ZA832883B - N-alkylnorscopines and their preparation - Google Patents

N-alkylnorscopines and their preparation

Info

Publication number: ZA832883B
Authority: ZA; South Africa
Prior art keywords: alkylnorscopines; preparation; alkylnorscopolamines; hydrogenolysis; ethanol
Prior art date: 1982-04-26

Application number

ZA832883A

Other languages

English (en)

Inventor

Rolf Banholzer

Original Assignee

Boehringer Ingelheim Int

Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)

1982-04-26

Filing date

1983-04-25

Publication date

1984-12-24

1983-04-25 Application filed by Boehringer Ingelheim Int filed Critical Boehringer Ingelheim Int

1984-12-24 Publication of ZA832883B publication Critical patent/ZA832883B/xx

Links

LFQSCWFLJHTTHZ-UHFFFAOYSA-N Ethanol Chemical compound CCO LFQSCWFLJHTTHZ-UHFFFAOYSA-N 0.000 abstract 2
125000000217 alkyl group Chemical group 0.000 abstract 1
125000004432 carbon atom Chemical group C* 0.000 abstract 1
238000006243 chemical reaction Methods 0.000 abstract 1
150000001875 compounds Chemical class 0.000 abstract 1
150000004678 hydrides Chemical class 0.000 abstract 1
238000007327 hydrogenolysis reaction Methods 0.000 abstract 1
239000008194 pharmaceutical composition Substances 0.000 abstract 1
229910000033 sodium borohydride Inorganic materials 0.000 abstract 1
239000012279 sodium borohydride Substances 0.000 abstract 1

Classifications

- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D451/00—Heterocyclic compounds containing 8-azabicyclo [3.2.1] octane, 9-azabicyclo [3.3.1] nonane, or 3-oxa-9-azatricyclo [3.3.1.0<2,4>] nonane ring systems, e.g. tropane or granatane alkaloids, scopolamine; Cyclic acetals thereof
- C07D451/02—Heterocyclic compounds containing 8-azabicyclo [3.2.1] octane, 9-azabicyclo [3.3.1] nonane, or 3-oxa-9-azatricyclo [3.3.1.0<2,4>] nonane ring systems, e.g. tropane or granatane alkaloids, scopolamine; Cyclic acetals thereof containing not further condensed 8-azabicyclo [3.2.1] octane or 3-oxa-9-azatricyclo [3.3.1.0<2,4>] nonane ring systems, e.g. tropane; Cyclic acetals thereof
- C07D451/04—Heterocyclic compounds containing 8-azabicyclo [3.2.1] octane, 9-azabicyclo [3.3.1] nonane, or 3-oxa-9-azatricyclo [3.3.1.0<2,4>] nonane ring systems, e.g. tropane or granatane alkaloids, scopolamine; Cyclic acetals thereof containing not further condensed 8-azabicyclo [3.2.1] octane or 3-oxa-9-azatricyclo [3.3.1.0<2,4>] nonane ring systems, e.g. tropane; Cyclic acetals thereof with hetero atoms directly attached in position 3 of the 8-azabicyclo [3.2.1] octane or in position 7 of the 3-oxa-9-azatricyclo [3.3.1.0<2,4>] nonane ring system
- C07D451/06—Oxygen atoms
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P11/00—Drugs for disorders of the respiratory system
- A61P11/08—Bronchodilators
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P25/00—Drugs for disorders of the nervous system
- A61P25/02—Drugs for disorders of the nervous system for peripheral neuropathies
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P43/00—Drugs for specific purposes, not provided for in groups A61P1/00-A61P41/00

Landscapes

Chemical & Material Sciences (AREA)
Organic Chemistry (AREA)
Health & Medical Sciences (AREA)
Veterinary Medicine (AREA)
Chemical Kinetics & Catalysis (AREA)
General Chemical & Material Sciences (AREA)
Medicinal Chemistry (AREA)
Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
Bioinformatics & Cheminformatics (AREA)
Pharmacology & Pharmacy (AREA)
Life Sciences & Earth Sciences (AREA)
Animal Behavior & Ethology (AREA)
General Health & Medical Sciences (AREA)
Public Health (AREA)
Engineering & Computer Science (AREA)
Neurology (AREA)
Biomedical Technology (AREA)
Neurosurgery (AREA)
Pulmonology (AREA)
Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
Hydrogenated Pyridines (AREA)
Organic Low-Molecular-Weight Compounds And Preparation Thereof (AREA)
Nitrogen And Oxygen Or Sulfur-Condensed Heterocyclic Ring Systems (AREA)
Nitrogen Condensed Heterocyclic Rings (AREA)
Compositions Of Macromolecular Compounds (AREA)
Low-Molecular Organic Synthesis Reactions Using Catalysts (AREA)
Mushroom Cultivation (AREA)
Preparation Of Fruits And Vegetables (AREA)
Saccharide Compounds (AREA)

ZA832883A 1982-04-26 1983-04-25 N-alkylnorscopines and their preparation ZA832883B (en)

Applications Claiming Priority (1)

Application Number	Priority Date	Filing Date	Title
DE19823215493 DE3215493A1 (de)	1982-04-26	1982-04-26	Neue zwischenprodukte, verfahren zu ihrer herstellung und ihre verwendung

Publications (1)

Publication Number	Publication Date
ZA832883B true ZA832883B (en)	1984-12-24

Family

ID=6161961

Family Applications (1)

Application Number	Title	Priority Date	Filing Date
ZA832883A ZA832883B (en)	1982-04-26	1983-04-25	N-alkylnorscopines and their preparation

Country Status (24)

Country	Link
US (1)	US4783534A (xx)
EP (1)	EP0092814B1 (xx)
JP (1)	JPS58201779A (xx)
KR (1)	KR900004127B1 (xx)
AT (1)	ATE16185T1 (xx)
AU (1)	AU557680B2 (xx)
CA (1)	CA1254566A (xx)
CS (1)	CS236873B2 (xx)
DD (1)	DD211114A5 (xx)
DE (2)	DE3215493A1 (xx)
DK (1)	DK159777C (xx)
ES (1)	ES521809A0 (xx)
FI (1)	FI831234L (xx)
GR (1)	GR78837B (xx)
HU (1)	HU193161B (xx)
IE (1)	IE55308B1 (xx)
IL (1)	IL68479A0 (xx)
NO (1)	NO159172C (xx)
NZ (1)	NZ203980A (xx)
PH (1)	PH23301A (xx)
PL (1)	PL138718B1 (xx)
PT (1)	PT76584B (xx)
YU (1)	YU43731B (xx)
ZA (1)	ZA832883B (xx)

Families Citing this family (33)

* Cited by examiner, † Cited by third party
Publication number	Priority date	Publication date	Assignee	Title
DE4021847C2 (de) *	1990-07-09	1994-09-08	Stockhausen Chem Fab Gmbh	Verfahren zur Herstellung wasserquellbarer Produkte unter Verwendung von Feinstanteilen wasserquellbarer Polymerer
PL362868A1 (en) *	2000-04-27	2004-11-02	Boehringer Ingelheim Pharma Gmbh & Co.Kg	Novel, slow-acting betamimetics, a method for their production and their use as medicaments
OA12522A (en) *	2000-10-12	2006-05-30	Boehringer Ingelheim Pharma	Novel tiotropium-containing inhalation powder.
US6908928B2 (en)	2000-10-12	2005-06-21	Bi Pharma Kg.	Crystalline tiotropium bromide monohydrate, processes for the preparation thereof, and pharmaceutical compositions
US6852728B2 (en) *	2000-10-14	2005-02-08	Boehringer Ingelheim Pharma Gmbh & Co. Kg	Anticholinergics, processes for preparing them, and pharmaceutical compositions containing them
US6706726B2 (en) *	2000-10-14	2004-03-16	Boehringer Ingelheim Pharma Gmbh & Co. Kg	Anticholinergics which may be used as medicaments as well as processes for preparing them
US20020151541A1 (en) *	2000-10-31	2002-10-17	Michel Pairet	Pharmaceutical compositions containing tiotropium salts and antihistamines and their use
US20020137764A1 (en) *	2000-10-31	2002-09-26	Karin Drechsel	Inhalable formulation of a solution containing a tiotropium salt
US20020111363A1 (en) *	2000-10-31	2002-08-15	Karin Drechsel	Inhalable formulation of a solution containing a tiotropium salt
US7776315B2 (en) *	2000-10-31	2010-08-17	Boehringer Ingelheim Pharma Gmbh & Co. Kg	Pharmaceutical compositions based on anticholinergics and additional active ingredients
DE10062712A1 (de) *	2000-12-15	2002-06-20	Boehringer Ingelheim Pharma	Neue Arzneimittelkompositionen auf der Basis von Anticholinergika und Corticosteroiden
US20020193392A1 (en) *	2000-11-13	2002-12-19	Christel Schmelzer	Pharmaceutical compositions based on tiotropium salts of salts of salmeterol
US20100310477A1 (en) *	2000-11-28	2010-12-09	Boehringer Ingelheim Pharma Gmbh & Co. Kg.	Pharmaceutical compositions based on anticholingerics and additional active ingredients
US20030013675A1 (en) *	2001-05-25	2003-01-16	Boehringer Ingelheim Pharma Kg	Combination of an adenosine A2A-receptor agonist and tiotropium or a derivative thereof for treating obstructive airways and other inflammatory diseases
US20030070679A1 (en) *	2001-06-01	2003-04-17	Boehringer Ingelheim Pharma Kg	Capsules containing inhalable tiotropium
US20030018019A1 (en) *	2001-06-23	2003-01-23	Boehringer Ingelheim Pharma Kg	Pharmaceutical compositions based on anticholinergics, corticosteroids and betamimetics
DE10141377A1 (de) *	2001-08-23	2003-03-13	Boehringer Ingelheim Pharma	Aufstreuverfahren zur Herstellung von Pulverformulierungen
US6919325B2 (en) *	2001-09-14	2005-07-19	Boehringer Ingelheim Pharma Kg	Pharmaceutical compositions containing tiotropium salts and low-solubility salmeterol salts
DE10200943A1 (de)	2002-01-12	2003-07-24	Boehringer Ingelheim Pharma	Verfahren zur Herstellung von Scopinestern
US6790856B2 (en) *	2002-01-31	2004-09-14	Boehringer Ingelheim Pharma Kg	Fluorenecarboxylic acid esters, process for the manufacture thereof, and use thereof as medicaments
US7405224B2 (en) *	2002-01-31	2008-07-29	Boehringer Ingelheim Pharma Gmbh & Co. Kg	Xanthenecarboxylates, processes for preparing them, and their use as pharmaceutical compositions
US7309707B2 (en) *	2002-03-20	2007-12-18	Boehringer Ingelheim Pharma Gmbh & Co. Kg	Crystalline micronisate, process for the manufacture thereof and use thereof for the preparation of a medicament
US7311894B2 (en) *	2002-03-28	2007-12-25	Boehringer Ingelheim Pharma Gmbh & Co. Kg	HFA suspension formulations containing an anticholinergic
US7244415B2 (en) *	2002-03-28	2007-07-17	Boehringer Ingelheim Pharma Gmbh & Co. Kg	HFA suspension formulations of an anhydrate
IL163736A0 (en) *	2002-04-04	2005-12-18	Boehringer Ingelheim Pharma	Powder formulations suitable for inhalation
US20030235538A1 (en) *	2002-04-09	2003-12-25	Boehringer Ingelheim Pharma Gmbh & Co. Kg	Method for the administration of an anticholinergic by inhalation
US7084153B2 (en) *	2002-04-12	2006-08-01	Boehringer Ingelheim Pharma Gmbh & Co. Kg	Medicaments comprising steroids and a novel anticholinergic
US7417051B2 (en) *	2002-04-12	2008-08-26	Boehringer Ingelheim Pharma Gmbh & Co. Kg	Medicaments comprising betamimetics and a novel anticholinergic
US7763280B2 (en) *	2002-11-28	2010-07-27	Boehringer Ingelheim Pharma Gmbh & Co. Kg	Tiotropium containing powder formulation for inhalation
DE10345065A1 (de) *	2003-09-26	2005-04-14	Boehringer Ingelheim Pharma Gmbh & Co. Kg	Aerosolformulierung für die Inhalation enthaltend ein Anticholinergikum
SE0303570L (sv) *	2003-12-03	2005-06-04	Microdrug Ag	Fukt-känslig medicinsk produkt
TWI274641B (en) *	2005-08-30	2007-03-01	Rexon Ind Corp Ltd	Cutting machine
CN115572291A (zh) *	2022-09-28	2023-01-06	成都第一制药有限公司	一种氢溴酸山莨菪碱及其制备方法和质量控制方法

Family Cites Families (1)

* Cited by examiner, † Cited by third party
Publication number	Priority date	Publication date	Assignee	Title
DE3211185A1 (de) *	1982-03-26	1983-09-29	Boehringer Ingelheim KG, 6507 Ingelheim	Neue quartaere 6,11-dihydro-dibenzo-(b,e)-thiepin-11-n-alkyl- norscopinether und verfahren zu deren herstellung

1982
- 1982-04-26 DE DE19823215493 patent/DE3215493A1/de not_active Withdrawn
1983
- 1983-04-13 FI FI831234A patent/FI831234L/fi not_active Application Discontinuation
- 1983-04-20 DD DD83250031A patent/DD211114A5/de not_active IP Right Cessation
- 1983-04-21 PT PT76584A patent/PT76584B/pt not_active IP Right Cessation
- 1983-04-21 GR GR71157A patent/GR78837B/el unknown
- 1983-04-22 AT AT83103935T patent/ATE16185T1/de not_active IP Right Cessation
- 1983-04-22 EP EP83103935A patent/EP0092814B1/de not_active Expired
- 1983-04-22 NZ NZ203980A patent/NZ203980A/en unknown
- 1983-04-22 DE DE8383103935T patent/DE3361054D1/de not_active Expired
- 1983-04-25 NO NO831447A patent/NO159172C/no unknown
- 1983-04-25 DK DK182583A patent/DK159777C/da active
- 1983-04-25 YU YU939/83A patent/YU43731B/xx unknown
- 1983-04-25 KR KR1019830001742A patent/KR900004127B1/ko not_active IP Right Cessation
- 1983-04-25 PL PL1983241635A patent/PL138718B1/pl unknown
- 1983-04-25 IE IE938/83A patent/IE55308B1/en not_active IP Right Cessation
- 1983-04-25 ZA ZA832883A patent/ZA832883B/xx unknown
- 1983-04-25 CA CA000426597A patent/CA1254566A/en not_active Expired
- 1983-04-25 HU HU831415A patent/HU193161B/hu not_active IP Right Cessation
- 1983-04-25 ES ES521809A patent/ES521809A0/es active Granted
- 1983-04-25 JP JP58072766A patent/JPS58201779A/ja active Granted
- 1983-04-25 IL IL68479A patent/IL68479A0/xx not_active IP Right Cessation
- 1983-04-25 CS CS832919A patent/CS236873B2/cs unknown
- 1983-04-26 AU AU13945/83A patent/AU557680B2/en not_active Ceased
1984
- 1984-08-13 PH PH31101A patent/PH23301A/en unknown
1987
- 1987-03-31 US US07/032,762 patent/US4783534A/en not_active Expired - Fee Related

Also Published As

Publication number	Publication date
DD211114A5 (de)	1984-07-04
ES8402292A1 (es)	1984-01-16
HU193161B (en)	1987-08-28
DK182583D0 (da)	1983-04-25
DK159777C (da)	1991-04-22
NO159172C (no)	1988-12-07
JPS58201779A (ja)	1983-11-24
DE3215493A1 (de)	1983-11-03
CS236873B2 (en)	1985-05-15
PT76584A (de)	1983-05-01
GR78837B (xx)	1984-10-02
DK182583A (da)	1983-10-27
PH23301A (en)	1989-06-30
NZ203980A (en)	1986-02-21
PT76584B (de)	1986-02-27
IL68479A0 (en)	1983-07-31
NO831447L (no)	1983-10-27
KR840004425A (ko)	1984-10-15
YU43731B (en)	1989-10-31
CA1254566A (en)	1989-05-23
EP0092814B1 (de)	1985-10-23
YU93983A (en)	1985-10-31
KR900004127B1 (ko)	1990-06-16
EP0092814A1 (de)	1983-11-02
NO159172B (no)	1988-08-29
PL241635A1 (en)	1983-11-21
DE3361054D1 (en)	1985-11-28
IE55308B1 (en)	1990-08-01
JPH052678B2 (xx)	1993-01-13
ES521809A0 (es)	1984-01-16
AU557680B2 (en)	1987-01-08
FI831234A0 (fi)	1983-04-13
FI831234L (fi)	1983-10-27
PL138718B1 (en)	1986-10-31
AU1394583A (en)	1983-11-03
IE830938L (en)	1983-10-26
US4783534A (en)	1988-11-08
DK159777B (da)	1990-12-03
ATE16185T1 (de)	1985-11-15

Publication	Publication Date	Title
ZA832883B (en)	1984-12-24	N-alkylnorscopines and their preparation
PT77344A (en)	1983-10-01	Process for the preparation of new diazabicyclo-3,3,1-nonanes
EP0110814A3 (en)	1985-07-24	Beta-carbolines, process for their preparation and pharmaceutical compositions containing them
IL76924A0 (en)	1986-04-29	Polypeptides,process for the preparation thereof and pharmaceutical compositions containing the same
IL57691A (en)	1983-10-31	Delta-4,9-gonadiene-21-ol-3,20-diones,process for preparing them and pharmaceutical compositions containing them
DE3362859D1 (en)	1986-05-15	Azolyl-phenoxy-tetrahydrofuran-2-ylidene methanes, process for their preparation and microbicides containing them
JPS567799A (en)	1981-01-27	Novel pseudotrisaccharide* its manufacture and use as medicine
ZA824118B (en)	1983-04-27	Saturated aminocyclitol derivatives, their preparation and medicaments containing these compounds
JPS5615298A (en)	1981-02-14	Sisomicin derivative
GR73033B (xx)	1984-01-26
IL74269A0 (en)	1985-05-31	2-alkoxyaminosulfonylbenzene-sulfonylureas,their production and their use as herbicides
ES8304571A1 (es)	1983-03-01	"procedimiento para la preparacion de nuevas 1,4,9,10-tetrahidro-pirazolo (4,3-e)pirido (3,2-b) (1,4)diazepin-10-onas".
ES467861A1 (es)	1978-10-16	Procedimiento de preparacion de espiro-oxazolidinas esteroi-des y sus esteroisomeros.
ZA839614B (en)	1984-08-29	4-hydroxy-benzhydrol derivatives,process for their preparation and pharmaceutical compositions containing them
AU2172688A (en)	1989-03-02	Preparation of dien-1-ols, 9-hydroxydodec-10-enyl 1-tert-butyl ether and use thereof as an intermediate for synthesizing, 8,10-dodecadienol
ES8401095A1 (es)	1983-12-01	Procedimiento para la preparacion de 11 -cloro-15-esteroides.
JPS5536485A (en)	1980-03-14	Nnaminoo3455trihydoxypiperidines*their manufacture and use as drug
DE3274979D1 (en)	1987-02-12	Alkylcycloalkyl-imidazolylmethyl ketones and process for preparing them