ZA983740B - Novel amidine derivatives and their use in therapy - Google Patents

Novel amidine derivatives and their use in therapy

Info

Publication number
ZA983740B
ZA983740B ZA983740A ZA983740A ZA983740B ZA 983740 B ZA983740 B ZA 983740B ZA 983740 A ZA983740 A ZA 983740A ZA 983740 A ZA983740 A ZA 983740A ZA 983740 B ZA983740 B ZA 983740B
Authority
ZA
South Africa
Prior art keywords
therapy
amidine derivatives
novel amidine
novel
derivatives
Prior art date
Application number
ZA983740A
Other languages
English (en)
Inventor
James Macdonald
James Matz
William Shakespeare
Original Assignee
Astra Ab
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Astra Ab filed Critical Astra Ab
Publication of ZA983740B publication Critical patent/ZA983740B/xx

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D409/00—Heterocyclic compounds containing two or more hetero rings, at least one ring having sulfur atoms as the only ring hetero atoms
    • C07D409/02—Heterocyclic compounds containing two or more hetero rings, at least one ring having sulfur atoms as the only ring hetero atoms containing two hetero rings
    • C07D409/12—Heterocyclic compounds containing two or more hetero rings, at least one ring having sulfur atoms as the only ring hetero atoms containing two hetero rings linked by a chain containing hetero atoms as chain links
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P25/00—Drugs for disorders of the nervous system
    • A61P25/06—Antimigraine agents
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P25/00—Drugs for disorders of the nervous system
    • A61P25/14—Drugs for disorders of the nervous system for treating abnormal movements, e.g. chorea, dyskinesia
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P25/00—Drugs for disorders of the nervous system
    • A61P25/14—Drugs for disorders of the nervous system for treating abnormal movements, e.g. chorea, dyskinesia
    • A61P25/16—Anti-Parkinson drugs
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P25/00—Drugs for disorders of the nervous system
    • A61P25/18—Antipsychotics, i.e. neuroleptics; Drugs for mania or schizophrenia
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P43/00—Drugs for specific purposes, not provided for in groups A61P1/00-A61P41/00
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P9/00—Drugs for disorders of the cardiovascular system

Landscapes

  • Health & Medical Sciences (AREA)
  • Organic Chemistry (AREA)
  • Chemical & Material Sciences (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Engineering & Computer Science (AREA)
  • Veterinary Medicine (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Public Health (AREA)
  • General Health & Medical Sciences (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • General Chemical & Material Sciences (AREA)
  • Medicinal Chemistry (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Animal Behavior & Ethology (AREA)
  • Biomedical Technology (AREA)
  • Neurosurgery (AREA)
  • Neurology (AREA)
  • Psychology (AREA)
  • Pain & Pain Management (AREA)
  • Psychiatry (AREA)
  • Cardiology (AREA)
  • Heart & Thoracic Surgery (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Plural Heterocyclic Compounds (AREA)
ZA983740A 1997-05-05 1998-05-04 Novel amidine derivatives and their use in therapy ZA983740B (en)

Applications Claiming Priority (1)

Application Number Priority Date Filing Date Title
SE9701682A SE9701682D0 (sv) 1997-05-05 1997-05-05 Compounds

Publications (1)

Publication Number Publication Date
ZA983740B true ZA983740B (en) 1999-02-19

Family

ID=20406836

Family Applications (1)

Application Number Title Priority Date Filing Date
ZA983740A ZA983740B (en) 1997-05-05 1998-05-04 Novel amidine derivatives and their use in therapy

Country Status (28)

Country Link
US (1) US6166030A (de)
EP (1) EP0983266B1 (de)
JP (1) JP2001523263A (de)
KR (1) KR20010012227A (de)
CN (1) CN1255130A (de)
AR (1) AR012602A1 (de)
AT (1) ATE210661T1 (de)
AU (1) AU734394B2 (de)
BR (1) BR9808725A (de)
CA (1) CA2287999A1 (de)
DE (1) DE69802923T2 (de)
DK (1) DK0983266T3 (de)
EE (1) EE9900475A (de)
ES (1) ES2168757T3 (de)
HU (1) HUP0003766A3 (de)
ID (1) ID23156A (de)
IL (1) IL132677A0 (de)
IS (1) IS5237A (de)
MX (1) MXPA99009874A (de)
NO (1) NO995404L (de)
NZ (1) NZ500676A (de)
PL (1) PL336854A1 (de)
PT (1) PT983266E (de)
SE (1) SE9701682D0 (de)
SK (1) SK140699A3 (de)
TR (1) TR199902719T2 (de)
WO (1) WO1998050380A1 (de)
ZA (1) ZA983740B (de)

Families Citing this family (8)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
WO2001024826A2 (en) * 1999-10-06 2001-04-12 The Brigham And Women's Hospital, Inc. Inrease of enos activity through activation of the pi3-kinase/akt pathway by estrogens
US6683108B1 (en) * 2000-03-30 2004-01-27 Curis, Inc. Agonists of hedgehog signaling pathways and uses related thereto
US8852937B2 (en) * 2000-03-30 2014-10-07 Curis, Inc. Small organic molecule regulators of cell proliferation
US7115653B2 (en) * 2000-03-30 2006-10-03 Curis, Inc. Small organic molecule regulators of cell proliferation
US20030045449A1 (en) * 2001-08-15 2003-03-06 Pfizer, Inc. Pharmaceutical combinations for the treatment of neurodegenerative diseases
DK1883451T3 (da) 2005-04-13 2011-03-14 Neuraxon Inc Substituerede indolforbindelser med NOS-hæmmende virkning
CL2008000838A1 (es) * 2007-03-23 2008-10-10 Neuraxon Inc Compuestos derivados de quinolina y tetrahidroquinolina, con actividad inhibidora nos; composicion farmaceutica que comprende a dichos compuestos; y su uso para tratar un dolor de cabeza tal como migrana, dolor cronico, desordenes del sistema nervios
KR20100103799A (ko) 2007-11-16 2010-09-28 네우렉슨 인코포레이티드 내장통을 치료하기 위한 인돌 화합물 및 방법

Family Cites Families (5)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
JPH09504278A (ja) * 1944-06-01 1997-04-28 ザ、ウェルカム、ファンデーション、リミテッド Ｎｏシンターゼインヒビターとしての置換尿素およびイソチオ尿素誘導体
RU2130017C1 (ru) * 1993-08-12 1999-05-10 Астра Актиенболаг Производные амидина, способ их получения и лекарственное средство на их основе, обладающее свойством ингибировать активность синтетазы оксида азота (у)
JPH09504028A (ja) * 1993-10-21 1997-04-22 ジー．ディー．サール アンド カンパニー 酸化窒素シンターゼ抑制剤として有用なアミジノ誘導体
WO1996001817A1 (en) * 1994-05-07 1996-01-25 Astra Aktiebolag Bicyclic amidine derivatives as inhibitors of nitric oxide synthetase
BR9509297A (pt) * 1995-08-10 1998-07-07 Astra Ab Composto composição farmacêutica utilização de um composto e processos de tratamento ou prolifaxia de uma doença ou condição na qual a síntese ou suprasintese da sintetase de óxido nitrico forma uma parte contribuinte e desordens neurodegenerativas ou de enxaqueca ou de prevenção e reversão da tolerância a opiatos e diazepinas ou de tratamento do vicio em tóxicos e de preparação de um composto

Also Published As

Publication number Publication date
SK140699A3 (en) 2000-06-12
AR012602A1 (es) 2000-11-08
NZ500676A (en) 2001-05-25
ID23156A (id) 2000-03-23
JP2001523263A (ja) 2001-11-20
PT983266E (pt) 2002-05-31
DK0983266T3 (da) 2002-03-11
AU734394B2 (en) 2001-06-14
SE9701682D0 (sv) 1997-05-05
AU7460098A (en) 1998-11-27
EP0983266A1 (de) 2000-03-08
MXPA99009874A (es) 2004-09-30
US6166030A (en) 2000-12-26
ES2168757T3 (es) 2002-06-16
EP0983266B1 (de) 2001-12-12
ATE210661T1 (de) 2001-12-15
DE69802923D1 (de) 2002-01-24
TR199902719T2 (xx) 2000-02-21
BR9808725A (pt) 2000-07-11
CN1255130A (zh) 2000-05-31
EE9900475A (et) 2000-06-15
KR20010012227A (ko) 2001-02-15
IL132677A0 (en) 2001-03-19
HUP0003766A3 (en) 2001-09-28
NO995404D0 (no) 1999-11-04
NO995404L (no) 2000-01-05
HUP0003766A2 (en) 2001-03-28
PL336854A1 (en) 2000-07-17
DE69802923T2 (de) 2002-07-04
IS5237A (is) 1999-11-01
CA2287999A1 (en) 1998-11-12
WO1998050380A1 (en) 1998-11-12

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