KEGG ENZYME: 2.3.1.263

ENZYME: 2.3.1.263

Entry

EC 2.3.1.263                Enzyme

Name

2-amino-4-oxopentanoate thiolase;
AKPT;
AKP thiolase;
2-amino-4-ketopentanoate thiolase

Class

Transferases;
Acyltransferases;
Transferring groups other than aminoacyl groups

Sysname

acetyl-CoA:D-alanine acetyltransferase

Reaction(IUBMB)

acetyl-CoA + D-alanine = CoA + (2R)-2-amino-4-oxopentanoate [RN:R00399]

Reaction(KEGG)

R00399

Substrate

acetyl-CoA [CPD:C00024];
D-alanine [CPD:C00133]

Product

CoA [CPD:C00010];
(2R)-2-amino-4-oxopentanoate [CPD:C03341]

Comment

A pyridoxal 5'-phosphate enzyme. The enzyme, characterized from the bacterium Clostridium sticklandii, is part of a degradation pathway of ornithine. It is specific for acetyl-CoA and D-alanine.

History

EC 2.3.1.263 created 2017

Orthology

K21399

2-amino-4-ketopentanoate thiolase alpha subunit

K21400

2-amino-4-ketopentanoate thiolase beta subunit

Genes

MECH:

Q9L42_012455(ortA) Q9L42_012460(ortB)

CEH:	CEW89_15605 CEW89_15610

PBAE:

P8S53_16570(ortA) P8S53_16575(ortB)

TPI:	TREPR_1362 TREPR_1363

SLR:	L21SP2_1010 L21SP2_1011

MSIL:

METEAL_10830(ortB) METEAL_10840 METEAL_38100

MSEA:

METESE_34610

BACI:

B1NLA3E_09765 B1NLA3E_09770

OCN:	CUC15_16345 CUC15_16350

OCB:	CV093_17505

VIK:	KFZ58_15035 KFZ58_15040

EAV:	EH197_05055 EH197_05060

VCP:	H9L18_06405 H9L18_06410

VHY:	G7082_14525 G7082_14530

FCT:	NRE15_11420(ortA) NRE15_11425(ortB)

CSQ:	CSCA_0121 CSCA_0122

CACE:

CACET_c17490 CACET_c17500

CEU:	A7L45_16585 A7L45_16590

CFM:	BJL90_14520 BJL90_14525

CARG:

RSJ17_08680 RSJ17_08685

CDRK:

B9W14_17930 B9W14_17935

CFER:

D4Z93_10560

CLOS:

DMR38_05800

CTAG:

LL095_13675 LL095_13680

CALE:

FDN13_03010 FDN13_03015

CALD:

PWK10_08610(ortB)

CRS:	FQB35_06690 FQB35_06695

CPRF:

K7H06_08995 K7H06_09000

CRAS:

KVH43_11405 KVH43_11410

OCW:	OW730_12715(ortA) OW730_12720(ortB)

PROQ:

P6M73_15850(ortB) P6M73_15855(ortA)

FPLA:

A4U99_15100 A4U99_15105

PETR:

QKW49_11295(ortB) QKW49_11300(ortA)

DAI:	Desaci_1874 Desaci_1875

AACX:

DEACI_0847 DEACI_0848

ACAE:

HYG86_08065 HYG86_08070

PROM:

QO263_13845(ortB) QO263_13850(ortA)

EUU:	ADJ67_00770 ADJ67_00775

CHYL:

CE91St63_01880(ortB) CE91St63_01890

VGU:	HYG85_19055 HYG85_19060

VPY:	HZI73_17670 HZI73_17675

AMIJ:

EQM06_08565 EQM06_08570 EQM06_12590 EQM06_12595

AMIC:

Ami3637_07695 Ami3637_07700

ABUT:

Ami103574_00585 Ami103574_00590

ETM:	CE91St48_00560(ortA_1) CE91St48_00570(ortB_1) CE91St48_06030(ortA_2) CE91St48_06040(ortB_2) CE91St48_06120 CE91St48_06130(ortB_3) CE91St48_34270(ortB_4) CE91St48_34280(ortA_3) CE91St48_39720(ortB_5) CE91St48_39730(ortA_4) CE91St48_40600(ortB_6) CE91St48_40610(ortA_5)

EMJ:	V1225_02255(ortB) V1225_02260(ortA) V1225_04130(ortA) V1225_04135(ortB)

AMT:	Amet_0508 Amet_0509 Amet_2368 Amet_2369

AOE:	Clos_1697 Clos_1698 Clos_2823 Clos_2824

GFE:	Gferi_19575 Gferi_19580 Gferi_26735 Gferi_26740

CSPO:

QNI18_08930(ortA) QNI18_08935(ortB)

CDF:	CD630_04430(ortA) CD630_04440(ortB)

PDC:	CDIF630_00571(ortA) CDIF630_00572(ortB)

CDC:	CD196_0400 CD196_0401

CDL:	CDR20291_0386 CDR20291_0387

PDF:	CD630DERM_04430(ortA) CD630DERM_04440(ortB)

RHOM:

FRIFI_0795 FRIFI_0796

TEM:	JW646_03940 JW646_03945 JW646_04415 JW646_04420

TGC:	L0P85_03855(ortA) L0P85_04330(ortA)

TMY:	TEMA_39470(ortA_1) TEMA_39480(ortB_1) TEMA_40300(ortA_2) TEMA_40310(ortB_2)

TPET:

TPHSE_09830(ortA_1) TPHSE_09840(ortB_1) TPHSE_10700(ortA_2) TPHSE_10710(ortB_2)

TEB:	T8CH_0874(ortA) T8CH_0875(ortB)

THYR:

P4S50_12695(ortB) P4S50_12700(ortA)

CST:	CLOST_1292(ortB) CLOST_1293(ortA)

TTE:	TTE1235 TTE1236(ThrC)

TEX:	Teth514_1478 Teth514_1479

THX:	Thet_1424 Thet_1425

TPD:	Teth39_1041 Teth39_1042

TBO:	Thebr_1068 Thebr_1069

TWI:	Thewi_1185 Thewi_1186

THEZ:

OEI98_001236(ortA) OEI98_001237(ortB)

TOC:	Toce_1487 Toce_1488

NTH:	Nther_1167 Nther_1168

NCD:	ACONDI_02428(ortB) ACONDI_02429(ortA)

HOR:	Hore_21100 Hore_21110

AFT:	BBF96_13565 BBF96_13570

KME:	H0A61_00509(ortB) H0A61_00510(ortA)

HPRF:

HLPR_14370(ortB) HLPR_14380(ortA)

SPOA:

EQM13_10955 EQM13_10960

KPAR:

JL105_07130 JL105_07135

CAZO:

G3A45_03835 G3A45_03840

TIZ:	RBU61_10270(ortB) RBU61_10275(ortA)

SEDZ:

JYG23_00915 JYG23_00920

SEDM:

RBQ61_03970(ortA) RBQ61_03975(ortB) RBQ61_08930(ortA) RBQ61_08935(ortB)

PFT:	JBW_01653 JBW_01654

SSID:

SPSIL_044620(ortB) SPSIL_044630(ortA)

SACV:

SPACI_032230(ortB) SPACI_032240(ortA)

FCZ:	IMF26_05975 IMF26_05980

MANR:

MPAN_008570 MPAN_008580(ortB)

XCL:	G4Z02_05180 G4Z02_05185

TBK:	HF295_00040 HF295_00045

MBJ:	KQ51_00245(trpB_1) KQ51_00246

TBM:	BK010_05550 BK010_05555

TBZ:	BK011_05590 BK011_05595

ARS:	ADJ73_08365 ADJ73_08370

PAC:	PPA2277 PPA2278

PAK:	HMPREF0675_5354 HMPREF0675_5355

PAV:	TIA2EST22_11165 TIA2EST22_11170

PAX:	TIA2EST36_11140 TIA2EST36_11145

PAZ:	TIA2EST2_11085 TIA2EST2_11090

PAW:	PAZ_c23750 PAZ_c23760

PAD:	TIIST44_04205 TIIST44_04210

PCN:	TIB1ST10_11605 TIB1ST10_11610

PACC:

PAC1_11615 PAC1_11620

PACH:

PAGK_2186 PAGK_2187

PACN:

TIA1EST1_11235 TIA1EST1_11240

CACN:

RN83_00015 RN83_00020

PRA:	PALO_10900

PRL:	BCB70_06950 BCB70_06955

CGRN:

4412665_01729 4412665_01730(trpB_2)

CEQU:

O6R08_10895(ortA) O6R08_10900(ortB)

PAUS:

NCTC13651_02410(trpB_3) NCTC13651_02411

PPC:	HMPREF9154_0893 HMPREF9154_0894

ARUB:

J5A65_10525 J5A65_10530

PROP:

QQ658_14540(ortA) QQ658_14545(ortB)

ABAT:

CFX1CAM_0746 CFX1CAM_0747

ACO:	Amico_1693 Amico_1694

AMIZ:

RBH88_00905(ortB) RBH88_00910(ortA)

TLI:	Tlie_1696 Tlie_1697

TME:	Tmel_0906 Tmel_0907

TAF:	THA_1161 THA_1162

THP:	BG95_05270

THER:

Y592_05350 Y592_05355

TFE:	JYK00_04205 JYK00_04210

FNO:	Fnod_1644 Fnod_1645

FPE:	Ferpe_1991 Ferpe_1992

FIA:	NA23_09980(ortA) NA23_09985(ortB)

FRR:	IB67_00420 IB67_00425

OCY:	OSSY52_03910(ortA) OSSY52_03920(ortB)

PMO:	Pmob_1167 Pmob_1168

MPZ:	Marpi_1534 Marpi_1535

MARN:

LN42_08175 LN42_08180

MAEO:

JRV97_04085 JRV97_04090

DTN:	DTL3_0760 DTL3_0761

OCS:	OF820_08005(ortB) OF820_08010(ortA)

KOL:	Kole_0357 Kole_0358

KPF:	IX53_10195 IX53_10200

MPG:	Theba_1252 Theba_1253

MINF:

MESINF_2282 MESINF_2283

ASAC:

ATHSA_0995 ATHSA_0996

FHW:	RN87_08670 RN87_08675

FPD:	CTM68_09150 CTM68_09155

FCI:	I6I83_05755 I6I83_05760

MTHM:

FZP57_08790

» show all

Reference

1 [PMID:4407783]

Authors

Jeng IM, Somack R, Barker HA

Title

Ornithine degradation in Clostridium sticklandii; pyridoxal phosphate and coenzyme A dependent thiolytic cleavage of 2-amino-4-ketopentanoate to alanine and acetyl coenzyme A.

Journal

Biochemistry 13:2898-903 (1974)
DOI:10.1021/bi00711a019

Reference

2 [PMID:19251850]

Authors

Fonknechten N, Perret A, Perchat N, Tricot S, Lechaplais C, Vallenet D, Vergne C, Zaparucha A, Le Paslier D, Weissenbach J, Salanoubat M

Title

A conserved gene cluster rules anaerobic oxidative degradation of L-ornithine.

Journal

J Bacteriol 191:3162-7 (2009)
DOI:10.1128/JB.01777-08

Sequence

[ag:CAQ42979 CAQ42980]