Distinguishing severe asthma phenotypes

Presentation on theme: "Distinguishing severe asthma phenotypes"— Presentation transcript:

1 Distinguishing severe asthma phenotypes
Christina Miranda, MS, PA-C, Ashley Busacker, BS, Silvana Balzar, MD, John Trudeau, BS, Sally E. Wenzel, MD  Journal of Allergy and Clinical Immunology  Volume 113, Issue 1, Pages (January 2004) DOI: /j.jaci

2 FIG 1 Allergic symptoms and allergen sensitization are higher in subjects with early-onset versus late-onset disease. Journal of Allergy and Clinical Immunology  , DOI: ( /j.jaci )

3 FIG 2 General asthma symptoms in subjects with early-onset (A) or late-onset (B) asthma are greater in those with eosinophilia. Journal of Allergy and Clinical Immunology  , DOI: ( /j.jaci )

4 FIG 3 Eosinophilic inflammation in early-onset asthma is associated with increases in CD3 (+) cells, mast cells, and chymase (+) mast cells. Journal of Allergy and Clinical Immunology  , DOI: ( /j.jaci )

5 FIG 4 A, Eosinophilic inflammation in early-onset asthma is associated with increased TGF-β (+) cells. Eosinophils do not associate with differences in TGF-β (+) cells in late-onset asthma. B, Eosinophilic inflammation in early-onset asthma is not associated with differences in SBM thickness. The absence of eosinophilic inflammation in late-onset asthma is associated with a thinner SBM than late onset asthma with eosinophilia. Journal of Allergy and Clinical Immunology  , DOI: ( /j.jaci )

6 FIG 5 Eosinophilic inflammation in early-onset asthma is associated with greater CD3(+) cells, mast cells, and chymase positive mast cells as compared with late-onset asthma. Journal of Allergy and Clinical Immunology  , DOI: ( /j.jaci )