WO2006002437A3 - Treatment of conditions involving demyelination - Google Patents

Treatment of conditions involving demyelination Download PDF

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Publication number
WO2006002437A3
WO2006002437A3 PCT/US2005/022881 US2005022881W WO2006002437A3 WO 2006002437 A3 WO2006002437 A3 WO 2006002437A3 US 2005022881 W US2005022881 W US 2005022881W WO 2006002437 A3 WO2006002437 A3 WO 2006002437A3
Authority
WO
WIPO (PCT)
Prior art keywords
treatment
conditions involving
involving demyelination
demyelination
disorsers
Prior art date
Application number
PCT/US2005/022881
Other languages
French (fr)
Other versions
WO2006002437A2 (en
Inventor
Sha Mi
R Blake Pepinsky
John Mccoy
Original Assignee
Biogen Idec Inc
Sha Mi
R Blake Pepinsky
John Mccoy
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Priority to EP05764255A priority Critical patent/EP1776136B1/en
Priority to CA002572193A priority patent/CA2572193A1/en
Priority to DK05764255.5T priority patent/DK1776136T3/en
Priority to AU2005258335A priority patent/AU2005258335B2/en
Priority to PL05764255T priority patent/PL1776136T3/en
Priority to ES05764255T priority patent/ES2395094T3/en
Priority to BRPI0512500-6A priority patent/BRPI0512500A/en
Priority to KR1020077001531A priority patent/KR101239542B1/en
Application filed by Biogen Idec Inc, Sha Mi, R Blake Pepinsky, John Mccoy filed Critical Biogen Idec Inc
Priority to CN200580020998.0A priority patent/CN1972707B/en
Priority to JP2007518365A priority patent/JP4960865B2/en
Priority to RS20120532A priority patent/RS52593B/en
Priority to SI200531642T priority patent/SI1776136T1/en
Publication of WO2006002437A2 publication Critical patent/WO2006002437A2/en
Priority to IL180077A priority patent/IL180077A/en
Publication of WO2006002437A3 publication Critical patent/WO2006002437A3/en
Priority to HK07108850.5A priority patent/HK1103978A1/en
Priority to HRP20121061TT priority patent/HRP20121061T1/en

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    • G—PHYSICS
    • G01—MEASURING; TESTING
    • G01N—INVESTIGATING OR ANALYSING MATERIALS BY DETERMINING THEIR CHEMICAL OR PHYSICAL PROPERTIES
    • G01N33/00—Investigating or analysing materials by specific methods not covered by groups G01N1/00 - G01N31/00
    • G01N33/48—Biological material, e.g. blood, urine; Haemocytometers
    • G01N33/50—Chemical analysis of biological material, e.g. blood, urine; Testing involving biospecific ligand binding methods; Immunological testing
    • G01N33/68—Chemical analysis of biological material, e.g. blood, urine; Testing involving biospecific ligand binding methods; Immunological testing involving proteins, peptides or amino acids
    • G01N33/6893—Chemical analysis of biological material, e.g. blood, urine; Testing involving biospecific ligand binding methods; Immunological testing involving proteins, peptides or amino acids related to diseases not provided for elsewhere
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A61K31/70—Carbohydrates; Sugars; Derivatives thereof
    • A61K31/7088—Compounds having three or more nucleosides or nucleotides
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K38/00—Medicinal preparations containing peptides
    • A61K38/16—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof
    • A61K38/17—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from animals; from humans
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K38/00—Medicinal preparations containing peptides
    • A61K38/16—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof
    • A61K38/17—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from animals; from humans
    • A61K38/1703—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from animals; from humans from vertebrates
    • A61K38/1709—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from animals; from humans from vertebrates from mammals
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K39/00—Medicinal preparations containing antigens or antibodies
    • A61K39/395—Antibodies; Immunoglobulins; Immune serum, e.g. antilymphocytic serum
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P25/00—Drugs for disorders of the nervous system
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P25/00—Drugs for disorders of the nervous system
    • A61P25/14—Drugs for disorders of the nervous system for treating abnormal movements, e.g. chorea, dyskinesia
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P25/00—Drugs for disorders of the nervous system
    • A61P25/14—Drugs for disorders of the nervous system for treating abnormal movements, e.g. chorea, dyskinesia
    • A61P25/16—Anti-Parkinson drugs
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P25/00—Drugs for disorders of the nervous system
    • A61P25/28—Drugs for disorders of the nervous system for treating neurodegenerative disorders of the central nervous system, e.g. nootropic agents, cognition enhancers, drugs for treating Alzheimer's disease or other forms of dementia
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P27/00—Drugs for disorders of the senses
    • A61P27/02—Ophthalmic agents
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P3/00—Drugs for disorders of the metabolism
    • A61P3/02—Nutrients, e.g. vitamins, minerals
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P37/00—Drugs for immunological or allergic disorders
    • A61P37/02—Immunomodulators
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P9/00—Drugs for disorders of the cardiovascular system
    • A61P9/10—Drugs for disorders of the cardiovascular system for treating ischaemic or atherosclerotic diseases, e.g. antianginal drugs, coronary vasodilators, drugs for myocardial infarction, retinopathy, cerebrovascula insufficiency, renal arteriosclerosis
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K2319/00—Fusion polypeptide
    • C07K2319/30—Non-immunoglobulin-derived peptide or protein having an immunoglobulin constant or Fc region, or a fragment thereof, attached thereto

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  • Health & Medical Sciences (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Engineering & Computer Science (AREA)
  • Chemical & Material Sciences (AREA)
  • Medicinal Chemistry (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • General Health & Medical Sciences (AREA)
  • Public Health (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Veterinary Medicine (AREA)
  • Animal Behavior & Ethology (AREA)
  • Immunology (AREA)
  • Biomedical Technology (AREA)
  • General Chemical & Material Sciences (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Organic Chemistry (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • Epidemiology (AREA)
  • Proteomics, Peptides & Aminoacids (AREA)
  • Neurosurgery (AREA)
  • Neurology (AREA)
  • Zoology (AREA)
  • Gastroenterology & Hepatology (AREA)
  • Urology & Nephrology (AREA)
  • Hematology (AREA)
  • Molecular Biology (AREA)
  • Microbiology (AREA)
  • Marine Sciences & Fisheries (AREA)
  • Psychology (AREA)
  • Biochemistry (AREA)
  • Physics & Mathematics (AREA)
  • Pathology (AREA)
  • Biotechnology (AREA)
  • Cell Biology (AREA)
  • General Physics & Mathematics (AREA)
  • Analytical Chemistry (AREA)
  • Food Science & Technology (AREA)
  • Nutrition Science (AREA)
  • Mycology (AREA)
  • Diabetes (AREA)

Abstract

The invention provides methods of treating diseases, disorsers or injuries involving demyelination and dysmyelination, including multiple sclerosis, by the administration of an Sp35 antagonist.
PCT/US2005/022881 2004-06-24 2005-06-24 Treatment of conditions involving demyelination WO2006002437A2 (en)

Priority Applications (15)

Application Number Priority Date Filing Date Title
CN200580020998.0A CN1972707B (en) 2004-06-24 2005-06-24 Treatment of conditions involving demyelination
CA002572193A CA2572193A1 (en) 2004-06-24 2005-06-24 Treatment of conditions involving oligodendrocytes with sp35 based agents
JP2007518365A JP4960865B2 (en) 2004-06-24 2005-06-24 Treatment of conditions related to demyelination
PL05764255T PL1776136T3 (en) 2004-06-24 2005-06-24 Treatment of conditions involving demyelination
ES05764255T ES2395094T3 (en) 2004-06-24 2005-06-24 Treatment of conditions that involve demyelination
BRPI0512500-6A BRPI0512500A (en) 2004-06-24 2005-06-24 treatment or conditions involving demyelination
KR1020077001531A KR101239542B1 (en) 2004-06-24 2005-06-24 Treatment of conditions involving demyelination
EP05764255A EP1776136B1 (en) 2004-06-24 2005-06-24 Treatment of conditions involving demyelination
DK05764255.5T DK1776136T3 (en) 2004-06-24 2005-06-24 Treatment of conditions involving demyelination
AU2005258335A AU2005258335B2 (en) 2004-06-24 2005-06-24 Treatment of conditions involving demyelination
RS20120532A RS52593B (en) 2004-06-24 2005-06-24 Treatment of conditions involving demyelination
SI200531642T SI1776136T1 (en) 2004-06-24 2005-06-24 Treatment of conditions involving demyelination
IL180077A IL180077A (en) 2004-06-24 2006-12-14 In vitro methods, uses and compositions for promoting differentiation or survival of oligodendrocytes using lingo-1 antagonist antibodies
HK07108850.5A HK1103978A1 (en) 2004-06-24 2007-08-14 Treatment of conditions involving demyelination
HRP20121061TT HRP20121061T1 (en) 2004-06-24 2012-12-21 Treatment of conditions involving demyelination

Applications Claiming Priority (8)

Application Number Priority Date Filing Date Title
US58296604P 2004-06-24 2004-06-24
US60/582,966 2004-06-24
US61729704P 2004-10-07 2004-10-07
US60/617,297 2004-10-07
US62843504P 2004-11-15 2004-11-15
US60/628,435 2004-11-15
US68047505P 2005-05-13 2005-05-13
US60/680,475 2005-05-13

Publications (2)

Publication Number Publication Date
WO2006002437A2 WO2006002437A2 (en) 2006-01-05
WO2006002437A3 true WO2006002437A3 (en) 2006-12-28

Family

ID=35782388

Family Applications (1)

Application Number Title Priority Date Filing Date
PCT/US2005/022881 WO2006002437A2 (en) 2004-06-24 2005-06-24 Treatment of conditions involving demyelination

Country Status (16)

Country Link
US (2) US8486893B2 (en)
EP (2) EP1776136B1 (en)
JP (2) JP4960865B2 (en)
KR (1) KR101239542B1 (en)
AU (1) AU2005258335B2 (en)
BR (1) BRPI0512500A (en)
CA (1) CA2572193A1 (en)
DK (1) DK1776136T3 (en)
ES (1) ES2395094T3 (en)
HK (1) HK1103978A1 (en)
HR (1) HRP20121061T1 (en)
IL (1) IL180077A (en)
PL (1) PL1776136T3 (en)
PT (1) PT1776136E (en)
RS (1) RS52593B (en)
WO (1) WO2006002437A2 (en)

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EP2248899B8 (en) 2003-03-19 2015-07-15 Biogen MA Inc. NOGO receptor binding protein
BRPI0512500A (en) 2004-06-24 2008-03-11 Biogen Idec Inc treatment or conditions involving demyelination
CA2902070A1 (en) 2005-07-08 2007-01-18 Biogen Idec Ma Inc. Sp35 antibodies and uses thereof
MX2008005764A (en) 2005-11-04 2008-11-18 Biogen Idec Inc Methods for promoting neurite outgrowth and survival of dopaminergic neurons.
WO2007064882A2 (en) * 2005-12-02 2007-06-07 Biogen Idec Ma Inc. Treatment of conditions involving demyelination
US20110123535A1 (en) * 2006-05-15 2011-05-26 Biogen Idec Ma Inc. Use of Nogo Receptor-1 (NGR1) for Promoting Oligodendrocyte Survival
JP2009544703A (en) 2006-07-24 2009-12-17 バイオジェン・アイデック・エムエイ・インコーポレイテッド Method for promoting myelination, neuronal survival and oligodendrocyte differentiation by administration of an Sp35 or TrkA antagonist
AU2007321817A1 (en) * 2006-11-17 2008-05-22 Novartis Ag Lingo binding molecules and pharmaceutical use thereof
PL2068887T3 (en) * 2007-01-09 2014-09-30 Biogen Ma Inc Sp35 antibodies and uses thereof
US8128926B2 (en) * 2007-01-09 2012-03-06 Biogen Idec Ma Inc. Sp35 antibodies and uses thereof
CA2701189C (en) * 2007-10-11 2017-05-16 Biogen Idec Ma Inc. Methods for treating pressure induced optic neuropathy, preventing neuronal degeneration and promoting neuronal cell survival via administration of lingo-1 antagonists and trkb agonists
US20110123553A1 (en) * 2007-11-08 2011-05-26 Biogen Idec Ma Inc. Use of LINGO-4 Antagonists in the Treatment of Conditions Involving Demyelination
AU2009269099B2 (en) * 2008-07-09 2016-03-10 Biogen Ma Inc. Compositions comprising antibodies to LINGO or fragments thereof
EA030716B1 (en) 2012-05-14 2018-09-28 Байоджен Ма Инк. Lingo-2 antagonists for treatment of conditions involving motor neurons
MX2015004436A (en) 2012-10-09 2015-06-24 Biogen Idec Inc Combination therapies and uses for treatment of demyelinating disorders.
MX2017009038A (en) 2015-01-08 2017-10-25 Biogen Ma Inc Lingo-1 antagonists and uses for treatment of demyelinating disorders.
US10118904B2 (en) 2015-06-05 2018-11-06 Vertex Pharmaceuticals Incorporated Triazoles for the treatment of Demyelinating Diseases
KR20190039134A (en) 2016-07-13 2019-04-10 바이오젠 엠에이 인코포레이티드 Use of LINGO-1 antagonists for the treatment regimens and for the treatment of dehydration diseases
WO2018106643A1 (en) 2016-12-06 2018-06-14 Vertex Pharmaceuticals Incorporated Heterocyclic azoles for the treatment of demyelinating diseases
WO2018106646A1 (en) 2016-12-06 2018-06-14 Vertex Pharmaceuticals Incorporated Aminotriazoles for the treatment of demyelinating diseases
WO2018106641A1 (en) 2016-12-06 2018-06-14 Vertex Pharmaceuticals Incorporated Pyrazoles for the treatment of demyelinating diseases
TW202103732A (en) 2019-03-11 2021-02-01 美商百健Ｍａ公司 Pharmaceutical compositions containing anti-lingo-1 antibodies

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