Ensemble-level organization of human kinetochores and evidence for distinct tension and attachment sensors
E Roscioli, TE Germanova, CA Smith, PA Embacher… - Cell reports, 2020 - cell.com
Kinetochores are multi-protein machines that form dynamic attachments to microtubules and
control chromosome segregation. High fidelity is ensured because kinetochores can monitor …
control chromosome segregation. High fidelity is ensured because kinetochores can monitor …
[HTML][HTML] CENP-F stabilizes kinetochore-microtubule attachments and limits dynein stripping of corona cargoes
P Auckland, E Roscioli, HLE Coker… - Journal of Cell Biology, 2020 - rupress.org
Accurate chromosome segregation demands efficient capture of microtubules by
kinetochores and their conversion to stable bioriented attachments that can congress and …
kinetochores and their conversion to stable bioriented attachments that can congress and …
α-tubulin detyrosination fine-tunes kinetochore-microtubule attachments
H Girão, J Macário-Monteiro, AC Figueiredo… - Nature …, 2024 - nature.com
Post-translational cycles of α-tubulin detyrosination and tyrosination generate microtubule
diversity, the cellular functions of which remain largely unknown. Here we show that α …
diversity, the cellular functions of which remain largely unknown. Here we show that α …
Spindle-length-dependent HURP localization allows centrosomes to control kinetochore-fiber plus-end dynamics
During mitosis, centrosomes affect the length of kinetochore fibers (k-fibers) and the stability
of kinetochore-microtubule attachments, implying that they regulate k-fiber dynamics …
of kinetochore-microtubule attachments, implying that they regulate k-fiber dynamics …
WDR62 localizes katanin at spindle poles to ensure synchronous chromosome segregation
Mutations in the WDR62 gene cause primary microcephaly, a pathological condition often
associated with defective cell division that results in severe brain developmental defects …
associated with defective cell division that results in severe brain developmental defects …
Centrosomes control kinetochore-fiber plus-end dynamics via HURP to ensure symmetric divisions
During mitosis centrosomes can affect the length of kinetochore-fibers (k-fibers) and the
stability of kinetochore-microtubule attachments, implying that they regulate k-fiber …
stability of kinetochore-microtubule attachments, implying that they regulate k-fiber …