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Extract from the Register of European Patents

EP About this file: EP3552488

EP3552488 - ANIMAL MODEL FOR NEPHROPATHY AND AGENTS FOR TREATING THE SAME [Right-click to bookmark this link]
StatusThe application is deemed to be withdrawn
Status updated on  02.10.2020
Database last updated on 14.12.2024
FormerThe application has been published
Status updated on  13.09.2019
Most recent event   Tooltip02.10.2020Application deemed to be withdrawnpublished on 04.11.2020  [2020/45]
Applicant(s)For all designated states
F. Hoffmann-La Roche AG
Grenzacherstrasse 124
4070 Basel / CH
[2019/42]
Inventor(s)01 / WILSON, Deanna Grant
c/o Genentech, Inc.
1 DNA Way
South San Francisco, California 94080 / US
02 / FOREMAN, Oded
c/o Genentech, Inc.
1 DNA Way
South San Francisco, California 94080 / US
03 / PETERSON, Andrew
c/o Genentech, Inc.
1 DNA Way
South San Francisco, California 94080 / US
04 / WEN, Xiaohui
c/o Genentech, Inc.
1 DNA Way
South San Francisco, California 94080 / US
05 / SCALES, Suzanna J.
c/o Genentech, Inc.
1 DNA Way
South San Francisco, California 94080 / US
 [2019/42]
Representative(s)Brodbeck, Michel
F. Hoffmann-La Roche AG
Patent Department
Grenzacherstrasse 124
4070 Basel / CH
[2019/42]
Application number, filing date19152929.610.11.2015
[2019/42]
Priority number, dateUS201462077774P10.11.2014         Original published format: US 201462077774 P
[2019/42]
Previously filed application, dateWO2015US5998710.11.2015
[2019/42]
Filing languageEN
Procedural languageEN
PublicationType: A1 Application with search report 
No.:EP3552488
Date:16.10.2019
Language:EN
[2019/42]
Search report(s)(Supplementary) European search report - dispatched on:EP16.08.2019
ClassificationIPC:A01K67/027, C12N15/85, C07K16/18, C07K14/775, A61K49/00
[2019/42]
CPC:
A01K67/0275 (EP,CN,US); C07K14/775 (EP,CN,US); A61K39/395 (CN);
A61K49/0008 (EP,CN,US); A61P13/12 (EP); C07K16/2875 (EP,CN,US);
C12N15/8509 (EP,CN,US); G01N33/92 (CN); A01K2217/052 (EP,CN,US);
A01K2227/105 (EP,CN,US); A01K2267/035 (EP,CN,US); C07K16/00 (US);
C12N2015/8527 (US); G01N2800/347 (US) (-)
Designated contracting statesAL,   AT,   BE,   BG,   CH,   CY,   CZ,   DE,   DK,   EE,   ES,   FI,   FR,   GB,   GR,   HR,   HU,   IE,   IS,   IT,   LI,   LT,   LU,   LV,   MC,   MK,   MT,   NL,   NO,   PL,   PT,   RO,   RS,   SE,   SI,   SK,   SM,   TR [2019/42]
TitleGerman:TIERMODELL FÜR NEPHROPATHIE UND MITTEL ZUR BEHANDLUNG DAVON[2019/42]
English:ANIMAL MODEL FOR NEPHROPATHY AND AGENTS FOR TREATING THE SAME[2019/42]
French:MODÈLE ANIMAL POUR UNE NÉPHROPATHIE ET AGENTS POUR LA TRAITER[2019/42]
Examination procedure03.06.2020Application deemed to be withdrawn, date of legal effect  [2020/45]
30.06.2020Despatch of communication that the application is deemed to be withdrawn, reason: renewal fee not paid in time  [2020/45]
Parent application(s)   TooltipEP15798303.2  / EP3217787
Fees paidRenewal fee
22.05.2019Renewal fee patent year 03
22.05.2019Renewal fee patent year 04
Penalty fee
Additional fee for renewal fee
30.11.201905   M06   Not yet paid
Opt-out from the exclusive  Tooltip
competence of the Unified
Patent Court
See the Register of the Unified Patent Court for opt-out data
Responsibility for the accuracy, completeness or quality of the data displayed under the link provided lies entirely with the Unified Patent Court.
Documents cited:Search[XY]WO2011020865  (UNIV BRUXELLES [BE], et al) [X] 1-5,8,26,27,30-36,40-44 * paragraph [0004] - paragraph [0011] * * paragraph [0028] - paragraph [0036]; claim -; sequence - * [Y] 1-5,8,9,26-44;
 [XY]WO2012162394  (BETH ISRAEL HOSPITAL [US], et al) [X] 1,2,5,8,26-44 * page 44, line 1 - page 49, line 24; example 6; claim - * [Y] 1-5,8,9,26-44;
 [XY]US2011030078  (RAPER JAYNE [US], et al) [X] 1-4,8,26,27,30-36,40 * page 2, paragraph 0010; claim -; sequence - * [Y] 1-5,8,9,26-44;
 [XY]  - THOMSON R ET AL, "Evolution of the primate trypanolytic factor APOL1", PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES, US, (20140507), vol. 111, no. 20, doi:10.1073/pnas.1400699111, ISSN 0027-8424, pages E2130 - E2139, XP055243608 [X] 1-4,8,26,27,30-36,40 * abstract, results, materials and methods,;; figures 4B-E, 5B * [Y] 1-5,8,9,26-44

DOI:   https://dx.doi.org/10.1073/pnas.1400699111
 [XY]  - MOLINA-PORTELA M P ET AL, "Distinct roles of apolipoprotein components within the trypanosome lytic factor complex revealed in a novel transgenic mouse model", THE JOURNAL OF EXPERIMENTAL MEDICINE, ROCKEFELLER UNIVERSITY PRESS, US, vol. 205, no. 8, doi:10.1084/JEM.20071463, ISSN 0022-1007, (20080801), pages 1721 - 1728, (20080804), XP002584510 [X] 1-4,8,26,27,30-36,40 * abstract, materials and methods; * [Y] 1-5,8,9,26-44

DOI:   https://dx.doi.org/10.1084/JEM.20071463
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 US2012128682
 US2012195902
 US2012003644
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 WO03035694
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    - CHOTHIA; LESK, J. Mol. Biol., (19870000), vol. 196, pages 901 - 917
    - ZAPATA et al., Protein Eng., (19950000), vol. 8, no. 10, pages 1057 - 1062
    - PLIICKTHUN, The Pharmacology of Monoclonal Antibodies, Springer-Verlag, (19940000), vol. 113, pages 269 - 315
    - HOLLINGER et al., Proc. Natl. Acad. Sci. USA, (19930000), vol. 90, pages 6444 - 6448
    - Nature, (19890000), vol. 341, pages 544 - 546
    - Dev Comp Immunol, (20060000), vol. 30, pages 43 - 56
    - Trend Biochem Sci, (20010000), vol. 26, pages 230 - 235
    - Trends Biotechnol, (20030000), vol. 21, pages 484 - 490
    - Febs Lett, (19940000), vol. 339, pages 285 - 290
    - KOHLER et al., Nature, (19750000), vol. 256, page 495
    - CLACKSON et al., Nature, (19910000), vol. 352, pages 624 - 628
    - MARKS et al., J. Mol. Biol., (19910000), vol. 222, pages 581 - 597
    - MORRISON et al., Proc. Natl. Acad. Sci. USA, (19840000), vol. 81, pages 6851 - 6855
    - KINDT et al., Kuby Immunology, W.H. Freeman and Co., (20070000), page 91
    - PORTOLANO et al., J. Immunol., (19930000), vol. 150, pages 880 - 887
    - CLARKSON et al., Nature, (19910000), vol. 352, pages 624 - 628
    - CHEN et al., J. Mol. Biol., (19990000), vol. 293, pages 865 - 881
    - PRESTA et al., Cancer Res., (19970000), vol. 57, pages 4593 - 4599
    - HUDSON et al., Nat. Med., (20030000), vol. 9, pages 129 - 134
    - PLUCKTHUN, The Pharmacology of Monoclonal Antibodies, Springer-Verlag, (19940000), vol. 113, pages 269 - 315
    - ALMAGRO; FRANSSON, Front. Biosci., (20080000), vol. 13, pages 1619 - 1633
    - RIECHMANN et al., Nature, (19880000), vol. 332, pages 323 - 329
    - QUEEN et al., Proc. Nat'l Acad. Sci. USA, (19890000), vol. 86, pages 10029 - 10033
    - KASHMIRI et al., Methods, (20050000), vol. 36, pages 25 - 34
    - PADLAN, Mol. Immunol., (19910000), vol. 28, pages 489 - 498
    - DALL'ACQUA et al., Methods, (20050000), vol. 36, pages 43 - 60
    - OSBOURN et al., Methods, (20050000), vol. 36, pages 61 - 68
    - KLIMKA et al., Br. J. Cancer, (20000000), vol. 83, pages 252 - 260
    - SIMS et al., J. Immunol., (19930000), vol. 151, page 2296
    - CARTER et al., Proc. Natl. Acad. Sci. USA, (19920000), vol. 89, page 4285
    - PRESTA et al., J. Immunol., (19930000), vol. 151, page 2623
    - BACA et al., J. Biol. Chem., (19970000), vol. 272, pages 10678 - 10684
    - ROSOK et al., J. Biol. Chem., (19960000), vol. 271, pages 22611 - 22618
    - VAN DIJK AND VAN DE WINKEL, Curr. Opin. Pharmacol., (20010000), vol. 5, pages 368 - 74
    - LONBERG, Curr. Opin. Immunol., (20080000), vol. 20, pages 450 - 459
    - LONBERG, Nat. Biotech., (20050000), vol. 23, pages 1117 - 1125
    - KOZBOR, J. Immunol., (19840000), vol. 133, page 3001
    - BRODEUR et al., Monoclonal Antibody Production Techniques and Applications, Marcel Dekker, Inc., (19870000), pages 51 - 63
    - BOERNER et al., J. Immunol., (19910000), vol. 147, page 86
    - LI et al., Proc. Natl. Acad. Sci. USA, (20060000), vol. 103, pages 3557 - 3562
    - NI, Xiandai Mianyixue, (20060000), vol. 26, no. 4, pages 265 - 268
    - VOLLMERS; BRANDLEIN, Histology and Histopathology, (20050000), vol. 20, no. 3, pages 927 - 937
    - VOLLMERS; BRANDLEIN, Methods and Findings in Experimental and Clinical Pharmacology, (20050000), vol. 27, no. 3, pages 185 - 91
    - HOOGENBOOM et al., Methods in Molecular Biology, Human Press, (20010000), vol. 178, pages 1 - 37
    - MCCAFFERTY et al., Nature, vol. 348, pages 552 - 554
    - MARKS et al., J. Mol. Biol., (19920000), vol. 222, pages 581 - 597
    - MARKS; BRADBURY, Methods in Molecular Biology, Human Press, (20030000), vol. 248, pages 161 - 175
    - SIDHU et al., J. Mol. Biol., (20040000), vol. 338, no. 2, pages 299 - 310
    - LEE et al., J. Mol. Biol., (20040000), vol. 340, no. 5, pages 1073 - 1093
    - FELLOUSE, Proc. Natl. Acad. Sci. USA, (20040000), vol. 101, no. 34, pages 12467 - 12472
    - LEE et al., J. Immunol. Methods, (20040000), vol. 284, no. 1-2, pages 119 - 132
    - WINTER et al., Ann. Rev. Immunol., (19940000), vol. 12, pages 433 - 455
    - GRIFFITHS et al., EMBOJ, (19930000), vol. 12, pages 725 - 734
    - HOOGENBOOM; WINTER, J. Mol. Biol., (19920000), vol. 227, pages 381 - 388
    - MILSTEIN; CUELLO, Nature, (19830000), vol. 305, page 537
    - TRAUNECKER et al., EMBO J., (19910000), vol. 10, page 3655
    - BRENNAN et al., Science, (19850000), vol. 229, page 81
    - KOSTELNY et al., J. Immunol., (19920000), vol. 148, no. 5, pages 1547 - 1553
    - GRUBER et al., J. Immunol., (19940000), vol. , 152, page 5368
    - TUTT et al., J. Immunol., (19910000), vol. 147, page 60
    - CHOWDHURY, Methods Mol. Biol., (20080000), vol. 207, pages 179 - 196
    - CUNNINGHAM; WELLS, Science, (19890000), vol. 244, pages 1081 - 1085
    - WRIGHT et al., TIBTECH, (19970000), vol. 15, pages 26 - 32
    - OKAZAKI et al., J. Mol. Biol., (20040000), vol. 336, pages 1239 - 1249
    - YAMANE-OHNUKI et al., Biotech. Bioeng., (20040000), vol. 87, page 614
    - RIPKA et al., Arch. Biochem. Biophys., (19860000), vol. 249, pages 533 - 545
    - KANDA, Y. et al., Biotechnol. Bioeng., (20060000), vol. 94, no. 4, pages 680 - 688
    - RAVETCH; KINET, Annu. Rev. Immunol., (19910000), vol. 9, pages 457 - 492
    - HELLSTROM, I. et al., Proc. Nat'l Acad. Sci. USA, (19860000), vol. 83, pages 7059 - 7063
    - HELLSTROM, I et al., Proc. Nat'l Acad. Sci. USA, (19850000), vol. 82, pages 1499 - 1502
    - PROC. NAT'L ACAD. SCI. USA, vol. 5, no. 821
    - BRUGGEMANN, M. et al., J. Exp. Med., (19870000), vol. 166, pages 1351 - 1361
    - CLYNES et al., Proc. Nat'l Acad. Sci. USA, (19980000), vol. 95, pages 652 - 656
    - GAZZANO-SANTORO et al., J Immunol. Methods, (19960000), vol. 202, page 163
    - CRAGG, M.S. et al., Blood, (20030000), vol. 101, pages 1045 - 1052
    - CRAGG, M.S.; M.J. GLENNIE, Blood, (20040000), vol. 103, pages 2738 - 2743
    - PETKOVA, S.B. et al., Int'l. Immunol., (20060000), vol. 18, no. 12, pages 1759 - 1769
    - SHIELDS et al., J. Biol. Chem., (20010000), vol. 9, no. 2, pages 6591 - 6604
    - IDUSOGIE et al., J. Immunol., (20000000), vol. 164, pages 4178 - 4184
    - GUYER et al., J. Immunol., (19760000), vol. 117, page 587
    - KIM et al., J. Immunol., (19940000), vol. 24, page 249
    - DUNCAN; WINTER, Nature, (19880000), vol. 322, pages 738 - 40
    - KAM et al., Proc. Natl. Acad. Sci. USA, (20050000), vol. 102, pages 11600 - 11605
    - CHARLTON, Methods in Molecular Biology, Humana Press, (20030000), vol. 248, pages 245 - 254
    - GERNGROSS, Nat. Biotech., (20040000), vol. 22, pages 1409 - 1414
    - LI et al., Nat. Biotech., (20060000), vol. 24, pages 210 - 215
    - GRAHAM et al., J. Gen Virol., (19770000), vol. 36, page 59
    - MATHER, Biol. Reprod., (19800000), vol. 23, pages 243 - 251
    - MATHER et al., Annals N.Y. Acad. Sci., (19820000), vol. 383, pages 44 - 68
    - URLAUB et al., Proc. Natl. Acad. Sci. USA, (19800000), vol. 77, page 4216
    - YAZAKI; WU, Methods in Molecular Biology, Humana Press, (20030000), vol. 248, pages 255 - 268
    - "Epitope Mapping Protocols", MORRIS, Methods in Molecular Biology, Humana Press, (19960000), vol. 66
    - WARMING et al., Nucleic Acids Res, (20050000), vol. 33, page e36
    - CHAPMAN, M.J.; GOLDSTEIN, S.; LAGRANGE, D.; LAPLAUD, P.M., "A density gradient ultracentrifugal procedure for the isolation of the major lipoprotein classes from human serum", J Lipid Res, (19810000), vol. 22, pages 339 - 358
    - DAVIDSON, W.S.; SILVA, R.A.; CHANTEPIE, S.; LAGOR, W.R.; CHAPMAN, M.J.; KONTUSH, A., "Proteomic analysis of defined HDL subpopulations reveals particle-specific protein clusters: relevance to antioxidative function", Arterioscler Thromb Vasc Biol, (20090000), vol. 29, pages 870 - 876
    - DUCHATEAU, P.N.; MOVSESYAN, I.; YAMASHITA, S.; SAKAI, N.; HIRANO, K.; SCHOENHAUS, S.A.; O'CONNOR-KEARNS, P.M.; SPENCER, S.J.; JAFF, "Plasma apolipoprotein L concentrations correlate with plasma triglycerides and cholesterol levels in normolipidemic, hyperlipidemic, and diabetic subjects", J Lipid Res, (20000000), vol. 41, pages 1231 - 1236, XP055505782
    - DUCHATEAU, P.N.; PULLINGER, C.R.; ORELLANA, R.E.; KUNITAKE, S.T.; NAYA-VIGNE, J.; O'CONNOR, P.M.; MALLOY, M.J.; KANE, J.P., "Apolipoprotein L, a new human high density lipoprotein apolipoprotein expressed by the pancreas. Identification, cloning, characterization, and plasma distribution of apolipoprotein L", The Journal of biological chemistry, (19970000), vol. 272, doi:doi:10.1074/jbc.272.41.25576, pages 25576 - 25582, XP002136974

DOI:   https://dx.doi.org/10.1074/jbc.272.41.25576
    - FREEDMAN, B.I.; KOPP, J.B.; LANGEFELD, C.D.; GENOVESE, G.; FRIEDMAN, D.J.; NELSON, G.W.; WINKLER, C.A.; BOWDEN, D.W.; POLLAK, M.R., "The apolipoprotein L1 (APOL1) gene and nondiabetic nephropathy in African Americans", J Am Soc Nephrol, (20100000), vol. 21, pages 1422 - 1426, XP009149968
    - FREEDMAN, B.I.; LANGEFELD, C.D.; LU, L.; DIVERS, J.; COMEAU, M.E.; KOPP, J.B.; WINKLER, C.A.; NELSON, G.W.; JOHNSON, R.C.; PALMER,, "Differential effects of MYH9 and APOL1 risk variants on FRMD3 Association with Diabetic ESRD in African Americans", PLoS Genet, (20110000), vol. 7, page e1002150
    - HSU, C.Y.; LIN, F.; VITTINGHOFF, E.; SHLIPAK, M.G., "Racial differences in the progression from chronic renal insufficiency to end-stage renal disease in the United States", J Am Soc ___ _ _ Nephrol, (20030000), vol. 14, pages 2902 - 2907
    - KAO, W.H.; KLAG, M.J.; MEONI, L.A.; REICH, D.; BERTHIER-SCHAAD, Y.; LI, M.; CORESH, J.; PATTERSON, N.; TANDON, A.; POWE, N.R., "MYH9 is associated with nondiabetic end-stage renal disease in African Americans", Nature genetics, (20080000), vol. 40, doi:doi:10.1038/NG.232, pages 1185 - 1192, XP002532779

DOI:   https://dx.doi.org/10.1038/NG.232
    - KOPP, J.B.; NELSON, G.W.; SAMPATH, K.; JOHNSON, R.C.; GENOVESE, G.; AN, P.; FRIEDMAN, D.; BRIGGS, W.; DART, R.; KORBET, S., "APOL1 genetic variants in focal segmental glomerulosclerosis and HIV-associated nephropathy", J Am Soc Nephrol, (20110000), vol. 22, pages 2129 - 2137
    - KOPP, J.B.; SMITH, M.W.; NELSON, G.W.; OHNSON, R.C.; FREEDMAN, B.I.; BOWDEN, D.W.; OLEKSYK, T.; MCKENZIE, L.M.; KAJIYAMA, H.; AHUJ, "MYH9 is a major-effect risk gene for focal segmental glomerulosclerosis", Nature genetics, (20080000), vol. 40, doi:doi:10.1038/NG.226, pages 1175 - 1184, XP002532777

DOI:   https://dx.doi.org/10.1038/NG.226
    - LEE, V.W.; HARRIS, D.C., "Adriamycin nephropathy: a model of focal segmental glomerulosclerosis", Nephrology (Carlton, (20110000), vol. 16, pages 30 - 38
    - MADHAVAN, S.M.; O'TOOLE, J.F.; ONIECZKOWSKI, M.; GANESAN, S.; BRUGGEMAN, L.A.; SEDOR, J.R., "APOL1 localization in normal kidney and nondiabetic kidney disease", J Am Soc Nephrol, (20110000), vol. 22, pages 2119 - 2128
    - MCPHERSON, P.A.; YOUNG, I.S.; MCKIBBEN, B.; MCENENY, J., "High density lipoprotein subfractions: isolation, composition, and their duplicitous role in oxidation", J Lipid Res, (20070000), vol. 48, pages 86 - 95
    - PAGE, N.M.; OLANO-MARTIN, E.; LANAWAY, C.; TURNER, R.; MINIHANE, A.M., "Polymorphisms in the Apolipoprotein Ll gene and their effects on blood lipid and glucose levels in middle age_ males", Genes Nutr, (20060000), vol. 1, pages 133 - 135
    - ARSA, A.; KAO, W.H.; XIE, D.; ASTOR, B.C.; LI, M.; HSU, C.Y.; FELDMAN, H.I.; PAREKH, R.S.; KUSEK, J.W.; GREENE, T.H., "APOL1 risk variants, race, and progression of chronic kidney disease", N Engl J Med, (20130000), vol. 369, pages 2183 - 2196
    - SALEEM, M.A.; O'HARE, M.J.; REISER, J.; COWARD, R.J.; INWARD, C.D.; FARREN, T.; XING, C.Y.; NI, L.; MATHIESON, P.W.; MUNDEL, P., "A conditionally immortalized human podocyte cell line demonstrating nephrin and podocin expression", J Am Soc Nephrol, (20020000), vol. 13, pages 630 - 638
The EPO accepts no responsibility for the accuracy of data originating from other authorities; in particular, it does not guarantee that it is complete, up to date or fit for specific purposes.