Entry
Name
aminoglycoside 3-N-acetyltransferase;
3-aminoglycoside acetyltransferase;
3-N-aminoglycoside acetyltransferase;
aminoglycoside N3-acetyltransferase;
acetyl-CoA:2-deoxystreptamine-antibiotic N3'-acetyltransferase (incorrect);
aminoglycoside N3'-acetyltransferase (incorrect)
Class
Transferases;
Acyltransferases;
Transferring groups other than aminoacyl groups
BRITE hierarchy
Sysname
acetyl-CoA:2-deoxystreptamine-antibiotic N3-acetyltransferase
Reaction(IUBMB)
acetyl-CoA + a 2-deoxystreptamine antibiotic = CoA + N3-acetyl-2-deoxystreptamine antibiotic [RN:
R04348 ]
Reaction(KEGG)
Substrate
acetyl-CoA [CPD:
C00024 ];
2-deoxystreptamine antibiotic [CPD:
C03922 ]
Product
CoA [CPD:
C00010 ];
N3-acetyl-2-deoxystreptamine antibiotic [CPD:
C04504 ]
Comment
Different from EC
2.3.1.60 gentamicin 3-N-acetyltransferase. A wide range of antibiotics containing the 2-deoxystreptamine ring can act as acceptors, including gentamicin, kanamycin, tobramycin, neomycin and apramycin.
History
EC 2.3.1.81 created 1984, modified 2015
Orthology
K00662 aminoglycoside 3-N-acetyltransferase
K19275 aminoglycoside 3-N-acetyltransferase II
K19276 aminoglycoside 3-N-acetyltransferase IV
K19277 aminoglycoside 3-N-acetyltransferase VI
Genes
ECV : APECO1_O1R90(aac3-VI)
SEE : SNSL254_p_0145(aacC)
KOE : A225_1935 A225_R1p0530
KPAS : LUW96_29510(aac(3)-IId)
CFAR : CI104_19135 CI104_26755
PVJ : LMA04_22195(aac(3)-IIg)
APOT : MZO21_13000(aac(3)-IId)
SHEJ : MZ182_20510(aac(3)-IId) MZ182_20675(aac(3)-IId)
LLG : 44548918_00186(yokD)
RHEI : ATY27_04040 ATY27_12900
CCAX : KZ686_03840(aac(3)-IVb)
AXX : ERS451415_00991(yokD)
MENY : LSQ66_17255(aac(3))
SMI : BN406_02113(aacC4) BN406_03656(aacC3)
SMEL : SM2011_c02813(aacC)
ECAA : J3R84_29495(aac(3))
REC : RHECIAT_CH0001181(aacC)
REL : REMIM1_CH01107(aacC)
REP : IE4803_CH01119(aacC)
REI : IE4771_CH01171(aacC)
RPHA : AMC79_CH01119(aacC)
RBAN : J2J98_05330(aac(3))
RLW : RlegWSM1455_03960(aac(3)) RlegWSM1455_04065(aac(3))
BVES : QO058_28325(aac(3))
MICO : GDR74_11075(aac(3))
RPOP : K1718_24850 K1718_24890
SPHF : DM480_17860(aac(3))
SNOS : K8P63_04750(aac(3))
SPHS : ETR14_01485(aac(3))
SKT : IGS68_02455(aac(3)) IGS68_22170
SROE : JL101_022510 JL101_022995(aac(3))
MAGQ : MGMAQ_1145 MGMAQ_3711
CJB : BN148_1297 BN148_1298
CJP : A911_06295 A911_06305
CJEJ : N564_01316 N564_02215
CJEU : N565_01353 N565_02305
CJEN : N755_01348 N755_02360
CJEI : N135_01386 N135_02210
CJY : QZ67_01431 QZ67_01432
CJW : PJ18_06680 PJ18_06685
CJZ : M635_02170 M635_02175
CPEL : CPEL_1413 CPEL_1416 CPEL_1421
CSM : CSUB8521_0847 CSUB8521_1490
CSF : CSUB8523_0934 CSUB8523_1586
CPIN : CPIN18020_0009 CPIN18020_0987 CPIN18020_1617 CPIN18020_1621 CPIN18020_1624
CARM : CARM_0874 CARM_1308 CARM_1337
CMUC : CMCT_0408 CMCT_0585
CINF : CINF_0140 CINF_0203 CINF_0835
CFUS : CYFUS_000170 CYFUS_003309
SCU : SCE1572_01630 SCE1572_29530
NANN : O0S08_25295(aac(3))
MTAR : DF168_00395(yokD_1) DF168_01796(yokD_2)
TALB : FTW19_01550(aac(3))
MSEA : METESE_36250(aacC) METESE_36440
SPIB : G8759_34445(aac(3))
SENF : GJR95_04155(aac(3))
PROW : OO006_09575(aac(3))
PROI : OO005_08825(aac(3))
BCR : BCAH187_A2976(aacC7)
BCB : BCB4264_A2939(aacC7)
BCG : BCG9842_B2306(aacC7)
BCOH : BC6307_06970 BC6307_07895
BMQ : BMQ_3091 BMQ_pBM70161
HSAN : MUN89_01735 MUN89_11385
BLEN : NCTC4824_00505(yokD_1) NCTC4824_01263(yokD_2)
LGZ : NCTC10812_01143(yokD)
GHA : NCTC10459_01370(yokD)
PJD : Pjdr2_3266 Pjdr2_6143
GYM : GYMC10_5436 GYMC10_6252
PMS : KNP414_01652 KNP414_04467 KNP414_07856
PMQ : PM3016_1956 PM3016_3885 PM3016_7374
PMW : B2K_09920 B2K_20230 B2K_37215
PTA : HPL003_01270 HPL003_06965
PSAB : PSAB_01805 PSAB_02530
PBD : PBOR_02420 PBOR_05360 PBOR_23060
PGM : PGRAT_02680 PGRAT_05450 PGRAT_31510
PAEN : P40081_02695 P40081_05645 P40081_23445
PAEF : R50345_02280 R50345_04450
PAEQ : R50912_02440 R50912_04965 R50912_21660
PSTE : PSTEL_02535 PSTEL_26335
PAEA : R70723_02060 R70723_04470 R70723_18945
PAEE : R70331_02000 R70331_04480
PAEH : H70357_02305 H70357_04895 H70357_05180
PAEJ : H70737_02365 H70737_04710
PBJ : VN24_06600 VN24_16780
PRI : PRIO_0581(yokD) PRIO_1155 PRIO_6585
PSON : JI735_07605 JI735_11350 JI735_13955
PDH : B9T62_06735 B9T62_37935
PIB : BBD41_14815 BBD41_18970
PCX : LPB68_03185 LPB68_06950 LPB68_19250
PVO : PVOR_01330 PVOR_29359
PLW : D5F53_02890 D5F53_30495
PLEN : EIM92_05550 EIM92_05555 EIM92_09560
PLUT : EI981_02125 EI981_06240 EI981_28435
PTRI : KDC22_02360 KDC22_04695
PCEL : HUB94_17405 HUB94_26855
PTJ : JRJ22_03670 JRJ22_03875
PDY : QJQ58_23810 QJQ58_30000
PWN : QNH46_19070 QNH46_23285
PSPN : L1F29_26235 L1F29_33325
PPOG : QPK24_13015 QPK24_19770
PGLU : A3958_04820 A3958_08890
COHL : J4772_05610 J4772_35740
FPEN : KIW23_03455 KIW23_05985
LJE : BUE77_04485 BUE77_05600
LMUL : PUW59_03460 PUW59_04625
LKO : ABN16_06140 ABN16_13135
VHY : G7082_07420 G7082_08595
OCW : OW730_17880 OW730_25680
ACHT : bsdcttw_44970(yokD)
KIB : RBB56_07915 RBB56_08630
CLE : Clole_1318 Clole_3275
CEW : EKH84_09170 EKH84_19310
CBAR : PATL70BA_2969(aacD)
VGU : HYG85_00340 HYG85_18135
HALS : D7D81_09980 D7D81_17820
IFN : GM661_07330 GM661_14480
APAL : BN85407420 BN85409210
AAXA : NCTC10138_01478(yokD)
SANL : KZO11_03855 KZO11_37135(aac(3))
SGRF : SGFS_079920 SGFS_087390
SCB : SCAB_63431 SCAB_70011
STRP : F750_1064 F750_2696
SAMB : SAM23877_1998(yokD)
SPRI : SPRI_3493 SPRI_5791
SLS : SLINC_2223 SLINC_2807
SGE : DWG14_04341(yokD_1) DWG14_06455(yokD_2)
SDX : C4B68_27540 C4B68_30780
SAQU : EJC51_12840 EJC51_38855
SPHV : F9278_09720 F9278_44385
SCHA : CP983_30465 CP983_32935
SSPB : CP982_11285 CP982_13030(aac(3))
SHUN : DWB77_05814(yokD_1) DWB77_05989(yokD_2) DWB77_07277(yokD_3)
SLIA : HA039_01765 HA039_27280
SFB : CP974_27300(aac(3)-VIII)
SXN : IAG42_27305 IAG42_30545(aac(3))
SDEC : L3078_11235 L3078_14550 L3078_29905
SDUR : M4V62_14505(aac(3)) M4V62_31765
SAKB : K1J60_31000 K1J60_34305
SCAE : IHE65_31035 IHE65_34410
SXT : KPP03845_101974(yokD)
SCOA : QU709_30090 QU709_33395
STRL : HEP84_15320 HEP84_53115
STSD : HEP87_15420 HEP87_26405 HEP87_53310
SRPZ : HEP85_10720 HEP85_43780
SGLY : P8A20_22595(aac(3)) P8A20_32260
KCH : O1G21_17360 O1G21_33085
SANW : G7063_00200 G7063_00405
AMAZ : LUW76_21760(aac(3))
SPIQ : OHA34_17075(aac(3))
PSDS : K1T35_44520(aac(3))
MAU : Micau_4767 Micau_5995
MICB : MicB006_3781 MicB006_6125
MTUA : CSH63_00700 CSH63_05335 CSH63_27015
VMA : VAB18032_17990 VAB18032_21790
MCHL : PVK74_14060 PVK74_20185
ASE : ACPL_1492(yokD) ACPL_3641(yokD)
AMS : AMIS_23580 AMIS_27610
ACTS : ACWT_1371 ACWT_3513
ASIC : Q0Z83_017120 Q0Z83_031300
PLK : CIK06_07880 CIK06_21920
PRY : Prubr_07890 Prubr_19890 Prubr_64310
DACT : KZZ52_05195 KZZ52_58230
AMR : AM1_3129(aacC) AM1_A0084(aacC3) AM1_B0404(aacC3)
GML : ISF26_18000(aac(3)-IV)
ABAT : CFX1CAM_0092 CFX1CAM_0121
DPD : Deipe_0300 Deipe_1224
DSW : QR90_00265 QR90_07605
DCH : SY84_05795 SY84_14340
DAB : AUC44_05725 AUC44_13140
DWU : DVJ83_01195 DVJ83_08220
DEIN : DAAJ005_04045 DAAJ005_13770
DGA : DEGR_10810 DEGR_25580
DMB : E5F05_14195 E5F05_16615
DSC : ABOD76_04595 ABOD76_14180
MINF : MESINF_0461(yokD) MESINF_1071
LOKI : Lokiarch_04250(yokD_1) Lokiarch_53270(yokD_2)
» show all
Taxonomy
Reference
Authors
Davies J, O'Connor S.
Title
Enzymatic modification of aminoglycoside antibiotics: 3-N-acetyltransferase with broad specificity that determines resistance to the novel aminoglycoside apramycin.
Journal
Other DBs
ExplorEnz - The Enzyme Database: 2.3.1.81
ExPASy - ENZYME nomenclature database: 2.3.1.81