You are using an outdated browser. Please upgrade your browser to improve your experience.

Tbio
FGF13
Fibroblast growth factor 13

Protein Summary
Description
Microtubule-binding protein which directly binds tubulin and is involved in both polymerization and stabilization of microtubules. Through its action on microtubules, may participate to the refinement of axons by negatively regulating axonal and leading processes branching. Plays a crucial role in neuron polarization and migration in the cerebral cortex and the hippocampus. May regulate voltage-gated sodium channels transport and function. May also play a role in MAPK signaling. The protein encoded by this gene is a member of the fibroblast growth factor (FGF) family. FGF family members possess broad mitogenic and cell survival activities, and are involved in a variety of biological processes, including embryonic development, cell growth, morphogenesis, tissue repair, tumor growth, and invasion. This gene is located in a region on chromosome X, which is associated with Borjeson-Forssman-Lehmann syndrome (BFLS), making it a possible candidate gene for familial cases of the BFLS, and for ...more
Uniprot Accession IDs
Gene Name
Ensembl ID
  • ENST00000305414
  • ENSP00000303391
  • ENSG00000129682
  • ENST00000315930
  • ENSP00000322390
  • ENST00000436198
  • ENSP00000396198
  • ENST00000441825
  • ENSP00000409276
  • ENST00000626909
  • ENSP00000487411

Symbol
  • FHF2
  • FGF2
  • FHF2
  • FHF-2
  • FGF-13
Illumination Graph
Knowledge Table
Most Knowledge About
Knowledge Value (0 to 1 scale)
biological process
0.94
PubMedID
0.87
transcription factor perturbation
0.84
small molecule perturbation
0.74
molecular function
0.73


IDG Development Level Summary
Tdark

These are targets about which virtually nothing is known. They do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:

Pubmed score: 1452.78   (req: < 5)
View Publications
Gene RIFs: 32   (req: <= 3)
View Gene RIFs
Antibodies: 533   (req: <= 50)
View Antibodies
Tbio

These targets do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:

Pubmed score: 1452.78   (req: >= 5)
Gene RIFs: 32   (req: > 3)
Antibodies: 533   (req: > 50)

- OR - satisfy the following criterion:

Gene Ontology Terms: 22
View GO Terms
Tchem

Target has at least one ChEMBL compound with an activity cutoff of < 30 nM - AND - satisfies the preceding conditions

Active Ligand: 0
Tclin

Target has at least one approved drug - AND - satisfies the preceding conditions

Active Drug: 0