ZA774553B - 2-benzylpyrrolidines,process for their preparation,and medicaments containing them - Google Patents

2-benzylpyrrolidines,process for their preparation,and medicaments containing them

Info

Publication number
ZA774553B
ZA774553B ZA00774553A ZA774553A ZA774553B ZA 774553 B ZA774553 B ZA 774553B ZA 00774553 A ZA00774553 A ZA 00774553A ZA 774553 A ZA774553 A ZA 774553A ZA 774553 B ZA774553 B ZA 774553B
Authority
ZA
South Africa
Prior art keywords
benzylpyrrolidines
preparation
medicaments containing
medicaments
Prior art date
Application number
ZA00774553A
Other languages
English (en)
Inventor
H Schaefer
K Eistetter
H Menge
Original Assignee
Byk Gulden Lomberg Chem Fab
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Byk Gulden Lomberg Chem Fab filed Critical Byk Gulden Lomberg Chem Fab
Publication of ZA774553B publication Critical patent/ZA774553B/xx

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D207/00—Heterocyclic compounds containing five-membered rings not condensed with other rings, with one nitrogen atom as the only ring hetero atom
    • C07D207/02—Heterocyclic compounds containing five-membered rings not condensed with other rings, with one nitrogen atom as the only ring hetero atom with only hydrogen or carbon atoms directly attached to the ring nitrogen atom
    • C07D207/04—Heterocyclic compounds containing five-membered rings not condensed with other rings, with one nitrogen atom as the only ring hetero atom with only hydrogen or carbon atoms directly attached to the ring nitrogen atom having no double bonds between ring members or between ring members and non-ring members
    • C07D207/08—Heterocyclic compounds containing five-membered rings not condensed with other rings, with one nitrogen atom as the only ring hetero atom with only hydrogen or carbon atoms directly attached to the ring nitrogen atom having no double bonds between ring members or between ring members and non-ring members with hydrocarbon radicals, substituted by hetero atoms, attached to ring carbon atoms
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P25/00—Drugs for disorders of the nervous system
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P9/00—Drugs for disorders of the cardiovascular system
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D207/00—Heterocyclic compounds containing five-membered rings not condensed with other rings, with one nitrogen atom as the only ring hetero atom
    • C07D207/02—Heterocyclic compounds containing five-membered rings not condensed with other rings, with one nitrogen atom as the only ring hetero atom with only hydrogen or carbon atoms directly attached to the ring nitrogen atom
    • C07D207/04—Heterocyclic compounds containing five-membered rings not condensed with other rings, with one nitrogen atom as the only ring hetero atom with only hydrogen or carbon atoms directly attached to the ring nitrogen atom having no double bonds between ring members or between ring members and non-ring members
    • C07D207/10—Heterocyclic compounds containing five-membered rings not condensed with other rings, with one nitrogen atom as the only ring hetero atom with only hydrogen or carbon atoms directly attached to the ring nitrogen atom having no double bonds between ring members or between ring members and non-ring members with hetero atoms or with carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, e.g. ester or nitrile radicals, directly attached to ring carbon atoms
    • C07D207/14—Nitrogen atoms not forming part of a nitro radical
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D207/00—Heterocyclic compounds containing five-membered rings not condensed with other rings, with one nitrogen atom as the only ring hetero atom
    • C07D207/02—Heterocyclic compounds containing five-membered rings not condensed with other rings, with one nitrogen atom as the only ring hetero atom with only hydrogen or carbon atoms directly attached to the ring nitrogen atom
    • C07D207/18—Heterocyclic compounds containing five-membered rings not condensed with other rings, with one nitrogen atom as the only ring hetero atom with only hydrogen or carbon atoms directly attached to the ring nitrogen atom having one double bond between ring members or between a ring member and a non-ring member
    • C07D207/20—Heterocyclic compounds containing five-membered rings not condensed with other rings, with one nitrogen atom as the only ring hetero atom with only hydrogen or carbon atoms directly attached to the ring nitrogen atom having one double bond between ring members or between a ring member and a non-ring member with only hydrogen atoms, hydrocarbon or substituted hydrocarbon radicals, directly attached to ring carbon atoms
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D207/00—Heterocyclic compounds containing five-membered rings not condensed with other rings, with one nitrogen atom as the only ring hetero atom
    • C07D207/02—Heterocyclic compounds containing five-membered rings not condensed with other rings, with one nitrogen atom as the only ring hetero atom with only hydrogen or carbon atoms directly attached to the ring nitrogen atom
    • C07D207/18—Heterocyclic compounds containing five-membered rings not condensed with other rings, with one nitrogen atom as the only ring hetero atom with only hydrogen or carbon atoms directly attached to the ring nitrogen atom having one double bond between ring members or between a ring member and a non-ring member
    • C07D207/22—Heterocyclic compounds containing five-membered rings not condensed with other rings, with one nitrogen atom as the only ring hetero atom with only hydrogen or carbon atoms directly attached to the ring nitrogen atom having one double bond between ring members or between a ring member and a non-ring member with hetero atoms or with carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, e.g. ester or nitrile radicals, directly attached to ring carbon atoms
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D207/00—Heterocyclic compounds containing five-membered rings not condensed with other rings, with one nitrogen atom as the only ring hetero atom
    • C07D207/02—Heterocyclic compounds containing five-membered rings not condensed with other rings, with one nitrogen atom as the only ring hetero atom with only hydrogen or carbon atoms directly attached to the ring nitrogen atom
    • C07D207/18—Heterocyclic compounds containing five-membered rings not condensed with other rings, with one nitrogen atom as the only ring hetero atom with only hydrogen or carbon atoms directly attached to the ring nitrogen atom having one double bond between ring members or between a ring member and a non-ring member
    • C07D207/22—Heterocyclic compounds containing five-membered rings not condensed with other rings, with one nitrogen atom as the only ring hetero atom with only hydrogen or carbon atoms directly attached to the ring nitrogen atom having one double bond between ring members or between a ring member and a non-ring member with hetero atoms or with carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, e.g. ester or nitrile radicals, directly attached to ring carbon atoms
    • C07D207/24—Oxygen or sulfur atoms

Landscapes

  • Organic Chemistry (AREA)
  • Chemical & Material Sciences (AREA)
  • Health & Medical Sciences (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Medicinal Chemistry (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • General Chemical & Material Sciences (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Veterinary Medicine (AREA)
  • Engineering & Computer Science (AREA)
  • Public Health (AREA)
  • Animal Behavior & Ethology (AREA)
  • General Health & Medical Sciences (AREA)
  • Heart & Thoracic Surgery (AREA)
  • Biomedical Technology (AREA)
  • Neurology (AREA)
  • Neurosurgery (AREA)
  • Cardiology (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Pyrrole Compounds (AREA)
ZA00774553A 1976-07-28 1977-07-27 2-benzylpyrrolidines,process for their preparation,and medicaments containing them ZA774553B (en)

Applications Claiming Priority (1)

Application Number Priority Date Filing Date Title
LU75478A LU75478A1 (sv) 1976-07-28 1976-07-28

Publications (1)

Publication Number Publication Date
ZA774553B true ZA774553B (en) 1978-06-28

Family

ID=19728311

Family Applications (1)

Application Number Title Priority Date Filing Date
ZA00774553A ZA774553B (en) 1976-07-28 1977-07-27 2-benzylpyrrolidines,process for their preparation,and medicaments containing them

Country Status (23)

Country Link
US (1) US4279918A (sv)
JP (1) JPS5315367A (sv)
AT (1) AT373580B (sv)
AU (1) AU509015B2 (sv)
BE (1) BE857289A (sv)
CA (1) CA1104572A (sv)
CH (1) CH639368A5 (sv)
DE (2) DE2733817A1 (sv)
DK (1) DK339677A (sv)
ES (1) ES461077A1 (sv)
FR (1) FR2359823A1 (sv)
GB (1) GB1566761A (sv)
GR (1) GR61367B (sv)
IE (1) IE45320B1 (sv)
IL (1) IL52611A (sv)
IT (1) IT1085949B (sv)
LU (1) LU75478A1 (sv)
NL (1) NL7708306A (sv)
NZ (1) NZ184755A (sv)
PT (1) PT66858B (sv)
SE (1) SE429338B (sv)
YU (1) YU184277A (sv)
ZA (1) ZA774553B (sv)

Families Citing this family (12)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
AU518986B2 (en) * 1977-10-11 1981-10-29 Takeda Chemical Industries Ltd. Lactams
DE2952382A1 (de) * 1979-12-24 1981-07-16 Basf Ag, 6700 Ludwigshafen Phenylpropylammoniumsalze, verfahren zu ihrer herstellung und diese verbindungen enthaltende mittel
US4826869A (en) * 1988-02-19 1989-05-02 Syntex (U.S.A.) Inc. N-(lower alkyl)-2-(3'ureidobenzyl)pyrrolidines
IL94796A0 (en) * 1989-06-21 1991-04-15 Syntex Inc Bis(benzylpyrrolidine)derivatives,their preparation and pharmaceutical compositions containing them
US5100912A (en) * 1990-05-14 1992-03-31 Syntex (U.S.A.) Inc. Bis(benzylpyrrolidine) derivatives as dopamine agonists
US5135944A (en) * 1989-06-21 1992-08-04 Syntex (U.S.A.) Inc. Bis(benzylpyrrolidine) derivatives useful for treating congestive heart failure and acute renal failure
US5093355A (en) * 1989-10-30 1992-03-03 Syntex (U.S.A.) Inc. Benzylpyrrolidine derivatives as dopamine agonists
US5130432A (en) * 1990-12-21 1992-07-14 Syntex (U.S.A.) Inc. Process for preparing cyclic amines and intermediate products thereof
EP0562185A1 (en) * 1992-03-17 1993-09-29 Council of Scientific and Industrial Research 3-(Arylmethyl)-1-(3'-diethylaminopropyl) pyrrolidines and process of preparation thereof
US5248690A (en) * 1992-07-07 1993-09-28 R. J. Reynolds Tobacco Company Method for treatment of neurodegenerative diseases
US7208517B1 (en) * 1994-08-19 2007-04-24 Abbott Labortories Endothelin antagonists
CN104292143A (zh) * 2014-08-17 2015-01-21 湖南华腾制药有限公司 一种2-(4-溴苄基)吡咯烷的制备方法

Family Cites Families (5)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
DE1049380B (de) * 1959-01-29 Bergisch Gladbach Adolf Christian Josef Opfermann Verfahren zur Herstellung von a-substituierten Pyrrolidinen
FR86099E (fr) 1963-08-20 1965-12-03 Pechiney Saint Gobain Dérivés de la delta1-pyrroline
DE1470387A1 (de) 1963-12-20 1969-05-29 Union Carbide Corp Verfahren zur Herstellung von substituierten Pyrrolderivaten
GB1168797A (en) 1965-12-09 1969-10-29 Nat Res Dev Cyclopropane Carboxylic Acid Derivatives and their use as Insecticides
US3635982A (en) * 1969-04-08 1972-01-18 American Home Prod Amino-substituted-quinoxalinyloxazolidines and -oxazines

Also Published As

Publication number Publication date
NL7708306A (nl) 1978-01-31
FR2359823A1 (fr) 1978-02-24
IL52611A0 (en) 1977-10-31
SE7708621L (sv) 1978-01-29
US4279918A (en) 1981-07-21
ES461077A1 (es) 1978-12-01
CH639368A5 (de) 1983-11-15
IT1085949B (it) 1985-05-28
JPS5315367A (en) 1978-02-13
DE2733817A1 (de) 1978-02-02
LU75478A1 (sv) 1978-02-08
GB1566761A (en) 1980-05-08
CA1104572A (en) 1981-07-07
IE45320B1 (en) 1982-07-28
IL52611A (en) 1981-10-30
ATA548177A (de) 1983-06-15
SE429338B (sv) 1983-08-29
PT66858A (de) 1977-08-01
AU2736577A (en) 1979-02-01
AU509015B2 (en) 1980-04-17
GR61367B (en) 1978-10-30
YU184277A (en) 1983-02-28
DK339677A (da) 1978-01-29
IE45320L (en) 1978-01-28
NZ184755A (en) 1979-12-11
PT66858B (de) 1979-03-13
FR2359823B1 (sv) 1980-11-21
DE2733753A1 (de) 1978-02-02
AT373580B (de) 1984-02-10
BE857289A (fr) 1978-01-30

Similar Documents

Publication Publication Date Title
DE2960222D1 (en) Phenoxyalkylcarboxylic-acid derivatives, process for their preparation and medicaments containing them
DE2861809D1 (en) Corticoids-17-alkylcarbonates, process for their preparation and preparations containing them
IL53063A (en) Phenoxy-amino-propanols,processes for their preparation and pharmaceutical compositions comprising them
DE2963321D1 (en) 1-benzoyl-2-pyrrolidinone derivative, processes for its preparation and medicaments containing it
DE2860637D1 (en) Dihydrouracils, process for their preparation and pharmaceuticals containing them
HK23782A (en) Amino-sugar derivatives,process for their preparation and their use as medicaments
ZA77372B (en) 1,2-benzisothiazolin-3-ones,processes for their preparation and their use as medicaments
GB1554495A (en) 2-aminoalkylideneamino-1,4-dihydropyridines processes for their preparation and their use as medicaments
IL52611A (en) 2-benzylpyrrolidines,process for their preparation and medicaments containing them
IL51857A (en) Bid-quaternary pyridinium-2-aldoxime salts,process for their preparation and pharmaceutical compositions containing them
DE2961983D1 (en) Pyrrolidine-2-methanol derivatives, process for their preparation and medicaments containing them
DE2960024D1 (en) Substituted diphenylmethyl-imidazoles, their preparation and medicaments containing them
IL61371A (en) Medicaments containing phenyloxoalkanoic acids,some new such acids and processes for their preparation
IL51877A0 (en) Omega-nor-aromatic-13,14-dehydro-prostaglandins and process for their preparation
MY8600270A (en) Phenylaminothiophenacetic acids, processes for their preparation and medicaments containing them
DE2860991D1 (en) Substituted pyrrolidines, process for their preparation and medicaments containing them
DE2964198D1 (en) Indanamine derivatives, process for their preparation and medicaments containing them
DE2860928D1 (en) 2,4-diamino-5-benzyl-pyrimidines, process for their preparation and medicines containing them
IL52148A (en) Substituted 1-phenoxy-2-hydroxy-3-aminopropanes,process for preparing same and pharmaceutical compositions containing them
GB1538705A (en) 1,4-dihydropyridine-sugar derivatives process for their preparation and their use as medicaments
DE2860614D1 (en) N-benzylpyrimidinyl-amidines, process for their preparation and medicines containing them
HK96984A (en) Glucofuranosyl-nitrosourea derivatives,processes for their preparation and medicaments containing them
IL52207A (en) Substituted 2-vinyl-chromones, process for their preparation and pharmaceutical compositions containing them
DE3065906D1 (en) Pyridine derivatives, process for their preparation and medicaments containing them
DE2960205D1 (en) 4-hydroxy-2-benzimidazolin-thion derivatives, process for their preparation and medicaments containing them