BACKGROUND & AIMS: Inflammatory bowel diseases (IBD) are becoming more common in
Asia, but epidemiologic data are lacking. The Asia-Pacific Crohn’s and Colitis Epidemiology …

Background Host responses during sepsis are highly heterogeneous, which hampers the
identification of patients at high risk of mortality and their selection for targeted therapies. In this …

Objective The rising incidence of inflammatory bowel disease in Asia supports the importance
of environmental risk factors in disease aetiology. This prospective population-based case-…

Depending on the tissue microenvironment, T cells can differentiate into highly diverse
subsets expressing unique trafficking receptors and cytokines. Studies of human lymphocytes …

Preclinical studies have suggested that platelets influence the host response during sepsis.
We sought to assess the association of admission thrombocytopenia with the presentation, …

Introduction A clinical suspicion of infection is mandatory for diagnosing sepsis in patients
with a systemic inflammatory response syndrome. Yet, the accuracy of categorizing critically ill …

Background. Metaanalyses failed to demonstrate clinical benefits of beta lactam plus
aminoglycoside combination therapy compared to beta lactam monotherapy in patients with sepsis. …

Background. Systemic reactivations of herpesviruses may occur in intensive care unit (ICU)
patients, even in those without prior immune deficiency. However, the clinical relevance of …

Purpose The association between benzodiazepine use and delirium risk in the ICU remains
unclear. Prior investigations have failed to account for disease severity prior to delirium …

METHODS: Newly diagnosed IBD cases between 2011 and 2013 from 13 countries or regions
in Asia-Pacific were included. Incidence was calculated with 95% confidence interval (CI) …