The matrix metalloproteinases (MMPs) are a family of zinc-dependent proteinases involved
in the degradation of the extracellular matrix. The MMPs have been implicated in the …

Matrix metalloproteinases (MMPs) are a family of extracellular matrix degrading proteinases.
Owing to their matrix-degrading abilities and high expression in advanced tumors, MMPs …

Over the past 20 years, the tissue inhibitors of metalloproteinases (TIMPs) have been
implicated in direct regulation of cell growth and apoptosis. However, the mechanisms of …

Neoplastic cells form only one part of a complex network of cell types that make up a breast
tumor. The normal cell types that make up the nonneoplastic components of tumors include …

Matrix metalloproteinases (MMPs) have a great variability that provides a complex
intervention in pathophysiological conditions. MMPs roles in pathology may be grouped into …

Angiogenesis is essential for tumour growth, invasion, and metastasis. Tumour blood
vessels show many differences from normal vessels and are not genetically unstable, so …

Tissue Inhibitor of Metalloproteases 1, also known as TIMP-1, is named for its well-
established function of inhibiting the proteolytic activity of matrix metalloproteases. Given this …

Malignant tumors are characterized by dysregulated growth control, overcoming of
replicative senescence, and metastasis formation. Current therapeutic regimens mostly exert …

Except in breast and ovarian cancer, the presence of malignant ascites in patients with
neoplastic diseases frequently heralds the terminal phase of cancer. It is a poor prognostic …

Malignant ascites (MA) accompanies a variety of abdominal and extra-abdominal tumors. It
is a primary cause of morbidity and raises several treatment challenges. MA has several …