「"author:Nakamoto N"」に一致するユーザー プロフィール
 | Nobuhiro Nakamoto確認したメール アドレス: keio.jp 被引用数: 4764 |
Role of toll-like receptors in immune activation and tolerance in the liver
N Nakamoto, T Kanai - Frontiers in immunology, 2014 - frontiersin.org
Liver has a unique vascular system receiving the majority of the blood supply from the
gastrointestinal tract through the portal vein and faces continuous exposure to foreign …
gastrointestinal tract through the portal vein and faces continuous exposure to foreign …
Gut pathobionts underlie intestinal barrier dysfunction and liver T helper 17 cell immune response in primary sclerosing cholangitis
N Nakamoto, N Sasaki, R Aoki, K Miyamoto… - Nature …, 2019 - nature.com
Primary sclerosing cholangitis (PSC) is a chronic inflammatory liver disease and its frequent
complication with ulcerative colitis highlights the pathogenic role of epithelial barrier …
complication with ulcerative colitis highlights the pathogenic role of epithelial barrier …
Functional restoration of HCV-specific CD8 T cells by PD-1 blockade is defined by PD-1 expression and compartmentalization
N Nakamoto, DE Kaplan, J Coleclough, Y Li, ME Valiga… - Gastroenterology, 2008 - Elsevier
BACKGROUND & AIMS: The immunoinhibitory receptor programmed death 1 (PD-1) is up-
regulated on dysfunctional virus-specific CD8 T cells during chronic viral infections, and …
regulated on dysfunctional virus-specific CD8 T cells during chronic viral infections, and …
Synergistic reversal of intrahepatic HCV-specific CD8 T cell exhaustion by combined PD-1/CTLA-4 blockade
Viral persistence is associated with hierarchical antiviral CD8 T cell exhaustion with
increased programmed death-1 (PD-1) expression. In HCV persistence, HCV-specific CD8 T …
increased programmed death-1 (PD-1) expression. In HCV persistence, HCV-specific CD8 T …
CD8+ tissue-resident memory T cells promote liver fibrosis resolution by inducing apoptosis of hepatic stellate cells
Y Koda, T Teratani, PS Chu, Y Hagihara… - Nature …, 2021 - nature.com
Non-alcoholic steatohepatitis (NASH) is a leading cause of chronic liver disease that can
progress to liver fibrosis. Recent clinical advance suggests a reversibility of liver fibrosis, but …
progress to liver fibrosis. Recent clinical advance suggests a reversibility of liver fibrosis, but …
The liver–brain–gut neural arc maintains the Treg cell niche in the gut
Recent clinical and experimental evidence has evoked the concept of the gut–brain axis to
explain mutual interactions between the central nervous system and gut microbiota that are …
explain mutual interactions between the central nervous system and gut microbiota that are …
Bacteriophage therapy against pathological Klebsiella pneumoniae ameliorates the course of primary sclerosing cholangitis
M Ichikawa, N Nakamoto, S Kredo-Russo… - Nature …, 2023 - nature.com
Primary sclerosing cholangitis (PSC) is characterized by progressive biliary inflammation
and fibrosis. Although gut commensals are associated with PSC, their causative roles and …
and fibrosis. Although gut commensals are associated with PSC, their causative roles and …
Identification and In Vitro Expansion of Functional Antigen-Specific CD25+ FoxP3+ Regulatory T Cells in Hepatitis C Virus Infection
H Ebinuma, N Nakamoto, Y Li, DA Price… - Journal of …, 2008 - Am Soc Microbiol
ABSTRACT CD4+ CD25+ regulatory T cells (CD25+ Tregs) play a key role in immune
regulation. Since hepatitis C virus (HCV) persists with increased circulating CD4+ CD25+ T …
regulation. Since hepatitis C virus (HCV) persists with increased circulating CD4+ CD25+ T …
Th17 cells in the liver: balancing autoimmunity and pathogen defense
N Taniki, N Nakamoto, PS Chu, M Ichikawa… - Seminars in …, 2022 - Springer
In addition to carcinogenesis, T helper 17 (Th17) cells (a subtype of CD4+ T lymphocytes)
are involved in the acute, chronic, and cirrhotic phases of liver diseases; however, their role …
are involved in the acute, chronic, and cirrhotic phases of liver diseases; however, their role …
Commensal consortia decolonize Enterobacteriaceae via ecological control
M Furuichi, T Kawaguchi, MM Pust, K Yasuma-Mitobe… - Nature, 2024 - nature.com
Persistent colonization and outgrowth of potentially pathogenic organisms in the intestine
can result from long-term antibiotic use or inflammatory conditions, and may perpetuate …
can result from long-term antibiotic use or inflammatory conditions, and may perpetuate …