_PERFL/7-183 AC A0A6A5FF80.1
#=GS A0A1B6QEZ9_SORBI/8-202 AC A0A1B6QEZ9.1
#=GS A0A7L2YH94_JACJC/1-172 AC A0A7L2YH94.1
#=GS A0A9J7XCS3_CYPCA/28-211 AC A0A9J7XCS3.1
#=GS A0A914NE75_MELIC/2-202 AC A0A914NE75.1
#=GS A0A0A1UH95_ENTIV/2-170 AC A0A0A1UH95.1
#=GS E2A2V3_CAMFO/22-212 AC E2A2V3.1
#=GS A0A177TSE8_9BASI/1-179 AC A0A177TSE8.1
#=GS A0A2R6XT48_MARPO/106-261 AC A0A2R6XT48.1
#=GS A0A7K8P1N6_COCCO/8-184 AC A0A7K8P1N6.1
#=GS M3WJQ1_FELCA/1-170 AC M3WJQ1.3
#=GS A0A453SJP1_AEGTS/1-124 AC A0A453SJP1.1
#=GS A0A8C3HWV4_CHRPI/1-142 AC A0A8C3HWV4.1
#=GS A0A0L8HB99_OCTBM/6-209 AC A0A0L8HB99.1
#=GS A0A8C6UWP4_9GOBI/2-152 AC A0A8C6UWP4.1
#=GS A0A0D3GSH2_9ORYZ/10-165 AC A0A0D3GSH2.1
#=GS A0A444XM15_ARAHY/1-173 AC A0A444XM15.1
#=GS L5LMK9_MYODS/37-120 AC L5LMK9.1
#=GS A0A6J3LP98_9HYME/11-184 AC A0A6J3LP98.1
#=GS A0A7J8HGE2_MOLMO/48-245 AC A0A7J8HGE2.1
#=GS A0A8C8YMN8_PROSS/5-194 AC A0A8C8YMN8.1
#=GS A0A7K5K210_9TYRA/2-200 AC A0A7K5K210.1
#=GS A0A7L3T3I8_RISTR/28-213 AC A0A7L3T3I8.1
#=GS A0A1P8BHE1_ARATH/1-172 AC A0A1P8BHE1.1
#=GS A0A409VZV9_9AGAR/8-160 AC A0A409VZV9.1
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