Inorganic nanoparticles in clinical trials and translations
H Huang, W Feng, Y Chen, J Shi - Nano today, 2020 - Elsevier
The development and application of nanotechnology-related knowledge and tools in
modern medicine has been showing great potentials in elevating human's living standards …
modern medicine has been showing great potentials in elevating human's living standards …
Nanotechnology strategies to advance outcomes in clinical cancer care
CM Hartshorn, MS Bradbury, GM Lanza, AE Nel… - ACS …, 2018 - ACS Publications
Ongoing research into the application of nanotechnology for cancer treatment and diagnosis
has demonstrated its advantages within contemporary oncology as well as its intrinsic …
has demonstrated its advantages within contemporary oncology as well as its intrinsic …
Ultrasmall nanoparticles induce ferroptosis in nutrient-deprived cancer cells and suppress tumour growth
The design of cancer-targeting particles with precisely tuned physicochemical properties
may enhance the delivery of therapeutics and access to pharmacological targets. However …
may enhance the delivery of therapeutics and access to pharmacological targets. However …
Ultrasmall inorganic nanoparticles: State-of-the-art and perspectives for biomedical applications
K Zarschler, L Rocks, N Licciardello, L Boselli… - … , Biology and Medicine, 2016 - Elsevier
Ultrasmall nanoparticulate materials with core sizes in the 1-3 nm range bridge the gap
between single molecules and classical, larger-sized nanomaterials, not only in terms of …
between single molecules and classical, larger-sized nanomaterials, not only in terms of …
Engineering CAR-T cells to activate small-molecule drugs in situ
TJ Gardner, JP Lee, CM Bourne… - Nature chemical …, 2022 - nature.com
Chimeric antigen receptor (CAR)-T cells represent a major breakthrough in cancer therapy,
wherein a patient's own T cells are engineered to recognize a tumor antigen, resulting in …
wherein a patient's own T cells are engineered to recognize a tumor antigen, resulting in …
Dye-doped silica nanoparticles: synthesis, surface chemistry and bioapplications
V Gubala, G Giovannini, F Kunc, MP Monopoli… - Cancer …, 2020 - Springer
Background Fluorescent silica nanoparticles have been extensively utilised in a broad
range of biological applications and are facilitated by their predictable, well-understood …
range of biological applications and are facilitated by their predictable, well-understood …
Ultrasmall core-shell silica nanoparticles for precision drug delivery in a high-grade malignant brain tumor model
Purpose: Small-molecule inhibitors have revolutionized treatment of certain genomically
defined solid cancers. Despite breakthroughs in treating systemic disease, central nervous …
defined solid cancers. Despite breakthroughs in treating systemic disease, central nervous …
Renal clearable quantum dot–drug conjugates modulate labile iron species and scavenge free radicals for attenuating chemotherapeutic drug-induced acute kidney …
Chemotherapeutic drug-induced acute kidney injury (AKI) involves pathologically increased
labile iron species in the kidneys that mediate the excessive generation of reactive oxygen …
labile iron species in the kidneys that mediate the excessive generation of reactive oxygen …
Cancer-targeting ultrasmall silica nanoparticles for clinical translation: physicochemical structure and biological property correlations
Although a large body of literature exists on the potential use of nanoparticles for medical
applications, the number of probes translated into human clinical trials is remarkably small …
applications, the number of probes translated into human clinical trials is remarkably small …
Linker stability influences the anti-tumor activity of acetazolamide-drug conjugates for the therapy of renal cell carcinoma
S Cazzamalli, A Dal Corso, D Neri - Journal of Controlled Release, 2017 - Elsevier
Small molecule-drug conjugates (SMDCs) are increasingly being considered as an
alternative to antibody-drug conjugates (ADCs) for the selective delivery of anticancer …
alternative to antibody-drug conjugates (ADCs) for the selective delivery of anticancer …