ZA852864B - Preparation of functional human factor viii - Google Patents

Preparation of functional human factor viii

Info

Publication number: ZA852864B
Authority: ZA; South Africa
Prior art keywords: preparation; factor viii; human factor; functional human; functional
Prior art date: 1984-04-20

Application number

ZA852864A

Other languages

English (en)

Inventor

Daniel Jeffrey Capon

Richard Mark Lawn

Gordon Allen Vehar

William Irwin Wood

Original Assignee

Genentech Inc

Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)

1984-04-20

Filing date

1985-04-17

Publication date

1986-12-30

Family has litigation

First worldwide family litigation filed litigation Critical https://patents.darts-ip.com/?family=24410850&utm_source=google_patent&utm_medium=platform_link&utm_campaign=public_patent_search&patent=ZA852864(B) "Global patent litigation dataset” by Darts-ip is licensed under a Creative Commons Attribution 4.0 International License.

1985-04-17 Application filed by Genentech Inc filed Critical Genentech Inc

1986-12-30 Publication of ZA852864B publication Critical patent/ZA852864B/xx

Links

101000911390 Homo sapiens Coagulation factor VIII Proteins 0.000 title 1
102000057593 human F8 Human genes 0.000 title 1
229960000900 human factor viii Drugs 0.000 title 1

Classifications

- C—CHEMISTRY; METALLURGY
- C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
- C12N—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
- C12N15/00—Mutation or genetic engineering; DNA or RNA concerning genetic engineering, vectors, e.g. plasmids, or their isolation, preparation or purification; Use of hosts therefor
- C—CHEMISTRY; METALLURGY
- C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
- C12N—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
- C12N15/00—Mutation or genetic engineering; DNA or RNA concerning genetic engineering, vectors, e.g. plasmids, or their isolation, preparation or purification; Use of hosts therefor
- C12N15/09—Recombinant DNA-technology
- C12N15/10—Processes for the isolation, preparation or purification of DNA or RNA
- C12N15/1034—Isolating an individual clone by screening libraries
- C12N15/1051—Gene trapping, e.g. exon-, intron-, IRES-, signal sequence-trap cloning, trap vectors
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P7/00—Drugs for disorders of the blood or the extracellular fluid
- A61P7/04—Antihaemorrhagics; Procoagulants; Haemostatic agents; Antifibrinolytic agents
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07K—PEPTIDES
- C07K14/00—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof
- C07K14/435—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from animals; from humans
- C07K14/745—Blood coagulation or fibrinolysis factors
- C07K14/755—Factors VIII, e.g. factor VIII C (AHF), factor VIII Ag (VWF)
- C—CHEMISTRY; METALLURGY
- C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
- C12N—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
- C12N15/00—Mutation or genetic engineering; DNA or RNA concerning genetic engineering, vectors, e.g. plasmids, or their isolation, preparation or purification; Use of hosts therefor
- C12N15/09—Recombinant DNA-technology
- C12N15/63—Introduction of foreign genetic material using vectors; Vectors; Use of hosts therefor; Regulation of expression
- C12N15/79—Vectors or expression systems specially adapted for eukaryotic hosts
- C12N15/85—Vectors or expression systems specially adapted for eukaryotic hosts for animal cells
- C—CHEMISTRY; METALLURGY
- C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
- C12Q—MEASURING OR TESTING PROCESSES INVOLVING ENZYMES, NUCLEIC ACIDS OR MICROORGANISMS; COMPOSITIONS OR TEST PAPERS THEREFOR; PROCESSES OF PREPARING SUCH COMPOSITIONS; CONDITION-RESPONSIVE CONTROL IN MICROBIOLOGICAL OR ENZYMOLOGICAL PROCESSES
- C12Q1/00—Measuring or testing processes involving enzymes, nucleic acids or microorganisms; Compositions therefor; Processes of preparing such compositions
- C12Q1/68—Measuring or testing processes involving enzymes, nucleic acids or microorganisms; Compositions therefor; Processes of preparing such compositions involving nucleic acids
- C12Q1/6813—Hybridisation assays
- C12Q1/6832—Enhancement of hybridisation reaction
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K38/00—Medicinal preparations containing peptides
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07K—PEPTIDES
- C07K2319/00—Fusion polypeptide
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07K—PEPTIDES
- C07K2319/00—Fusion polypeptide
- C07K2319/01—Fusion polypeptide containing a localisation/targetting motif
- C07K2319/02—Fusion polypeptide containing a localisation/targetting motif containing a signal sequence
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07K—PEPTIDES
- C07K2319/00—Fusion polypeptide
- C07K2319/80—Fusion polypeptide containing a DNA binding domain, e.g. Lacl or Tet-repressor
- C—CHEMISTRY; METALLURGY
- C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
- C12N—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
- C12N2800/00—Nucleic acids vectors
- C12N2800/10—Plasmid DNA
- C12N2800/108—Plasmid DNA episomal vectors
- C—CHEMISTRY; METALLURGY
- C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
- C12N—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
- C12N2840/00—Vectors comprising a special translation-regulating system
- C12N2840/44—Vectors comprising a special translation-regulating system being a specific part of the splice mechanism, e.g. donor, acceptor
- Y—GENERAL TAGGING OF NEW TECHNOLOGICAL DEVELOPMENTS; GENERAL TAGGING OF CROSS-SECTIONAL TECHNOLOGIES SPANNING OVER SEVERAL SECTIONS OF THE IPC; TECHNICAL SUBJECTS COVERED BY FORMER USPC CROSS-REFERENCE ART COLLECTIONS [XRACs] AND DIGESTS
- Y02—TECHNOLOGIES OR APPLICATIONS FOR MITIGATION OR ADAPTATION AGAINST CLIMATE CHANGE
- Y02A—TECHNOLOGIES FOR ADAPTATION TO CLIMATE CHANGE
- Y02A50/00—TECHNOLOGIES FOR ADAPTATION TO CLIMATE CHANGE in human health protection, e.g. against extreme weather
- Y02A50/30—Against vector-borne diseases, e.g. mosquito-borne, fly-borne, tick-borne or waterborne diseases whose impact is exacerbated by climate change

Landscapes

Health & Medical Sciences (AREA)
Chemical & Material Sciences (AREA)
Life Sciences & Earth Sciences (AREA)
Genetics & Genomics (AREA)
Organic Chemistry (AREA)
Engineering & Computer Science (AREA)
Zoology (AREA)
Wood Science & Technology (AREA)
Bioinformatics & Cheminformatics (AREA)
General Engineering & Computer Science (AREA)
Biotechnology (AREA)
Biomedical Technology (AREA)
General Health & Medical Sciences (AREA)
Biochemistry (AREA)
Molecular Biology (AREA)
Biophysics (AREA)
Microbiology (AREA)
Physics & Mathematics (AREA)
Proteomics, Peptides & Aminoacids (AREA)
Plant Pathology (AREA)
Chemical Kinetics & Catalysis (AREA)
Medicinal Chemistry (AREA)
Hematology (AREA)
Diabetes (AREA)
Immunology (AREA)
Public Health (AREA)
Analytical Chemistry (AREA)
Animal Behavior & Ethology (AREA)
Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
Gastroenterology & Hepatology (AREA)
Pharmacology & Pharmacy (AREA)
Toxicology (AREA)
Veterinary Medicine (AREA)
General Chemical & Material Sciences (AREA)
Bioinformatics & Computational Biology (AREA)
Crystallography & Structural Chemistry (AREA)
Preparation Of Compounds By Using Micro-Organisms (AREA)
Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)
Micro-Organisms Or Cultivation Processes Thereof (AREA)
Peptides Or Proteins (AREA)

ZA852864A 1984-04-20 1985-04-17 Preparation of functional human factor viii ZA852864B (en)

Applications Claiming Priority (1)

Application Number	Priority Date	Filing Date	Title
US60231284A	1984-04-20	1984-04-20

Publications (1)

Publication Number	Publication Date
ZA852864B true ZA852864B (en)	1986-12-30

Family

ID=24410850

Family Applications (1)

Application Number	Title	Priority Date	Filing Date
ZA852864A ZA852864B (en)	1984-04-20	1985-04-17	Preparation of functional human factor viii

Country Status (23)

Country	Link
EP (2)	EP0385558A3 (no)
JP (2)	JP2799338B2 (no)
KR (1)	KR850007275A (no)
AR (1)	AR241314A1 (no)
AT (1)	ATE60087T1 (no)
AU (2)	AU601358B2 (no)
CA (2)	CA1341395C (no)
DE (1)	DE3581312D1 (no)
DK (1)	DK164876C (no)
ES (1)	ES8607397A1 (no)
FI (1)	FI86885C (no)
GR (1)	GR850947B (no)
HK (1)	HK8395A (no)
HU (1)	HU202275B (no)
IE (1)	IE57677B1 (no)
IL (1)	IL74909A (no)
LU (1)	LU88546I2 (no)
MY (1)	MY102029A (no)
NL (1)	NL940016I2 (no)
NO (1)	NO174934C (no)
NZ (1)	NZ211824A (no)
PT (1)	PT80292B (no)
ZA (1)	ZA852864B (no)

Families Citing this family (67)

* Cited by examiner, † Cited by third party
Publication number	Priority date	Publication date	Assignee	Title
US4657894A (en) *	1983-03-31	1987-04-14	Scripps Clinic & Research Foundation	New factor VIII coagulant polypeptides
WO1985001961A1 (en) *	1983-10-28	1985-05-09	Genetics Institute	Production of factor viii and related products
US7138505B1 (en)	1984-01-12	2006-11-21	Novartis Vaccines And Diagnostics, Inc.	Factor VIII:C nucleic acid molecules
ATE224445T1 (de) *	1984-01-12	2002-10-15	Chiron Corp	Für faktor-viiic kodierende dna-sequenzen und verwandte dna-konstruktionen
US5045455A (en) *	1984-01-12	1991-09-03	Chiron Corporation	Factor VIII:C cDNA cloning and expression
US4716117A (en) *	1984-10-26	1987-12-29	Chiron Corporation	Monoclonal antibodies to factor VIIIC
US5004804A (en) *	1984-01-12	1991-04-02	Nordisk Gentofte	Method and composition for preparation of factor VIIIC
ZA852099B (en) *	1984-03-26	1985-12-24	Meloy Lab	Recombinant factor viii-c.
FI86885C (fi)	1984-04-20	1992-10-26	Genentech Inc	Foerfarande foer framstaellning av human rekombinantfaktor viii och nukleinsyrasekvenser och vektorer anvaend daertill
EP0182448A3 (en) *	1984-08-24	1987-10-28	Genetics Institute, Inc.	Production of factor viii and related products
WO1986006101A1 (en) *	1985-04-12	1986-10-23	Genetics Institute, Inc.	Novel procoagulant proteins
US5198349A (en) *	1986-01-03	1993-03-30	Genetics Institute, Inc.	Method for producing factor VIII:C and analogs
US5595886A (en)	1986-01-27	1997-01-21	Chiron Corporation	Protein complexes having Factor VIII:C activity and production thereof
EP0251843A1 (fr) *	1986-06-06	1988-01-07	Transgene S.A.	Procédé de préparation de facteur VIII à partir de cellules de mammifères
FR2599754B1 (fr) *	1986-06-06	1989-12-29	Transgene Sa	Procede de preparation de facteur viii a partir de cellules de mammiferes
EP0254076B1 (en) *	1986-07-11	1991-05-08	Miles Inc.	Improved recombinant protein production
NO872932L (no) *	1986-07-18	1988-01-19	Gist Brocades Nv	Fremgangsmaate for fremstilling av proteiner med faktorviiiaktivitet ved hjelp av mikrobielle vertsceller, eksprimeringsvektorer, vertsceller, antibiotika.
FR2603899B1 (fr) *	1986-09-12	1990-07-13	Genentech Inc	Procede perfectionne pour l'expression de recombinants
WO1988005825A1 (en) *	1987-01-30	1988-08-11	Biogen N.V.	A method for producing factor viii in high yield
US6060447A (en) *	1987-05-19	2000-05-09	Chiron Corporation	Protein complexes having Factor VIII:C activity and production thereof
EP0294910B1 (en) *	1987-06-12	1996-09-11	Immuno Ag	Novel proteins with factor VIII activity, process for their preparation using genetically engineered cells and pharmaceutical compositions containing them
US6346513B1 (en)	1987-06-12	2002-02-12	Baxter Trading Gmbh	Proteins with factor VIII activity: process for their preparation using genetically-engineered cells and pharmaceutical compositions containing them
IE69026B1 (en) *	1987-06-12	1996-08-07	Immuno Ag	Novel proteins with factor VIII activity process for their preparation using genetically-engineered cells and pharmaceutical compositions containing them
JPH0387173A (ja) *	1987-09-10	1991-04-11	Teijin Ltd	ヒト活性化天然型ファクター８ｃの製造方法及びそれに用いる形質転換体
JP2791418B2 (ja)	1987-12-02	1998-08-27	株式会社ミドリ十字	異種蛋白質の製造方法、組換えｄｎａ、形質転換体
FR2642767B1 (fr) *	1989-01-19	1993-10-01	Transgene Sa	Vecteurs d'expression de proteines heterologues dans les cellules eucaryotes, lignees cellulaires obtenues et procede pour leur preparation
NZ237244A (en) *	1990-03-02	1992-10-28	Bio Technology General Corp	Cloning and production of human von willebrand factor analogues and compositions thereof
US6008193A (en) *	1990-03-02	1999-12-28	Bio-Technology General Corp.	Methods of using human von Willebrand factor GPIb binding domain polypeptides
US5849536A (en) *	1990-03-02	1998-12-15	Bio-Technology General Corp.	Cloning and production of human von willebrand factor GPIb binding domain polypeptides and methods of using same
US5279956A (en) *	1991-06-24	1994-01-18	The Scripps Research Institute	Activated protein C polypeptides and anti-peptide antibodies, diagnostic methods and systems for inhibiting activated protein C
DK53792D0 (da) *	1992-04-24	1992-04-24	Novo Nordisk As	Fremgangsmaade til fremstilling af proteiner
SE504074C2 (sv) *	1993-07-05	1996-11-04	Pharmacia Ab	Proteinberedning för subkutan, intramuskulär eller intradermal administrering
SE9303601D0 (sv) *	1993-11-01	1993-11-01	Kabi Pharmacia Ab	Improved cell cultivation method and medium
US6288030B1 (en)	1993-12-22	2001-09-11	Amgen Inc.	Stem cell factor formulations and methods
IL113010A (en) *	1994-03-31	1999-10-28	Pharmacia & Upjohn Ab	Pharmaceutical formulation comprising factor viii with an activity of at least 500iu/ml and an enhancer for improved subcutaneous intramuscular or intradermal administration
US5561053A (en) *	1994-08-05	1996-10-01	Genentech, Inc.	Method for selecting high-expressing host cells
SE503424C2 (sv) *	1994-11-14	1996-06-10	Pharmacia Ab	Process för rening av rekombinant koagulationsfaktor VIII
SE9403915D0 (sv) *	1994-11-14	1994-11-14	Annelie Almstedt	Process A
GB9501040D0 (en)	1995-01-19	1995-03-08	Quadrant Holdings Cambridge	Dried composition
US6020473A (en) *	1995-08-25	2000-02-01	Genentech, Inc.	Nucleic acids encoding variants of vascular endothelial cell growth factor
US7005505B1 (en)	1995-08-25	2006-02-28	Genentech, Inc.	Variants of vascular endothelial cell growth factor
US5910481A (en) *	1995-11-13	1999-06-08	Immuno Ag	Hybrid proteins with modified activity
AT405740B (de) *	1996-12-13	1999-11-25	Immuno Ag	Von willebrand-faktor-derivat sowie ein verfahren zur isolierung von proteinen
US6475725B1 (en)	1997-06-20	2002-11-05	Baxter Aktiengesellschaft	Recombinant cell clones having increased stability and methods of making and using the same
US6221349B1 (en)	1998-10-20	2001-04-24	Avigen, Inc.	Adeno-associated vectors for expression of factor VIII by target cells
US6200560B1 (en)	1998-10-20	2001-03-13	Avigen, Inc.	Adeno-associated virus vectors for expression of factor VIII by target cells
SE9901379D0 (sv)	1999-04-19	1999-04-19	Pharmacia & Upjohn Ab	Receptor structures
AT409379B (de)	1999-06-02	2002-07-25	Baxter Ag	Medium zur protein- und serumfreien kultivierung von zellen
JP4663837B2 (ja) *	1999-12-24	2011-04-06	一般財団法人化学及血清療法研究所	第▲ｖｉｉｉ▼因子を主成分とする血小板減少に伴う出血疾患の予防・治療用医薬組成物
AU5471501A (en) *	2000-03-22	2001-10-03	Octagene Gmbh	Production of recombinant blood clotting factors in human cell lines
EP1418810A4 (en)	2001-08-03	2006-08-02	Us Gov Health & Human Serv	TREATMENT OF HEMOPHILIA ORAL
EP1453966B1 (en) *	2001-11-28	2012-07-11	Sandoz AG	Method for producing a recombinant polypeptide
EP2287288B1 (en)	2002-07-09	2012-11-07	Baxter International Inc.	Animal protein free media for cultivation of cells
HUE035567T2 (en)	2003-09-30	2018-05-28	Univ Pennsylvania	Adeno-associated virus (AAV) clusters, sequences, vectors and applications containing them
US20060094104A1 (en)	2004-10-29	2006-05-04	Leopold Grillberger	Animal protein-free media for cultivation of cells
EP1707634A1 (en)	2005-03-29	2006-10-04	Octapharma AG	Method for isolation of recombinantly produced proteins
DE23193606T1 (de)	2005-04-07	2024-02-15	The Trustees Of The University Of Pennsylvania	Verfahren zur erhöhung der funktion eines aav-vektors
EP1739179A1 (en)	2005-06-30	2007-01-03	Octapharma AG	Serum-free stable transfection and production of recombinant human proteins in human cell lines
CN101360820A (zh)	2006-01-04	2009-02-04	巴克斯特国际公司	无寡肽的细胞培养基
WO2011095604A1 (en)	2010-02-04	2011-08-11	Octapharma Biopharmaceuticals Gmbh	Half-life prolongation of proteins
SG183929A1 (en)	2010-03-29	2012-10-30	Univ Pennsylvania	Pharmacologically induced transgene ablation system
US9315825B2 (en)	2010-03-29	2016-04-19	The Trustees Of The University Of Pennsylvania	Pharmacologically induced transgene ablation system
CA2826316C (en)	2011-02-17	2021-04-27	The Trustees Of The University Of Pennsylvania	Compositions and methods for altering tissue specificity and improving aav9-mediated gene transfer
US9719106B2 (en)	2013-04-29	2017-08-01	The Trustees Of The University Of Pennsylvania	Tissue preferential codon modified expression cassettes, vectors containing same, and uses thereof
US10058624B2 (en)	2015-04-16	2018-08-28	Emory University	Recombinant promoters and vectors for protein expression in liver and use thereof
CN111504887B (zh) *	2020-05-09	2023-05-09	苏州四正柏生物科技有限公司	一种溶血素及其制备方法
US20240043494A1 (en)	2020-08-07	2024-02-08	Amicus Therapeutics, Inc.	Vesicle Targeting Proteins And Uses Of Same

Family Cites Families (8)

* Cited by examiner, † Cited by third party
Publication number	Priority date	Publication date	Assignee	Title
US4361509A (en) *	1981-12-14	1982-11-30	Scripps Clinic And Research Foundation	Ultrapurification of factor VIII using monoclonal antibodies
WO1984000560A1 (en) *	1982-08-04	1984-02-16	Nat Res Dev	Molecular cloning of the gene for human anti-haemophilic factor ix
CA1341506C (en) *	1983-03-31	2006-06-06	Theodore S. Zimmerman	Factor viii coagulant polypeptides and monoclonal antibodies to them
WO1985001961A1 (en) *	1983-10-28	1985-05-09	Genetics Institute	Production of factor viii and related products
ATE224445T1 (de) *	1984-01-12	2002-10-15	Chiron Corp	Für faktor-viiic kodierende dna-sequenzen und verwandte dna-konstruktionen
ZA852099B (en) *	1984-03-26	1985-12-24	Meloy Lab	Recombinant factor viii-c.
FI86885C (fi)	1984-04-20	1992-10-26	Genentech Inc	Foerfarande foer framstaellning av human rekombinantfaktor viii och nukleinsyrasekvenser och vektorer anvaend daertill
JPS60224492A (ja) *	1984-04-24	1985-11-08	Yuu Honshiyo	異種遺伝子の結合法

1985
- 1985-04-15 FI FI851497A patent/FI86885C/fi not_active IP Right Cessation
- 1985-04-15 IL IL74909A patent/IL74909A/xx not_active IP Right Cessation
- 1985-04-16 PT PT80292A patent/PT80292B/pt unknown
- 1985-04-16 ES ES542296A patent/ES8607397A1/es not_active Expired
- 1985-04-16 AR AR85300095A patent/AR241314A1/es active
- 1985-04-17 NZ NZ211824A patent/NZ211824A/en unknown
- 1985-04-17 AU AU41345/85A patent/AU601358B2/en not_active Expired
- 1985-04-17 ZA ZA852864A patent/ZA852864B/xx unknown
- 1985-04-17 CA CA000617007A patent/CA1341395C/en not_active Expired - Fee Related
- 1985-04-17 HU HU851428A patent/HU202275B/hu unknown
- 1985-04-17 CA CA000479409A patent/CA1341468C/en not_active Expired - Fee Related
- 1985-04-18 EP EP19900200797 patent/EP0385558A3/en not_active Withdrawn
- 1985-04-18 NO NO851563A patent/NO174934C/no not_active IP Right Cessation
- 1985-04-18 IE IE998/85A patent/IE57677B1/en not_active IP Right Cessation
- 1985-04-18 AT AT85302734T patent/ATE60087T1/de active
- 1985-04-18 GR GR850947A patent/GR850947B/el not_active IP Right Cessation
- 1985-04-18 LU LU88546C patent/LU88546I2/fr unknown
- 1985-04-18 DE DE8585302734T patent/DE3581312D1/de not_active Expired - Lifetime
- 1985-04-18 EP EP85302734A patent/EP0160457B1/en not_active Expired - Lifetime
- 1985-04-19 JP JP60085295A patent/JP2799338B2/ja not_active Expired - Lifetime
- 1985-04-19 KR KR1019850002651A patent/KR850007275A/ko not_active Application Discontinuation
- 1985-04-19 DK DK176885A patent/DK164876C/da not_active IP Right Cessation
1987
- 1987-09-24 MY MYPI87001923A patent/MY102029A/en unknown
1990
- 1990-04-05 AU AU52958/90A patent/AU5295890A/en not_active Abandoned
1993
- 1993-04-20 JP JP5093222A patent/JP2777043B2/ja not_active Expired - Lifetime
1994
- 1994-08-24 NL NL940016C patent/NL940016I2/nl unknown
1995
- 1995-01-19 HK HK8395A patent/HK8395A/xx not_active IP Right Cessation

Also Published As

Publication number	Publication date
FI86885C (fi)	1992-10-26
IE57677B1 (en)	1993-02-24
CA1341468C (en)	2004-12-14
DE3581312D1 (de)	1991-02-21
AU4134585A (en)	1985-10-24
FI851497L (fi)	1985-10-21
EP0385558A3 (en)	1990-12-27
LU88546I2 (fr)	1995-03-01
JP2799338B2 (ja)	1998-09-17
DK176885A (da)	1985-10-21
JP2777043B2 (ja)	1998-07-16
DK164876B (da)	1992-08-31
NO851563L (no)	1985-10-21
HK8395A (en)	1995-01-27
EP0385558A2 (en)	1990-09-05
NZ211824A (en)	1991-05-28
ES542296A0 (es)	1986-06-01
IL74909A (en)	1992-01-15
IL74909A0 (en)	1985-07-31
DK176885D0 (da)	1985-04-19
HU202275B (en)	1991-02-28
GR850947B (no)	1985-07-17
JPS60243023A (ja)	1985-12-03
HUT37654A (en)	1986-01-23
PT80292B (pt)	1987-10-20
ATE60087T1 (de)	1991-02-15
NO174934B (no)	1994-04-25
FI86885B (fi)	1992-07-15
NO174934C (no)	1994-08-03
PT80292A (en)	1985-05-01
AR241314A1 (es)	1992-05-29
EP0160457B1 (en)	1991-01-16
MY102029A (en)	1992-02-29
NL940016I2 (nl)	2000-08-01
AU601358B2 (en)	1990-09-13
JPH0640942A (ja)	1994-02-15
AU5295890A (en)	1990-08-30
CA1341395C (en)	2002-10-22
IE850998L (en)	1985-10-20
ES8607397A1 (es)	1986-06-01
NL940016I1 (nl)	1994-10-17
DK164876C (da)	1993-01-18
EP0160457A1 (en)	1985-11-06
FI851497A0 (fi)	1985-04-15
KR850007275A (ko)	1985-12-02

Publication	Publication Date	Title
PT80292A (en)	1985-05-01	Preparation of functional human factor viii
IL75533A0 (en)	1985-10-31	Preparation of heteroaryloxyacetamides
IL83663A0 (en)	1988-01-31	Preparation of 3-pyrrolidinols
IL74661A0 (en)	1985-06-30	Preparation of proteins
GB8725334D0 (en)	1987-12-02	Preparation of benzothiazole-2-sulphenamides
EP0295361A3 (en)	1990-01-24	Preparation of pseudoionones
GB8507789D0 (en)	1985-05-01	Preparation of 2-amino-s-triazines
IL76249A0 (en)	1986-01-31	Preparation of fluoroformates
GB8727401D0 (en)	1987-12-23	Preparation of trifluoromethylbenzonitrile
IL82218A (en)	1991-07-18	Preparation of 1-aryl-5-amino-pyrazoles
IL85656A0 (en)	1988-08-31	Preparation of phenylacetaldehydes
DE3566540D1 (en)	1989-01-05	Preparation of fluoropyridines
IL82217A0 (en)	1987-10-30	Preparation of 1-aryl-5-amino-pyrazoles
GB2196961B (en)	1990-08-08	Preparation of polyfluoroenolates
IL76216A0 (en)	1986-01-31	Preparation of sulphonylisoureas and-thioureas
GB8422162D0 (en)	1984-10-03	Preparation of alkyfurans
GB8520403D0 (en)	1985-09-18	Preparation of aminolactone
IL93200A0 (en)	1990-11-05	Preparation of functional human factor viii
IL93201A0 (en)	1990-11-05	Preparation of functional human factor viii
IL84778A (en)	1992-02-16	Preparation of mercaptobenzoates
GB8703882D0 (en)	1987-03-25	Preparation of encainide
GB2201674B (en)	1991-01-02	Preparation of triperfluoroalkylamines
IL83517A (en)	1991-07-18	Preparation of n-cyano-methylarylcarboxamides
IL82018A0 (en)	1987-10-20	Preparation of 4-nitrophenetol
IE841535L (en)	1984-12-20	Preparation of 3-substituted-3-aminonitrile