WO2009146153A3 - Manufacture, transport and delivery of material containing highly polarized nuclei - Google Patents

Manufacture, transport and delivery of material containing highly polarized nuclei Download PDF

Info

Publication number
WO2009146153A3
WO2009146153A3 PCT/US2009/039696 US2009039696W WO2009146153A3 WO 2009146153 A3 WO2009146153 A3 WO 2009146153A3 US 2009039696 W US2009039696 W US 2009039696W WO 2009146153 A3 WO2009146153 A3 WO 2009146153A3
Authority
WO
WIPO (PCT)
Prior art keywords
delivery
transport
manufacture
material containing
highly polarized
Prior art date
Application number
PCT/US2009/039696
Other languages
French (fr)
Other versions
WO2009146153A2 (en
Inventor
Neal Kalechofsky
Avrum Belzer
Original Assignee
Millikelvin Technologies Llc
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Priority claimed from US12/193,536 external-priority patent/US20090016964A1/en
Application filed by Millikelvin Technologies Llc filed Critical Millikelvin Technologies Llc
Priority to AU2009251528A priority Critical patent/AU2009251528B2/en
Priority to EP09755515.5A priority patent/EP2459234A4/en
Priority to CA2720333A priority patent/CA2720333C/en
Publication of WO2009146153A2 publication Critical patent/WO2009146153A2/en
Publication of WO2009146153A3 publication Critical patent/WO2009146153A3/en
Priority to US12/879,634 priority patent/US8703102B2/en
Priority to US14/190,945 priority patent/US20140218029A1/en
Priority to US14/257,787 priority patent/US20140223923A1/en
Priority to US15/230,739 priority patent/US20170082711A1/en
Priority to US15/612,456 priority patent/US20170269180A1/en

Links

Classifications

    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K49/00—Preparations for testing in vivo
    • A61K49/06—Nuclear magnetic resonance [NMR] contrast preparations; Magnetic resonance imaging [MRI] contrast preparations
    • A61K49/08—Nuclear magnetic resonance [NMR] contrast preparations; Magnetic resonance imaging [MRI] contrast preparations characterised by the carrier
    • A61K49/10—Organic compounds
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P43/00—Drugs for specific purposes, not provided for in groups A61P1/00-A61P41/00
    • G—PHYSICS
    • G01—MEASURING; TESTING
    • G01R—MEASURING ELECTRIC VARIABLES; MEASURING MAGNETIC VARIABLES
    • G01R33/00—Arrangements or instruments for measuring magnetic variables
    • G01R33/20—Arrangements or instruments for measuring magnetic variables involving magnetic resonance
    • G01R33/28—Details of apparatus provided for in groups G01R33/44 - G01R33/64
    • G01R33/282—Means specially adapted for hyperpolarisation or for hyperpolarised contrast agents, e.g. for the generation of hyperpolarised gases using optical pumping cells, for storing hyperpolarised contrast agents or for the determination of the polarisation of a hyperpolarised contrast agent
    • G—PHYSICS
    • G01—MEASURING; TESTING
    • G01R—MEASURING ELECTRIC VARIABLES; MEASURING MAGNETIC VARIABLES
    • G01R33/00—Arrangements or instruments for measuring magnetic variables
    • G01R33/20—Arrangements or instruments for measuring magnetic variables involving magnetic resonance
    • G01R33/44—Arrangements or instruments for measuring magnetic variables involving magnetic resonance using nuclear magnetic resonance [NMR]
    • G01R33/48—NMR imaging systems
    • G01R33/54—Signal processing systems, e.g. using pulse sequences ; Generation or control of pulse sequences; Operator console
    • G01R33/56—Image enhancement or correction, e.g. subtraction or averaging techniques, e.g. improvement of signal-to-noise ratio and resolution
    • G01R33/5601—Image enhancement or correction, e.g. subtraction or averaging techniques, e.g. improvement of signal-to-noise ratio and resolution involving use of a contrast agent for contrast manipulation, e.g. a paramagnetic, super-paramagnetic, ferromagnetic or hyperpolarised contrast agent

Landscapes

  • Health & Medical Sciences (AREA)
  • Physics & Mathematics (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • General Health & Medical Sciences (AREA)
  • Public Health (AREA)
  • Engineering & Computer Science (AREA)
  • Chemical & Material Sciences (AREA)
  • Radiology & Medical Imaging (AREA)
  • Medicinal Chemistry (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Animal Behavior & Ethology (AREA)
  • General Physics & Mathematics (AREA)
  • Condensed Matter Physics & Semiconductors (AREA)
  • Veterinary Medicine (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Epidemiology (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • General Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Signal Processing (AREA)
  • High Energy & Nuclear Physics (AREA)
  • Medicines Containing Antibodies Or Antigens For Use As Internal Diagnostic Agents (AREA)
  • Magnetic Resonance Imaging Apparatus (AREA)
  • Preparation Of Compounds By Using Micro-Organisms (AREA)
  • Saccharide Compounds (AREA)

Abstract

The present disclosure provides various methods and systems for manufacture, transport and delivery of material including highly polarized nuclei that is in a hyperpolarized state.
PCT/US2009/039696 2006-02-21 2009-04-06 Manufacture, transport and delivery of material containing highly polarized nuclei WO2009146153A2 (en)

Priority Applications (8)

Application Number Priority Date Filing Date Title
AU2009251528A AU2009251528B2 (en) 2008-04-04 2009-04-06 Manufacture, transport and delivery of material containing highly polarized nuclei
EP09755515.5A EP2459234A4 (en) 2008-04-04 2009-04-06 Manufacture, transport and delivery of material containing highly polarized nuclei
CA2720333A CA2720333C (en) 2008-04-04 2009-04-06 Manufacture, transport and delivery of material containing highly polarized nuclei
US12/879,634 US8703102B2 (en) 2008-04-04 2010-09-10 Systems and methods for producing hyperpolarized materials and mixtures thereof
US14/190,945 US20140218029A1 (en) 2006-02-21 2014-02-26 Techniques, systems and machine readable programs for magnetic resonance
US14/257,787 US20140223923A1 (en) 2008-04-04 2014-04-21 Systems and methods for producing hyperpolarized materials and mixtures thereof
US15/230,739 US20170082711A1 (en) 2006-02-21 2016-08-08 Techniques, systems and machine readable programs for magnetic resonance
US15/612,456 US20170269180A1 (en) 2006-02-21 2017-06-02 Systems and related methods for rapidly moving materials into and out of a cryogenic environment

Applications Claiming Priority (6)

Application Number Priority Date Filing Date Title
US4239808P 2008-04-04 2008-04-04
US61/042,398 2008-04-04
US12/193,536 US20090016964A1 (en) 2006-02-21 2008-08-18 Hyperpolarization methods, systems and compositions
US12/193,536 2008-08-18
US11105008P 2008-11-04 2008-11-04
US61/111,050 2008-11-04

Related Child Applications (2)

Application Number Title Priority Date Filing Date
PCT/US2010/047310 Continuation-In-Part WO2011026103A2 (en) 2006-02-21 2010-08-31 Systems and methods for producing hyperpolarized materials and mixtures thereof
US12/879,634 Continuation-In-Part US8703102B2 (en) 2006-02-21 2010-09-10 Systems and methods for producing hyperpolarized materials and mixtures thereof

Publications (2)

Publication Number Publication Date
WO2009146153A2 WO2009146153A2 (en) 2009-12-03
WO2009146153A3 true WO2009146153A3 (en) 2010-01-21

Family

ID=41377877

Family Applications (1)

Application Number Title Priority Date Filing Date
PCT/US2009/039696 WO2009146153A2 (en) 2006-02-21 2009-04-06 Manufacture, transport and delivery of material containing highly polarized nuclei

Country Status (4)

Country Link
EP (1) EP2459234A4 (en)
AU (1) AU2009251528B2 (en)
CA (1) CA2720333C (en)
WO (1) WO2009146153A2 (en)

Families Citing this family (2)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
CN101511264A (en) 2006-02-21 2009-08-19 米利开尔文科技有限公司 Hyperpolarization methods, systems and compositions
US8703102B2 (en) 2008-04-04 2014-04-22 Millikelvin Technologies Llc Systems and methods for producing hyperpolarized materials and mixtures thereof

Citations (4)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US20050200356A1 (en) * 2004-03-11 2005-09-15 Juergen Hennig Method for measuring the nuclear magnetic resonance (NMR) of substances having hyperpolarized nuclei using continuously refocused multiecho spectroscopic imaging
US20070156046A1 (en) * 2004-01-19 2007-07-05 Hasing Friedrich W Method of enriching hyperpolarized atom nuclei and an apparatus for implementing the method
WO2007136439A2 (en) * 2006-02-21 2007-11-29 Avrum Belzer Hyperpolarization methods, systems and compositions
US20080000471A1 (en) * 2003-04-22 2008-01-03 Kenneth Bolam Mri/nmr-compatible, tidal volume control and measurement systems, methods, and devices for respiratory and hyperpolarized gas delivery

Family Cites Families (2)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
GB0001727D0 (en) * 2000-01-25 2000-03-15 Oxford Instr Uk Ltd Hyperpolarization of a noble gas
GB0514303D0 (en) * 2005-07-12 2005-08-17 Oxford Instr Molecular Biotool Magnet assembly

Patent Citations (4)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US20080000471A1 (en) * 2003-04-22 2008-01-03 Kenneth Bolam Mri/nmr-compatible, tidal volume control and measurement systems, methods, and devices for respiratory and hyperpolarized gas delivery
US20070156046A1 (en) * 2004-01-19 2007-07-05 Hasing Friedrich W Method of enriching hyperpolarized atom nuclei and an apparatus for implementing the method
US20050200356A1 (en) * 2004-03-11 2005-09-15 Juergen Hennig Method for measuring the nuclear magnetic resonance (NMR) of substances having hyperpolarized nuclei using continuously refocused multiecho spectroscopic imaging
WO2007136439A2 (en) * 2006-02-21 2007-11-29 Avrum Belzer Hyperpolarization methods, systems and compositions

Non-Patent Citations (1)

* Cited by examiner, † Cited by third party
Title
See also references of EP2459234A4 *

Also Published As

Publication number Publication date
EP2459234A4 (en) 2013-07-31
WO2009146153A2 (en) 2009-12-03
EP2459234A2 (en) 2012-06-06
AU2009251528B2 (en) 2014-09-18
CA2720333A1 (en) 2009-12-03
AU2009251528A1 (en) 2009-12-03
CA2720333C (en) 2017-01-24

Similar Documents

Publication Publication Date Title
EP2918481B8 (en) Intermodal tank transport system, components, and methods
WO2012047857A3 (en) Coupling of rational agents to quantum processes
TW200745261A (en) Aqueous dispersions based on nitrocellulose-polyurethane particles
EP2285709A4 (en) Aerosol acctuation systems and methods for making the same
EP2021022A4 (en) Apparatus, methods and systems for toxin delivery to the nasal cavity
EP1998751A4 (en) Devices, systems and methods for medicament delivery
EP2005625A4 (en) Methods, systems, and apparatus for multi-purpose metering
SG10201510159XA (en) Generally cylindrically-shaped liner for use in pressure dispense systems and methods of manufacturing the same
WO2007143086A3 (en) Delivery method
PH12014502007A1 (en) Process for the preparation of 5-substituted-8-alkoxy[1,2,4]triazolo[1,5-c]pyrimidin-2-amides
TN2013000305A1 (en) Spool for receiving winding material and spool part system.
WO2011118960A3 (en) Method for preparing nano-particles
AU2007270125A8 (en) Preservation and controlled delivery/release of spermatozoa
GB201401103D0 (en) Valve for use in chemical injectors and the like
IL223077A0 (en) Novel as160-like protein, test systems, methods and uses involving it for the identification of diabetes type 2 therapeutics
UA101729C2 (en) Dispenser for smoking articles and cartridge for said dispenser
WO2011026103A3 (en) Systems and methods for producing hyperpolarized materials and mixtures thereof
WO2009152167A3 (en) Delivery of therapeutics
WO2009149058A3 (en) Modified release niacin formulations
MX2010002195A (en) Nozzle for dnp polarizer.
EP2012719A4 (en) Devices, systems and methods using magnetic force systems in the tongue
WO2012155076A3 (en) Imaging contrast agents and uses thereof
WO2009146153A3 (en) Manufacture, transport and delivery of material containing highly polarized nuclei
WO2009044153A3 (en) Inhibitors and uses
WO2012019204A3 (en) Therapeutic agent for intranasal administration and method of making and using same

Legal Events

Date Code Title Description
121 Ep: the epo has been informed by wipo that ep was designated in this application

Ref document number: 09755515

Country of ref document: EP

Kind code of ref document: A2

WWE Wipo information: entry into national phase

Ref document number: 2009251528

Country of ref document: AU

WWE Wipo information: entry into national phase

Ref document number: 6605/DELNP/2010

Country of ref document: IN

ENP Entry into the national phase

Ref document number: 2009251528

Country of ref document: AU

Date of ref document: 20090406

Kind code of ref document: A

WWE Wipo information: entry into national phase

Ref document number: 2720333

Country of ref document: CA

NENP Non-entry into the national phase

Ref country code: DE

122 Ep: pct application non-entry in european phase

Ref document number: 09755515

Country of ref document: EP

Kind code of ref document: A2

WWE Wipo information: entry into national phase

Ref document number: 2009755515

Country of ref document: EP